PTH1R Protein (His tag)

N° du produit ABIN7535432

Détail du produit

Antigène: PTH1R (Parathyroid Hormone 1 Receptor (PTH1R))

Type de proteíne: Recombinant

Origine: Humain

Source: HEK-293 Cells

Purification/Conjugué: Cette PTH1R protéine est marqué à la His tag.

Fonction: Recombinant Human PTH1R Protein

Séquence: DADDVMTKEE QIFLLHRAQA QCEKRLKEVL QRPASIMESD KGWTSASTSG KPRKDKASGK LYPESEEDKE APTGSRYRGR PCLPEWDHIL CWPLGAPGEV VAVPCPDYIY DFNHKGHAYR RCDRNGSWEL VPGHNRTWAN YSECVKFLTN ETREREVFDR LG

Specificité: Asp27-Gly188

Pureté: > 95 % by SDS-PAGE.

Stérilité: 0.22 μm filtered

niveau d'endotoxine: <0.1EU/μg

Information d'application

Restrictions: For Research Use only

Stockage

Format: Lyophilized

Reconstitution: Centrifuge the vial before opening. Reconstitute to a concentration of 0.1-0.5 mg/mL in sterile distilled water. Avoid votex or vigorously pipetting the protein. For long term storage, it is recommended to add a carrier protein or stablizer (e.g. 0.1 % BSA, 5 % HSA, 10 % FBS or 5 % Trehalose), and aliquot the reconstituted protein solution to minimize free-thaw cycles.

Buffer: Lyophilized from a 0.22 μm filtered solution of PBS, pH 7.4.

Stock: -20 °C,-80 °C

Stockage commentaire: Store the lyophilized protein at -20°C to -80°C for long term.|After reconstitution, the protein solution is stable at -20°C for 3 months, at 2-8°C for up to 1 week.

Détail du antigène

Antigène: PTH1R (Parathyroid Hormone 1 Receptor (PTH1R))

Autre désignation: PTH1R (PTH1R Produits)

Synonymes: PFE Protein, PTHR Protein, PTHR1 Protein, PPR Protein, Pthr Protein, Pthr1 Protein, pthr1 Protein, zPTH1R Protein, PTHrel Protein, PTH1 Protein, PTH Protein, parathyroid hormone 1 receptor Protein, parathyroid hormone 1 receptor a Protein, PTH1R Protein, Pth1r Protein, pth1ra Protein

Sujet:

Description: Parathyroid hormone / parathyroid hormone-related peptide receptor, also known as PTH / PTHrP type I receptor, PTH/PTHr receptor, Parathyroid hormone 1 receptor, PTH1 receptor, PTH1R and PTHR, is a multi-pass membrane protein which belongs to the G-protein coupled receptor 2 family. PTH1R is expressed in most tissues. It is most abundant in kidney, bone and liver. PTH1R is expressed in high levels in bone and kidney and regulates calcium ion homeostasis through activation of adenylate cyclase and phospholipase C. In bone, PTH1R is expressed on the surface of osteoblasts. When the receptor is activated, these cells in turn stimulate osteoclasts to ultimately increase the resorption rate. PTH1R is a receptor for parathyroid hormone and for parathyroid hormone-related peptide. The activity of PTH1R is mediated by G proteins which activate adenylyl cyclase and also a phosphatidylinositol-calcium second messenger system. Defects in PTH1R are the cause of Jansen metaphyseal chondrodysplasia (JMC), chondrodysplasia Blomstrand type (BOCD), enchondromatosis multiple (ENCHOM), Eiken skeletal dysplasia (EISD) and primary failure of tooth eruption (PFE).

Name: PTH1R,PFE,PTHR,PTHR1

ID gène: 5745

UniProt: Q03431

Pathways: Regulation of Carbohydrate Metabolic Process