IFNA2 Protein (His tag)

N° du produit ABIN7535547

Détail du produit

Antigène: IFNA2 (Interferon, alpha 2 (IFNA2))

Type de proteíne: Recombinant

Activité biologique: Active

Origine: Humain

Source: HEK-293 Cells

Purification/Conjugué: Cette IFNA2 protéine est marqué à la His tag.

Fonction: Active Recombinant Human IFN-alpha 2 Protein

Séquence: CDLPQTHSLG SRRTLMLLAQ MRKISLFSCL KDRHDFGFPQ EEFGNQFQKA ETIPVLHEMI QQIFNLFSTK DSSAAWDETL LDKFYTELYQ QLNDLEACVI QGVGVTETPL MKEDSILAVR KYFQRITLYL KEKKYSPCAW EVVRAEIMRS FSLSTNLQES LRSKE

Specificité: Cys24-Glu188

Pureté: > 95 % by SDS-PAGE.

Stérilité: 0.22 μm filtered

Biological Activity Comment: 1.Measured by its binding ability in a functional ELISA.Immobilized Human IFNA2 at 2 μg/mL (100 μL/well) can bind Human IFNAR2 with a linear range of 0.2-617ng/mL.|2.Recombinant human IFN-α2 (10 ng/mL) was used to treat HCT116 cells. Western-blot result showed that both the level of phosphorylated STAT1 and STAT3 were increased, indicating the stimulation was successful.(Customer Feedback Data)

Information d'application

Restrictions: For Research Use only

Stockage

Format: Lyophilized

Reconstitution: Centrifuge the vial before opening. Reconstitute to a concentration of 0.1-0.5 mg/mL in sterile distilled water. Avoid votex or vigorously pipetting the protein. For long term storage, it is recommended to add a carrier protein or stablizer (e.g. 0.1 % BSA, 5 % HSA, 10 % FBS or 5 % Trehalose), and aliquot the reconstituted protein solution to minimize free-thaw cycles.

Buffer: Lyophilized from a 0.22 μm filtered solution of PBS, pH 7.4.

Stock: -20 °C,-80 °C

Stockage commentaire: Store the lyophilized protein at -20°C to -80°C for long term.|After reconstitution, the protein solution is stable at -20°C for 3 months, at 2-8°C for up to 1 week.

Détail du antigène

Antigène: IFNA2 (Interferon, alpha 2 (IFNA2))

Autre désignation: IFN-alpha 2 (IFNA2 Produits)

Synonymes: IFN-alphaA Protein, IFNA Protein, IFNA2B Protein, INFA2 Protein, Ifa2 Protein, IFNA2 Protein, interferon alpha 2 Protein, interferon, alpha 2 Protein, interferon-alpha-2 Protein, interferon alpha-2 Protein, IFNA2 Protein, Ifna2 Protein, ifna2 Protein, IFN-ALPHA2 Protein, LOC102142148 Protein

Sujet:

Description: IFNA2 (Interferon Alpha 2) is a Protein Coding gene. This gene is a member of the alpha interferon gene cluster on chromosome 9. The encoded protein is a cytokine produced in response to viral infection. Type I Interferons (IFNs) are well-known cytokines that exert antiviral activity, antitumor activity, and immunomodulatory effects. Interferon tau (IFNT), a type I IFN similar to alpha IFNs (IFNA), is the pregnancy recognition signal produced by the ruminant conceptus. Among the IFN-α genes, a total of 28 different sequence variants have been described. The three principal subtypes of IFNα-2 are designated α-2a, α-2b, and α-2c. IFNα-2b is being the predominant allele while IFNα-2a is less predominant and IFNα-2c only a minor allelic variant.

Name: IFNA2, IFN-alphaA, IFNA, IFNA2B, INFA2, interferon alpha-2,Interferon alpha 2 (IFN-α2),IFN-alphaA,IFNA,IFNA2B,INFA2

ID gène: 3440

UniProt: P01563

Pathways: Signalistation JAK/STAT, Regulation of Leukocyte Mediated Immunity, Production of Molecular Mediator of Immune Response, Hepatitis C