HHIP Protein (His tag)

N° du produit ABIN7534321

Détail du produit

Antigène: HHIP (Hedgehog Interacting Protein (HHIP))

Type de proteíne: Recombinant

Origine: Humain

Source: HEK-293 Cells

Purification/Conjugué: Cette HHIP protéine est marqué à la His tag.

Fonction: Recombinant Human Hedgehog-interacting protein/HHIP Protein

Séquence: FFEGDAKFGE RNEGSGARRR RCLNGNPPKR LKRRDRRMMS QLELLSGGEM LCGGFYPRLS CCLRSDSPGL GRLENKIFSV TNNTECGKLL EEIKCALCSP HSQSLFHSPE REVLERDLVL PLLCKDYCKE FFYTCRGHIP GFLQTTADEF CFYYARKDGG LCFPDFPRKQ VRGPASNYLD QMEEYDKVEE ISRKHKHNCF CIQEVVSGLR QPVGALHSGD GSQRLFILEK EGYVKILTPE GEIFKEPYLD IHKLVQSGIK GGDERGLLSL AFHPNYKKNG KLYVSYTTNQ ERWAIGPHDH ILRVVEYTVS RKNPHQVDLR TARVFLEVAE LHRKHLGGQL LFGPDGFLYI ILGDGMITLD DMEEMDGLSD FTGSVLRLDV DTDMCNVPYS IPRSNPHFNS TNQPPEVFAH GLHDPGRCAV DRHPTDININ LTILCSDSNG KNRSSARILQ IIKGKDYESE PSLLEFKPFS NGPLVGGFVY RGCQSERLYG SYVFGDRNGN FLTLQQSPVT KQWQEKPLCL GTSGSCRGYF SGHILGFGED ELGEVYILSS SKSMTQTHNG KLYKIVDPKR PLMPEECRAT VQPAQTLTSE CSRLCRNGYC TPTGKCCCSP GWEGDFCRTA KCEPACRHGG VCVRPNKCLC KKGYLGPQCE QVD

Specificité: Phe18-Asp670

Pureté: > 90 % by SDS-PAGE.

Stérilité: 0.22 μm filtered

niveau d'endotoxine: < 0.1 EU/μg of the protein by LAL method.

Information d'application

Restrictions: For Research Use only

Stockage

Format: Lyophilized

Reconstitution: Centrifuge the vial before opening. Reconstitute to a concentration of 0.1-0.5 mg/mL in sterile distilled water. Avoid votex or vigorously pipetting the protein. For long term storage, it is recommended to add a carrier protein or stablizer (e.g. 0.1 % BSA, 5 % HSA, 10 % FBS or 5 % Trehalose), and aliquot the reconstituted protein solution to minimize free-thaw cycles.

Buffer: Lyophilized from a 0.22 μm filtered solution of PBS, pH 7.4.

Stock: -20 °C,-80 °C

Stockage commentaire: Store the lyophilized protein at -20°C to -80 °C for long term.
After reconstitution, the protein solution is stable at -20 °C for 3 months, at 2-8 °C for up to 1 week.

Détail du antigène

Antigène: HHIP (Hedgehog Interacting Protein (HHIP))

Autre désignation: Hedgehog-interacting protein/HHIP (HHIP Produits)

Synonymes: fd99f01 Protein, wu:fc52e12 Protein, wu:fd99f01 Protein, zgc:153478 Protein, HIP Protein, Xhip Protein, hip Protein, RGD1564108 Protein, Hhip1 Protein, hedgehog interacting protein Protein, hedgehog interacting protein L homeolog Protein, Hedgehog-interacting protein Protein, hhip Protein, HHIP Protein, hhip.L Protein, Hhip Protein

Sujet:

Description: Hip (Hedgehog-interacting protein) is a type I transmembrane protein identified for its ability to bind biologically active Sonic Hedgehog.The hedgehog (HH) proteins are evolutionarily conserved protein, which are important morphogens for a wide range of developmental processes, including anteroposterior patterns of limbs and regulation of left-right asymmetry in embryonic development. Multiple cell-surface receptors are responsible for transducing and/or regulating HH signals. The Hip protein is a highly conserved, vertebrate-specific inhibitor of HH signaling. It interacts with all three HH family members, SHH, IHH and DHH. Two single nucleotide polymorphisms (SNPs) near this gene are significantly associated with risk of chronic obstructive pulmonary disease (COPD). A single nucleotide polymorphism in this gene is also strongly associated with human height.

Name: HHIP,HIP

ID gène: 64399

UniProt: Q96QV1

Pathways: Signalisation Hedgehog