Adipsin Protein (His tag)

N° du produit ABIN7535340

Détail du produit

Antigène: Adipsin (CFD) (Complement Factor D (CFD))

Type de proteíne: Recombinant

Activité biologique: Active

Origine: Humain

Source: HEK-293 Cells

Purification/Conjugué: Cette Adipsin protéine est marqué à la His tag.

Fonction: Active Recombinant Human Complement factor D/CFD Protein

Séquence: ILGGREAEAH ARPYMASVQL NGAHLCGGVL VAEQWVLSAA HCLEDAADGK VQVLLGAHSL SQPEPSKRLY DVLRAVPHPD SQPDTIDHDL LLLQLSEKAT LGPAVRPLPW QRVDRDVAPG TLCDVAGWGI VNHAGRRPDS LQHVLLPVLD RATCNRRTHH DGAITERLMC AESNRRDSCK GDSGGPLVCG GVLEGVVTSG SRVCGNRKKP GIYTRVASYA AWIDSVLA

Specificité: Ile26-Ala253

Pureté: > 95 % by SDS-PAGE.

Stérilité: 0.22 μm filtered

niveau d'endotoxine: <0.1EU/μg

Biological Activity Comment: Measured by its ability to cleave a colorimetric peptide substrate, N-carbobenzyloxy-Lys-ThioBenzyl ester (Z-Lys-SBzl), in the presence of 5,5'Dithio-bis (2-nitrobenzoic acid) (DTNB). The specific activity is >452.49 pmol/min/μg.

Information d'application

Restrictions: For Research Use only

Stockage

Format: Lyophilized

Reconstitution: Centrifuge the vial before opening. Reconstitute to a concentration of 0.1-0.5 mg/mL in sterile distilled water. Avoid votex or vigorously pipetting the protein. For long term storage, it is recommended to add a carrier protein or stablizer (e.g. 0.1 % BSA, 5 % HSA, 10 % FBS or 5 % Trehalose), and aliquot the reconstituted protein solution to minimize free-thaw cycles.

Buffer: Lyophilized from a 0.22 μm filtered solution of PBS, pH 7.4.

Stock: -20 °C,-80 °C

Stockage commentaire: Store the lyophilized protein at -20°C to -80°C for long term.|After reconstitution, the protein solution is stable at -20°C for 3 months, at 2-8°C for up to 1 week.

Détail du antigène

Antigène: Adipsin (CFD) (Complement Factor D (CFD))

Autre désignation: Complement factor D/CFD (CFD Produits)

Synonymes: ADIPSIN Protein, ADN Protein, DF Protein, PFD Protein, Adn Protein, Df Protein, EVE Protein, CFD Protein, adipsin Protein, pfd Protein, cfdl Protein, wu:fb61f12 Protein, zgc:109940 Protein, 10.5 Protein, 10.9 Protein, 14.10 Protein, 20.35 Protein, CG2328 Protein, Dmel\\CG2328 Protein, E(eve) Protein, Eve Protein, F Protein, V Protein, VI Protein, eve2 Protein, even Protein, l(2)46CFg Protein, l(2)46CFh Protein, l(2)46CFj Protein, l(2)46CFp Protein, l(2)46Ce Protein, l(2)46Cg Protein, complement factor D Protein, complement factor D (adipsin) Protein, complement factor D (adipsin) L homeolog Protein, even skipped Protein, CFD Protein, Cfd Protein, cfd.L Protein, cfd Protein, eve Protein

Sujet:

Description: Complement factor D, also known as Adipsin, C3 convertase activator, Properdin factor D and CFD is a secreted protein which belongs to thepeptidase S1 family. CFD/Adipsin contains onepeptidase S1 domain. Complement factor D ( CFD/Adipsin ) is a component of the alternative complement pathway best known for its role in humoral suppression of infectious agents. Complement factor D ( CFD/Adipsin ) has a high level of expression in fat, suggesting a role for adipose tissue in immune system biology. This protein is also a serine protease that is secreted by adipocytes into the bloodstream. Complement factor D ( CFD/Adipsin ) cleaves factor B when the latter is complexed with factor C3b, activating the C3bbb complex, which then becomes the C3 convertase of the alternate pathway. Its function is homologous to that of C1s in the classical pathway. Complement factor D ( CFD/Adipsin ) is a serine protease that stimulates glucose transport for triglyceride accumulation in fats cells and inhibits lipolysis. Defects in CFD/Adipsin are the cause of complement factor D deficiency (CFD deficiency) which predisposes to invasive meningococcal disease.

Name: CFD,ADIPSIN,ADN,DF,PFD

ID gène: 1675

UniProt: P00746

Pathways: Système du Complément