IL-21 Protein (AA 1-154) (His tag)

N° du produit ABIN7505764

Détail du produit

Antigène: IL-21 (IL21) (Interleukin 21 (IL21))

Type de proteíne: Recombinant

Attributs du protein: AA 1-154

Origine: Lapin

Source: HEK-293 Cells

Purification/Conjugué: Cette IL-21 protéine est marqué à la His tag.

Séquence: Met1-Leu154

Attributs du produit: A DNA sequence encoding theRabbit IL21 protein (G1T948) (Met1-Leu154) was expressed with a C-His.

Pureté: >95 % as determined by reducing SDS-PAGE.

Information d'application

Restrictions: For Research Use only

Stockage

Format: Lyophilized

Buffer: Lyophilized from sterile PBS, pH 7.4.

Stock: 4 °C,-20 °C,-80 °C

Stockage commentaire: Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.

Date de péremption: 12 months

Détail du antigène

Antigène: IL-21 (IL21) (Interleukin 21 (IL21))

Autre désignation: IL21 (IL21 Produits)

Synonymes: IL-21 Protein, Za11 Protein, interleukin 21 Protein, IL21 Protein, Il21 Protein

Sujet:

Background: IL21 belongs to the IL-15/IL-21 family. It is a cytokine with immunoregulatory activity. Cytokines are proteinaceous signaling compounds that are major mediators of the immune response. They control many different cellular functions including proliferation, differentiation, and cell survival/apoptosis but are also involved in several pathophysiological processes including viral infections and autoimmune diseases. Cytokines are synthesized under various stimuli by a variety of cells of both the innate (monocytes, macrophages, dendritic cells) and adaptive (T- and B-cells) immune systems. IL21 is expressed in activated CD4-positive T-cells but not in CD8-positive T-cells, B-cells, or monocytes. It may promote the transition between innate and adaptive immunity. IL-21 has been tried as a therapy for alleviating allergic responses. It can significantly decrease pro-inflammatory cytokines produced by T cells in addition to decreasing IgE levels in a mouse model for rhinitis (nasal passage inflammation).

Synonym: Interleukin-21,IL 21,IL-21

Poids moléculaire: 14.3 kDa

UniProt: G1T948

Pathways: Signalistation JAK/STAT, Regulation of Leukocyte Mediated Immunity, Positive Regulation of Immune Effector Process, Production of Molecular Mediator of Immune Response