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PMCA4b overexpression preserves cardiac function following ischemia reperfusion injury, heightens cardiac performance and limits infarct progression, cardiac hypertrophy and heart failure.
Data (including data from studies in knockout mice) suggest that renalase functions as a protective plasma protein that reduces pancreatic acinar cell injury and prevents pancreatitis via interactions with plasma membrane calcium ATPase PMCA4b.
Na+, K+-ATPase and Ca2+-ATPase activity and Na+, K+-ATPase alpha4 and PMCA4 isoform expressions examined in asthenozoospermic men
study provides evidence for the therapeutic potential of targeting PMCA4 to improve VEGF-based pro-angiogenic interventions. This goal will require the development of refined, highly selective versions of ATA, or the identification of novel PMCA4 inhibitors.
data suggest that an altered regulation of gene expression is responsible for the reduced RBC-PMCA4b levels that is probably linked to the development of human disease-related phenotypes.
the ATP2B4 enhancer mediates red blood cell hydration and malaria susceptibility
Increased plasma membrane abundance of PMCA4b in vemurafenib-treated BRAF mutant cells is associated with enhanced Ca2+ clearance.
The role of heterozygous variants of ATP2B4 is regulated by HSPG2 protein with transcription factors in bone formation through modulation of calcium signaling.
RNA sequencing identified a novel ATPase, Ca2+ transporting, plasma membrane 4(ATP2B4)-protein kinase C-alpha (PRKCA) fusion transcript.
our data show that CD147 interacts via its immunomodulatory domains with PMCA4 to bypass TCR proximal signaling and inhibit IL-2 expression.
We also nominate a new candidate gene in congenital arrhythmia, ATP2B4, and provide experimental evidence of a regulatory role for variants discovered using this framework.
p.R268Q mutation in PMCA4 resulted in functional changes in calcium homeostasis in human neuronal cells. This suggests that calcium dysregulation may be associated with the pathogenesis of Familial spastic paraplegia
The slowly activating PMCA4b isoform produced long-lasting Ca2+ oscillations in response to store-operated Ca2+ entry.
While PMCA1b has a housekeeping function in colon cancer cells, PMCA4b participates in the reorganization of the calcium signaling machinery during cell differentiation.
Mechanism of PMCA4 that creates lipid asymmetry is well understood in terms of ATP hydrolysis; molecular models exist for trajectory taken by phospholipid substrates through the enzyme. [review-like article]
Calcium dysregulation resulting from a novel missense mutation (c.803G>A, p.R268Q) in the PMCA4 (ATP2B4) gene may be associated with the pathogenesis of familial spastic paraplegia.
PMCA4 inhibits the activation of the calcineurin/NFAT pathway on VEGF stimulation of endothelial cells, leading to a significant attenuation of VEGF-mediated angiogenesis.
A significant relationship between ATP2B4 gene expression and the tumor location was detected in patients with rectum tumors.
a di-leucine-like internalization signal at the C-tail of PMCA4b, is reported.
the role of PMCA4 in the regulation of blood pressure was examined.
PMCA4 co-ordinates both Ca2+ and NO signaling in mammalian sperm, to control sperm motility.
PMCA4 has no discernible role in normal renal Ca2+ handling as no urinary Ca2+ wasting was observed. Further investigation of the exact role of PMCA4 in the distal convoluted tubule and connecting tubule is required
PMCA4 regulates the development of cardiac hypertrophy and provide proof of principle for a therapeutic approach to treat this condition.
Electron microscopy demonstrated Pmca4 localization in distal nephron cells at both the basolateral membrane and intracellular perinuclear compartments but not submembranous vesicles
Findings indicate an important regulation of plasma membrane Ca(2+)-ATPase (PMCA) by Homer2 protein that has a central role on PMCA-mediated Ca(2+) signaling in parotid acinar cells.
Oviductal exosomes play significant role in post-testicular sperm acquisition of PMCA4a which is essential for hyperactivated motility and fertility.
this study concludes that Ca(2+) efflux activity of PMCA4 underlies G1 progression in vascular smooth muscle cells and that PMCA4a and PMCA4b differentially regulate specific downstream mediators.
Both Ca2+-ATPase splice variants are expressed in the testis and throughout the epididymis.
Ca(2+) homeostasis in sperm is maintained by the relative ratios of CASK-PMCA4b and CASK-JAM-A interactions
Plasma membrane calcium pump (PMCA) isoform 4 is targeted to the apical membrane by the w-splice insert from PMCA2.
Plasma membrane calcium pump (PMCA4)-neuronal nitric-oxide synthase complex regulates cardiac contractility through modulation of a compartmentalized cyclic nucleotide microdomain.
expression of Atp2b4 significantly decreased in enamel organs from Mmp20(-/-) mice. A feedback mechanism regulates ion-responsive gene expression during enamel development.
PMCA4 was found to be selectively expressed in both synaptic layers of the retina
G1/S-specific PMCA4 repression in proliferating VSMC is brought about by c-Myb and CaMK-II
PMCA4 represents a novel regulator of vascular tone
PMCA4 has a pivotal role in the regulation of sperm function and intracellular Ca(2+) levels
Switch of PMCA4 splice variants in bovine epididymis results in altered isoform expression during functional sperm maturation.
results indicate possible functional compartmentalization of PMCA in bull sperm membranes and point to a presumptive, interaction partner of Ca(2+)-ATPase and PDC-109.
thermodynamic analysis of mitochondrial F1 ATPase
lipid rafts may contribute to the interaction of PMCA4 with proteins involved in Ca2+ signaling at discrete functional positions on the synaptic nerve terminals
The protein encoded by this gene belongs to the family of P-type primary ion transport ATPases characterized by the formation of an aspartyl phosphate intermediate during the reaction cycle. These enzymes remove bivalent calcium ions from eukaryotic cells against very large concentration gradients and play a critical role in intracellular calcium homeostasis. The mammalian plasma membrane calcium ATPase isoforms are encoded by at least four separate genes and the diversity of these enzymes is further increased by alternative splicing of transcripts. The expression of different isoforms and splice variants is regulated in a developmental, tissue- and cell type-specific manner, suggesting that these pumps are functionally adapted to the physiological needs of particular cells and tissues. This gene encodes the plasma membrane calcium ATPase isoform 4. Alternatively spliced transcript variants encoding different isoforms have been identified.
matrix-remodeling-associated protein 1
, plasma membrane calcium-transporting ATPase 4
, sarcolemmal calcium pump
, ATPase, Ca++ transporting, plasma membrane 3
, plasma membrane calcium ATPase 3
, plasma membrane calcium ATPase
, plasma membrane calcium ATPase 4
, ATPase, Ca++ transporting, plasma membrane 4
, ATPase, Ca++ transporting, plasma membrane 4 ATP synthase, H+ transporting, mitochondrial F1
, plasma membrane Ca2+-ATPases 4
, plasma membrane calcium pump
, plasma membrane calcium-transporting ATPase 4-like
, ATPase, Ca++ transporting, plasma membrane 4 tv2