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Our finding suggested that TAP1-rs1135216, TAP1-rs4148873, TAP2-rs2228396, TAP2-rs241447 and TAP2-rs4148873 might not be involved in cancer risk, but the T allele of TAP2-rs4148876 might be a potential biomarker for judging cancer risk [review, meta-analysis]
Our findings support the hypothesis that hsa-miR-1270 suppresses the production of TAP2 by binding to this SNP in the 3'-UTR of this gene
The present study illustrated that the carriage of LMP7 rs2071543-AA and TAP2 rs1800454-AA had a negative effect on treatment response to pegIFN-alpha/RBV among genotype 1 patient with chronic hepatitis C (CHC) in a Chinese Han population
In a meta-analyses of 6 studies with 415 cases and 659 controls, a significant association was found between TAP1-333Val, TAP1-637Gly, and TAP2-565Thr and ankylosing spondylitis compared with combined control group.
Both TAP1 and TAP2 overexpression in breast cancer might be an indicator of an aggressive breast tumor
We replicated the association between the rs2071473 genotype and TAP2 expression by using GTEx data and demonstrated that TAP2 is expressed by decidual stromal cells at the maternal-fetal interface.
Two eSNPs were associated with fecundability at a FDR of 5%; both were in the HLA region and were eQTLs for the TAP2 gene (P = 1.3x10-4) and the HLA-F gene (P = 4.0x10-4), respectively.
there was no significant difference with respect to the genotypic frequencies of the SNPs in PSMB8, TAP1, and TAP2 loci in Parkinson's disease patients
These results suggest that TAP2 polymorphisms influence TB susceptibility in a Japanese population.
TAP1/2 gene polymorphisms might be associated with pulmonary tuberculosis susceptibility among patients in Zahedan, southeast Iran.
Deletions of ABCB3 predict good tumor response to neoadjuvant chemotherapy in breast cancer.
TAP/TPN complex formation is driven by hydrophobic interactions via leucine zipper-like motifs.
cryo-electron microscopy structure of human TAP in complex with its inhibitor ICP47, a small protein produced by the herpes simplex virus I
TAP2, HLA-DOA, HLA-DOB, and tapasin loci are novel candidate regions for susceptibility to HCV infection and viral clearance in the Chinese population
Studies indicate that ABC transporters associated with antigen processing TAP1/2 (ABCB2/3) is a crucial element of the adaptive immune system.
We showed that TAP2 gene has an association with pulmonary tuberculosis in Koreans.
Our meta-analyses suggested that TAP2-379Ile allele was significantly associated with a 59% increased risk for rheumatoid arthritis
Results suggested an association between TAP2-565 polymorphism and chronic lymphoid leukemia (CLL). TAP2-665 GG genotype might be a risk factor for CLL, chronic myeloblastic leukemia, and multiple myeloma.
TAP1 AND TAP2 polymorphisms are associated with a reduced risk for developing cervical intraepithelial neoplasia.
Three tapasin binding sites on TAP have been described, two of which are located in the N-terminal domains of TAP1 and TAP2.
this study show that a new mouse strain with a single point mutation (Tap2 knock-out strain) shows impaired survival of macrophage survival following peritoneal iflammation
The Rose strain has an A to T substitution in exon 10 of TAP1, resulting in an asparagine to valine substitution at position 643; defective TAP expression mice have very low major histocompatibility complex-I cell-surface expression, and few CD8 T cells.
A major role for tapasin as a stabilizer of the TAP peptide transporter and consequences for MHC class I expression
The membrane-associated protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MDR/TAP subfamily. Members of the MDR/TAP subfamily are involved in multidrug resistance. This gene is located 7 kb telomeric to gene family member ABCB2. The protein encoded by this gene is involved in antigen presentation. This protein forms a heterodimer with ABCB2 in order to transport peptides from the cytoplasm to the endoplasmic reticulum. Mutations in this gene may be associated with ankylosing spondylitis, insulin-dependent diabetes mellitus, and celiac disease. Alternative splicing of this gene produces two products which differ in peptide selectivity and level of restoration of surface expression of MHC class I molecules.
ABC transporter, MHC 2
, ATP-binding cassette, sub-family B (MDR/TAP), member 3
, antigen peptide transporter 2
, peptide supply factor 2
, peptide transporter PSF2
, peptide transporter involved in antigen processing 2
, really interesting new gene 11 protein
, transporter 2, ABC (ATP binding cassette)
, ATP dependent transport protein family member
, ATP-binding cassette sub-family B member 3
, histocompatibility antigen modifier 2
, Transporter 2 ABC (ATP binding cassette)
, transporter 2, ABC(ATP binding cassette)
, transporter 2, ATP-binding cassette, sub-family B