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Human TNFSF13 Protein expressed in HEK-293 Cells - ABIN1344412
Litinskiy, Nardelli, Hilbert, He, Schaffer, Casali, Cerutti: DCs induce CD40-independent immunoglobulin class switching through BLyS and APRIL. dans Nature immunology 2002
Show all 9 Pubmed References
Human TNFSF13 Protein expressed in Wheat germ - ABIN1323221
Chihara, Aranami, Sato, Miyazaki, Miyake, Okamoto, Ogawa, Toda, Yamamura: Interleukin 6 signaling promotes anti-aquaporin 4 autoantibody production from plasmablasts in neuromyelitis optica. dans Proceedings of the National Academy of Sciences of the United States of America 2011
Human TNFSF13 Protein expressed in HEK-293 Cells - ABIN1344410
Huard, Tran, Benkhoucha, Manzin-Lorenzi, Santiago-Raber: Selective APRIL blockade delays systemic lupus erythematosus in mouse. dans PLoS ONE 2012
Authors have investigated the roles of APRIL (tumor necrosis factor superfamily member [TNFSF] 13) and BAFF (TNFSF13B) in intestinal Ig induction. Peyer's patches (PPs) are, at least in part, an inductive site for Igs, including IgA.
TNFSF13, SPATC1L, SLC22A25 and SALL4 may thus be novel susceptibility loci for atrial fibrillation in the Japanese population
The results suggest that increased levels of BAFF and APRIL produced in the central nervous system may influence the development of anti-neutrophil cytoplasmic antibody-hypertrophic pachymeningitis.
The genetic variations and gene expression level of TNFSF13 are associated with the susceptibility and severity of IgA nephropathy in a Han Chinese population.
APRIL levels are associated with disease activity in human chronic graft-versus-host disease.
APRIL but not BLyS promotes IL-10 production by CpG-activated B cells and enhances the regulatory role of B cells on T cells.
BCMA has other contributors for ligands binding except DxL motif. The affinity of BCMA for APRIL higher than for BAFF may be caused by the segment outside of the conservative DxL motif. Moreover, the exposition of new binding modes of BCMA2 interacting with APRIL may establish the foundation of designing novel drugs in the future
APRIL transgenic mice infected by Helicobacter species may represent a novel animal model of gastric lymphomagenesis.
ApoE-/-APRIL-Tg mice have increased oxLDL-specific serum IgM levels, potentially mediated via an increase in B1a lymphocytes
Results showed that chemokine-mediated recruitment of neutrophils secreting the tumor-promoting factor APRIL mediates DLBCL progression.
This study showed that both BAFF and APRIL levels were increased in CSF of patients with anti-NMDAR encephalitis.
The results demonstrated that rs11552708 of the APRIL gene is not associated with Systemic lupus erythematosus (SLE) susceptibility in Iranian children. Likewise, these findings suggest that APRIL antagonist could be a potential therapeutic target to control SLE in children.
New molecular mechanisms of in vivo Multiple Myeloma (MM) growth and immunosuppression critically dependent on BCMA and APRIL in the Bone marrow microenvironment, further supporting targeting this prominent pathway in MM.
Urinary APRIL (uAPRIL) and BAFF (uBAFF) levels were raised significantly in AN.
High expression of APRIL is associated with hepatocellular carcinoma.
Data did not detect any significant association with SNPs of APRIL, SPATA8, PDGFRA, and POLB with Systemic Lupus Erythematosus in Chinese Han Population.
Recombinant human APRIL (rhAPRIL) could rescue HCC cell proliferation inhibited by miR-383.
