GFRA1 Protein (Fc Tag,His tag)

N° du produit ABIN7520038

Détail du produit

Antigène: GFRA1 (GDNF Family Receptor alpha 1 (GFRA1))

Type de proteíne: Recombinant

Activité biologique: Active

Origine: Humain

Source: HEK-293 Cells

Purification/Conjugué: Cette GFRA1 protéine est marqué à la Fc Tag,His tag.

Fonction: Active Recombinant Human GDNFR-alpha-1/GFRA1 Protein

Séquence: AEVSGGDRLD CVKASDQCLK EQSCSTKYRT LRQCVAGKET NFSLASGLEA KDECRSAMEA LKQKSLYNCR CKRGMKKEKN CLRIYWSMYQ SLQGNDLLED SPYEPVNSRL SDIFRVVPFI SVEHIPKGNN CLDAAKACNL DDICKKYRSA YITPCTTSVS NDVCNRRKCH KALRQFFDKV PAKHSYGMLF CSCRDIACTE RRRQTIVPVC SYEEREKPNC LNLQDSCKTN YICRSRLADF FTNCQPESRS VSSCLKENYA DCLLAYSGLI GTVMTPNYID SSSLSVAPWC DCSNSGNDLE ECLKFLNFFK DNTCLKNAIQ AFGNGSDVTV WQPAFPVQTT TATTTTALRV KNKPLGPAGS ENEIPTHVLP PCANLQAQKL KSNVSGNTHL CISNGNYEKE GLGASSHITT K

Specificité: Ala19-Lys429

Pureté: > 80 % by SDS-PAGE.

Stérilité: 0.22 μm filtered

niveau d'endotoxine: < 1.0 EU/μg of the protein by LAL method.

Biological Activity Comment: Measured by its binding ability in a functional ELISA. Immobilized Human GDNF at 1 μg/mL (100 μL/well) can bind Human GFRA1 with a linear range of 2-332 ng/mL.

Information d'application

Restrictions: For Research Use only

Stockage

Format: Lyophilized

Reconstitution: Centrifuge the vial before opening. Reconstitute to a concentration of 0.1-0.5 mg/mL in sterile distilled water. Avoid votex or vigorously pipetting the protein. For long term storage, it is recommended to add a carrier protein or stablizer (e.g. 0.1 % BSA, 5 % HSA, 10 % FBS or 5 % Trehalose), and aliquot the reconstituted protein solution to minimize free-thaw cycles.

Buffer: Lyophilized from a 0.22 μm filtered solution of PBS, pH 7.4.

Stock: -20 °C,-80 °C

Stockage commentaire: Store the lyophilized protein at -20°C to -80 °C for long term.
After reconstitution, the protein solution is stable at -20 °C for 3 months, at 2-8 °C for up to 1 week.

Détail du antigène

Antigène: GFRA1 (GDNF Family Receptor alpha 1 (GFRA1))

Autre désignation: GDNFR-alpha-1/GFRA1 (GFRA1 Produits)

Synonymes: gdnfr Protein, ret1l Protein, retl1 Protein, trnr1 Protein, gdnfra Protein, MGC122616 Protein, gfr-alpha-1 Protein, GDNFR Protein, GDNFRA Protein, GFR-ALPHA-1 Protein, RET1L Protein, RETL1 Protein, TRNR1 Protein, GDNFRALPHA Protein, GFRA1 Protein, AU042498 Protein, gfralpha1a Protein, zgc:110129 Protein, GDNF family receptor alpha 1 Protein, glial cell line derived neurotrophic factor family receptor alpha 1 Protein, gdnf family receptor alpha 1a Protein, gfra1 Protein, GFRA1 Protein, Gfra1 Protein, gfra1a Protein

Sujet:

Description: This protein is a member of the glial cell line-derived neurotrophic factor receptor (GDNFR) family of proteins. The encoded preproprotein is proteolytically processed to generate the mature receptor. Glial cell line-derived neurotrophic factor (GDNF) and neurturin (NTN) are two structurally related, potent neurotrophic factors that play key roles in the control of neuron survival and differentiation. This receptor is a glycosylphosphatidylinositol (GPI)-linked cell surface receptor for both GDNF and NTN, and mediates activation of the RET tyrosine kinase receptor. This gene is a candidate gene for Hirschsprung disease. Alternative splicing results in multiple transcript variants, at least one of which encodes a preproprotein that is proteolytically processed.

Name: GFRA1,GDNFR,GDNFRA,GFR-ALPHA-1,RET1L,RETL1,TRNR1

ID gène: 2674

UniProt: P56159