Hepcidin Protein (Fc Tag)

N° du produit ABIN7491463

Détail du produit

Antigène: Hepcidin (HAMP) (Hepcidin Antimicrobial Peptide (HAMP))

Type de proteíne: Recombinant

Origine: Humain

Source: HEK-293 Cells

Purification/Conjugué: Cette Hepcidin protéine est marqué à la Fc Tag.

Fonction: Recombinant Human HAMP (65-84) Protein with C-terminal human Fc tag

Specificité: HAMP (Ile65-Thr84) hFc (Glu99-Ala330)

Attributs du produit: Extracellular Domain Protein

Pureté: The purity of the protein is greater than 95 % as determined by SDS-PAGE and Coomassie blue staining.

Information d'application

Restrictions: For Research Use only

Stockage

Format: Lyophilized

Buffer: sterile PBS, pH 7.4. Normally 5 % - 8 % trehalose is added as protectants before lyophilization.

Stock: -20 °C,-80 °C

Stockage commentaire: Store at -20°C to -80°C for 12 months in lyophilized form. After reconstitution, if not intended for use within a month, aliquot and store at -80°C (Avoid repeated freezing and thawing). Lyophilized proteins are shipped at ambient temperature.

Date de péremption: 12 months

Détail du antigène

Antigène: Hepcidin (HAMP) (Hepcidin Antimicrobial Peptide (HAMP))

Autre désignation: HAMP (HAMP Produits)

Synonymes: HEPC Protein, HFE2B Protein, LEAP1 Protein, PLTR Protein, Hepcidin Protein, Hamp1 Protein, Hepc Protein, Hepc1 Protein, HAMP Protein, hepcidin Protein, hamp1 Protein, hep1 Protein, hepcidin antimicrobial peptide Protein, hepcidin-like Protein, hepcidin-1 Protein, Ham percentage Protein, HAMP Protein, Hamp Protein, hamp Protein, LOC100135935 Protein, LOC106584587 Protein

Sujet: HEPC, HFE2B, LEAP1, PLTRThe product encoded by this gene is involved in the maintenance of iron homeostasis, and it is necessary for the regulation of iron storage in macrophages, and for intestinal iron absorption. The preproprotein is post-translationally cleaved into mature peptides of 20, 22 and 25 amino acids, and these active peptides are rich in cysteines, which form intramolecular bonds that stabilize their beta-sheet structures. These peptides exhibit antimicrobial activity against bacteria and fungi. Mutations in this gene cause hemochromatosis type 2B, also known as juvenile hemochromatosis, a disease caused by severe iron overload that results in cardiomyopathy, cirrhosis, and endocrine failure. [provided by RefSeq, Oct 2014]

Poids moléculaire: predicted molecular mass of 28.3 kDa after removal of the signal peptide. The apparent molecular mass of HAMP(65-84)-hFc is 25-35 kDa due to glycosylation.

UniProt: P81172

Pathways: Hormone Activity, Transition Metal Ion Homeostasis