GIPR Protein (Fc Tag)

N° du produit ABIN7491455

Détail du produit

Antigène: GIPR (Gastric Inhibitory Polypeptide Receptor (GIPR))

Type de proteíne: Recombinant

Origine: Humain

Source: HEK-293 Cells

Purification/Conjugué: Cette GIPR protéine est marqué à la Fc Tag.

Fonction: Recombinant Human GIPR Protein with C-terminal human Fc tag

Specificité: GIPR (Arg22-Gln138) hFc (Glu99-Ala330)

Attributs du produit: Extracellular Domain Protein

Pureté: The purity of the protein is greater than 95 % as determined by SDS-PAGE and Coomassie blue staining.

Information d'application

Restrictions: For Research Use only

Stockage

Format: Lyophilized

Buffer: sterile PBS, pH 7.4. Normally 5 % - 8 % trehalose is added as protectants before lyophilization.

Stock: -20 °C,-80 °C

Stockage commentaire: Store at -20°C to -80°C for 12 months in lyophilized form. After reconstitution, if not intended for use within a month, aliquot and store at -80°C (Avoid repeated freezing and thawing). Lyophilized proteins are shipped at ambient temperature.

Date de péremption: 12 months

Détail du antigène

Antigène: GIPR (Gastric Inhibitory Polypeptide Receptor (GIPR))

Autre désignation: GIPR (GIPR Produits)

Synonymes: GIPR Protein, PGQTL2 Protein, GIP-R Protein, Gm1081 Protein, Gm160 Protein, Gippr Protein, RATGIPPR Protein, gastric inhibitory polypeptide receptor Protein, glucagon receptor Protein, GIPR Protein, LOC100303705 Protein, Gipr Protein

Sujet: PGQTL2
Description: This gene encodes a G-protein coupled receptor for gastric inhibitory polypeptide (GIP), which was originally identified as an activity in gut extracts that inhibited gastric acid secretion and gastrin release, but subsequently was demonstrated to stimulate insulin release in the presence of elevated glucose. Mice lacking this gene exhibit higher blood glucose levels with impaired initial insulin response after oral glucose load. Defect in this gene thus may contribute to the pathogenesis of diabetes. [provided by RefSeq, Oct 2011]

Poids moléculaire: predicted molecular mass of 39.6 kDa after removal of the signal peptide. The apparent molecular mass of GIPR-hFc is 35-55 kDa due to glycosylation.

UniProt: P48546

Pathways: Positive Regulation of Peptide Hormone Secretion, cAMP Metabolic Process, Regulation of G-Protein Coupled Receptor Protein Signaling