NPC2 Protein (AA 20-151) (His tag)
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- Antigène Voir toutes NPC2 Protéines
- NPC2 (Niemann-Pick Disease, Type C2 (NPC2))
- Type de proteíne
- Recombinant
- Attributs du protein
- AA 20-151
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Origine
- Humain
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Source
- HEK-293 Cells
- Purification/Conjugué
- Cette NPC2 protéine est marqué à la His tag.
- Fonction
- Human NPC2 Protein
- Séquence
- Glu20-Leu151
- Attributs du produit
- Recombinant Human NPC2 Protein is expressed from HEK293 with His tag at the C-terminus.It contains Glu20-Leu151.
- Pureté
- > 95 % as determined by Tris-Bis PAGE
- Stérilité
- 0.22 μm filtered
- niveau d'endotoxine
- Less than 1EU per μg by the LAL method.
- Top Product
- Discover our top product NPC2 Protéine
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- Restrictions
- For Research Use only
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- Format
- Lyophilized
- Reconstitution
- Centrifuge the tube before opening. Reconstituting to a concentration more than 100 μg/mL is recommended. Dissolve the lyophilized protein in distilled water.
- Buffer
- Lyophilized from 0.22 μm filtered solution in PBS ( pH 7.4). Normally 8 % trehalose is added as protectant before lyophilization.
- Stock
- -20 °C,-80 °C
- Stockage commentaire
- -20 to -80°C for 12 months as supplied from date of receipt., -80°C for 3-6 months after reconstitution., 2-8°C for 2-7 days after reconstitution., Recommend to aliquot the protein into smaller quantities for optimal storage. Please minimize freeze-thaw cycles.
- Date de péremption
- 12 months
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- Antigène
- NPC2 (Niemann-Pick Disease, Type C2 (NPC2))
- Autre désignation
- NPC2 (NPC2 Produits)
- Synonymes
- 2700012J19Rik Protein, AA408070 Protein, AU045843 Protein, HE1 Protein, EDDM1 Protein, re1 Protein, CE1 Protein, EPI-1 Protein, cb292 Protein, sb:cb292 Protein, NPC intracellular cholesterol transporter 2 Protein, Niemann-Pick disease, type C2 Protein, Npc2 Protein, NPC2 Protein, npc2 Protein
- Sujet
- The Niemann Pick type C (NPC) proteins, NPC1 and NPC2, are involved in the lysosomal storage disease, NPC disease. The formation of a NPC1⁻NPC2 protein⁻protein complex is believed to be necessary for the transfer of cholesterol and lipids out of the late endosomal (LE)/lysosomal (Lys) compartments. Mutations in either NPC1 or NPC2 can lead to an accumulation of cholesterol and lipids in the LE/Lys, the primary phenotype of the NPC disease.
- Poids moléculaire
- 15.67 kDa. Due to glycosylation, the protein migrates to 21-24 kDa and 27-35 kDa kDa based on Tris-Bis PAGE result.
- Pathways
- SARS-CoV-2 Protein Interactome
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