SERPINA1
(serpin Peptidase Inhibitor, Clade A (Alpha-1 Antiproteinase, Antitrypsin), Member 1 (SERPINA1))
Type de proteíne
Native
Origine
Humain
Source
Human
Réactivité croisée (Details)
When tested with active-site titrated porcine pancreatic trypsin using Na-Benzoyl-L-Arginine-para-Nitroanilide Hydrochloride (L-BAPNA) as substrate, it is 75-100 % inihibitory.
Attributs du produit
Purified native Human alpha 1 Antitrypsin protein Protein Source: Human plasma
SERPINA1
Origine: Humain
Hôte: Human Cells
Recombinant
> 95 % as determined by reducing SDS-PAGE.
Indications d'application
Each Investigator should determine their own optimal working dilution for specific applications.
Restrictions
For Research Use only
Format
Lyophilized
Reconstitution
Reconstitute with distilled water.
Buffer
Lyophilized from 30 mM Na0 O4, pH 6.5, with 300 M NaCl.
Précaution d'utilisation
Donor samples were tested and found to be negative for HBsAg, anti-HCV, anti-HBc, and negative for anti-HIV 1 & 2. Nonetheless caution should be used when handling this material as there is a margin of error in all tests.
Conseil sur la manipulation
Avoid repeated freeze/thaw cycles.
Stock
-20 °C
Stockage commentaire
Aliquot and store at -20 °C.
Antigène
SERPINA1
(serpin Peptidase Inhibitor, Clade A (Alpha-1 Antiproteinase, Antitrypsin), Member 1 (SERPINA1))
AACT Protein, ACT Protein, GIG25 Protein, A1AT Protein, PI Protein, alpha-1-PI Protein, A1A Protein, AAT Protein, PI1 Protein, PRO2275 Protein, alpha1AT Protein, Pi Protein, Spi1 Protein, MGC64429 Protein, serpina1d Protein, Aps Protein, SERPINA3-5 Protein, serpin family A member 3 Protein, alpha-1-antiproteinase F precursor Protein, serpin family A member 1 Protein, alpha-1-antitrypsin Protein, calumenin Protein, serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1 S homeolog Protein, serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1 Protein, serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 5 Protein, SH2B adaptor protein 2 Protein, serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3 Protein, serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1 L homeolog Protein, SERPINA3 Protein, LOC100008973 Protein, SERPINA1 Protein, LOC100328621 Protein, CALU Protein, Serpina1 Protein, serpina1.S Protein, serpina1 Protein, SPIA5 Protein, Sh2b2 Protein, Calu Protein, serpina1.L Protein
Sujet
An acute-phase plasma protein found at 290 mg per 100 ml that functions as a protease inhibitor. Clinically, its deficiency is associated with two major diseases: pulmonary emphysema and early onset/juvenile hepatic cirrhosis. It is elevated in inflammatory conditions, malignancies, liver disease and pregnancy and also after surgical trauma and use of oral contraceptives. The simultaneous quantitative determination of alpha-1-PI and ceruloplasmin permits differential diagnosis of liver afflictions. Description: Human plasma. Alternative Names: A1-AT protein, alpha 1 protein, alpha-1 Antitrypsin protein, alpha-1-Antitrypsin, alpha-1-Antitrypsin protein, A1AT protein, alpha 1 Antitrypsin