Host-derived proteins pp32 and APRIL interact with a free form of influenza virus RNA-dependent RNA polymerase and preferentially upregulates viral RNA synthesis rather than cRNA synthesis.
high expression of APRIL in clear cell renal cell carcinoma was correlated with high Fuhrman nuclear grade, high pathologic stage, and poor overall and cancer-specific survival of the patients
TNFSF13 and FDX1 have potential roles in IgAN in the Han Chinese population. This information may be useful in the development of early prognostics for IgAN.
p40, a Lactobacillus rhamnosus-derived protein upregulates EGFR-dependent APRIL expression in intestinal epithelial cells, which may contribute to promoting IgA production
this study identifies APRIL as a new target involved in B-cell activation, in the maintenance of plasma cell survival and subsequent increased autoantibody production that sustains lupus development in mice
Our data indicate that APRIL contributes to fibrotic scar formation after spinal cord injury by mediating the inflammatory response
this is the first study to implicate the APRIL signal transduction pathway in the pathogenesis of nephrogenic IgA production. Moreover, our findings identify APRIL as a potential target of therapy.
the elevated presence of APRIL and BLyS in B cell-rich areas of chronically inflamed gingiva suggests that these cytokines may contribute to bone loss by promoting the survival and persistence of RANKL-expressing B cells/plasma cells.
myelopoiesis dysregulation characterized by an increased proportion of precursor cells occurs in MM patients. Such dysregulation correlates with a stable expression of the MM-promoting factor APRIL in infiltrated BM.
B cell activating factor (BAFF) and a proliferation inducing ligand (APRIL) mediate CD40-independent help by memory CD4 T cells in transplantations.
Heteromers consisting of one BAFF and two APRIL bind to receptor TACI, BCMA but not to BAFFR.
Immunization of mice with a DNA vaccine encoding BAFF or APRIL multitrimers, together with interleukin 12 and membrane-bound HIV-1 Env gp140, induced neutralizing antibodies against tier 1 and tier 2 (vaccine strain) viruses.
APRIL mediates peritoneal B-1 cell homeostasis.
APRIL selectively enhances axonal growth by activating ERK signaling and PI3-kinase/Akt/GSK-3beta signaling.
Data indicate that APRIL expression accelerates the onset of TCL1-driven leukemia formation mainly through TACI activation.
The ability of TACI-Fc to activate reverse signalling through BAFF and APRIL, was investigated.
CD1d-restricted invariant NKT cell-derived BAFF and APRIL each contribute to survival of plasma cells induced by immunization.
The TNF family member APRIL dampens collagen-induced arthritis.
NF-kappaB mediates APRIL-induced HoxC4 transcription.
APRIL is dispensable for the development of full-blown SLE in NZM mice.
Grafted human colorectal tumor growth and metastasis were inhibited while tumor cell apoptosis and necrosis were induced after in vivo APRIL siRNA injection into nude mice.
April production, both in the human and mouse systems, peaks in myeloid precursor cells, before dropping in fully mature granulocytes.
Disruption of heparan sulfate proteoglycan conformation perturbs B-cell maturation and APRIL-mediated plasma cell survival.
Although proliferation-inducing ligand TNFSF13/APRIL expression is dispensable for B cell development in the bone marrow, it is required for B cell development in gut-associated lymphoid tissue.
Cloning and expression analysis of a proliferation-inducing ligand (APRIL) provides the basis for investigation of its role in regulating rabbit B-lymphocyte development and immune responses.
The protein encoded by this gene is a member of the tumor necrosis factor (TNF) ligand family. This protein is a ligand for TNFRSF17/BCMA, a member of the TNF receptor family. This protein and its receptor are both found to be important for B cell development. In vitro experiments suggested that this protein may be able to induce apoptosis through its interaction with other TNF receptor family proteins such as TNFRSF6/FAS and TNFRSF14/HVEM. Alternative splicing results in multiple transcript variants. Some transcripts that skip the last exon of the upstream gene (TNFSF12) and continue into the second exon of this gene have been identified\; such read-through transcripts are contained in GeneID 407977, TNFSF12-TNFSF13.
TNF- and APOL-related leukocyte expressed ligand 2
, a proliferation-inducing ligand
, tumor necrosis factor ligand superfamily member 13
, tumor necrosis factor-like protein ZTNF2
, tumor necrosis factor-related death ligand-1
, SLAN protein
, Acidic leucine-rich nuclear phosphoprotein 32 family member B
, TNF superfamily member 13
, A proliferation-inducing ligand
, tumor necrosis factor ligand superfamily member 13 isoform alpha proprotein
, tumor necrosis factor (ligand) superfamily, member 13
, tumor necrosis factor superfamily member 13
, proliferation-inducing ligand
, tumor necrosis factor ligand 7B