CD46 Protein (CD46) (His tag)

N° du produit ABIN7534453

Détail du produit

Antigène: CD46

Type de proteíne: Recombinant

Origine: Humain

Source: HEK-293 Cells

Purification/Conjugué: Cette CD46 protéine est marqué à la His tag.

Fonction: Recombinant Human CD46 Protein

Séquence: CEEPPTFEAM ELIGKPKPYY EIGERVDYKC KKGYFYIPPL ATHTICDRNH TWLPVSDDAC YRETCPYIRD PLNGQAVPAN GTYEFGYQMH FICNEGYYLI GEEILYCELK GSVAIWSGKP PICEKVLCTP PPKIKNGKHT FSEVEVFEYL DAVTYSCDPA PGPDPFSLIG ESTIYCGDNS VWSRAAPECK VVKCRFPVVE NGKQISGFGK KFYYKATVMF ECDKGFYLDG SDTIVCDSNS TWDPPVPKCL KVSTSSTTKS PASSASGPRP TYKPPVSNYP GYPKPEEGIL DSLD

Specificité: Cys35-Asp328

Pureté: > 90 % by SDS-PAGE.

Stérilité: 0.22 μm filtered

niveau d'endotoxine: < 0.1 EU/μg of the protein by LAL method.

Information d'application

Restrictions: For Research Use only

Stockage

Format: Lyophilized

Reconstitution: Centrifuge the vial before opening. Reconstitute to a concentration of 0.1-0.5 mg/mL in sterile distilled water. Avoid votex or vigorously pipetting the protein. For long term storage, it is recommended to add a carrier protein or stablizer (e.g. 0.1 % BSA, 5 % HSA, 10 % FBS or 5 % Trehalose), and aliquot the reconstituted protein solution to minimize free-thaw cycles.

Concentration: 1 mg/mL

Buffer: Lyophilized from a 0.22 μm filtered solution of PBS, pH 7.4.

Stock: -20 °C,-80 °C

Stockage commentaire: Store the lyophilized protein at -20°C to -80 °C for long term.
After reconstitution, the protein solution is stable at -20 °C for 3 months, at 2-8 °C for up to 1 week.

Détail du antigène

Antigène: CD46

Autre désignation: CD46 (CD46 Produits)

Synonymes: AHUS2 Protein, MCP Protein, MIC10 Protein, TLX Protein, TRA2.10 Protein, Mcp Protein, CD46 Protein, CD46 molecule Protein, CD46 antigen, complement regulatory protein Protein, CD46 molecule, complement regulatory protein Protein, membrane cofactor protein-like Protein, CD46 Protein, Cd46 Protein, LOC100341359 Protein, LOC103789310 Protein

Sujet:

Description: The recombinant human CD46 consists of 305 amino acids with a molecular weight of 34 kDa. The apparent molecular mass of recombinant human CD46 is about 55-60 kDa in SDS-PAGE under reducing conditions due to glycosylation.CD46 is also known as MCP and is a type I membrane protein that functions as a cofactor for Complement Factor I-mediated inactivation of complement components C3b and C4b. CD46 is expressed in white blood cells, platelets, epithelial cells, and fibroblasts. In T-cells by binding to CD46, A number of viral and bacterial pathogens seem to exploit this property and directly induce an immunosuppressive phenotype. Defects in CD46 are a cause of susceptibility to hemolytic uremic syndrome atypical type 2 (AHUS2),a disease characterized by uncontrolled complement activation.

Name: AHUS2,MCP,MIC10,TLX,TRA2.10,CD46

ID gène: 4179

UniProt: P15529-11

Pathways: Regulation of Actin Filament Polymerization