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SARS-CoV-2 Spike S1 Protéines

(SARS-CoV-2 Spike S1)
attaches the virion to the cell membrane by interacting with host receptor, initiating the infection (By similarity). Binding to human ACE2 receptor and internalization of the virus into the endosomes of the host cell induces conformational changes in the Spike glycoprotein (PubMed:32142651, PubMed:32075877, PubMed:32155444). Uses also human TMPRSS2 for priming in human lung cells which is an essential step for viral entry (PubMed:32142651). Proteolysis by cathepsin CTSL may unmask the fusion peptide of S2 and activate membranes fusion within endosomes.

90 Résultats

Origine: SARS Coronavirus-2 (SARS-CoV-2) Hôte: HEK-293 Cells Recombinant >95 % as determined by SDS-PAGE. ELISA, SDS
Pubmed 1 reference
N° du produit ABIN6952630
 
Origine: SARS Coronavirus-2 (SARS-CoV-2) Hôte: HEK-293 Cells Recombinant > 90 % as determined by SDS-PAGE. > 90 % as determined by SEC-MALS.
Pubmed 3 références
N° du produit ABIN6952457
 
Origine: SARS Coronavirus (SARS-CoV) Hôte: HEK-293 Cells Recombinant > 95 % as determined by Tris-Bis PAGE,> 95 % as determined by HPLC
N° du produit ABIN7275550
 
Origine: SARS Coronavirus-2 (SARS-CoV-2) Hôte: HEK-293 Cells Recombinant > 95 % as determined by Tris-Bis PAGE,> 95 % as determined by HPLC
N° du produit ABIN7274409
 
Origine: SARS Coronavirus-2 (SARS-CoV-2) Hôte: HEK-293 Cells Recombinant > 95 % as determined by Tris-Bis PAGE,> 95 % as determined by HPLC
N° du produit ABIN7274872
 
Origine: SARS Coronavirus-2 (SARS-CoV-2) Hôte: HEK-293 Cells Recombinant > 95 % as determined by Tris-Bis PAGE,> 95 % as determined by HPLC
N° du produit ABIN7274392
 
Origine: SARS Coronavirus-2 (SARS-CoV-2) Hôte: HEK-293 Cells Recombinant > 95 % as determined by Tris-Bis PAGE,> 95 % as determined by HPLC
N° du produit ABIN7274396
 
Origine: SARS Coronavirus-2 (SARS-CoV-2) Hôte: HEK-293 Cells Recombinant > 95 % as determined by Tris-Bis PAGE
N° du produit ABIN7274390
 
Origine: SARS Coronavirus-2 (SARS-CoV-2) Hôte: HEK-293 Cells Recombinant > 95 % by SDS-PAGE. SDS, Func Active
N° du produit ABIN6952742
 
Origine: SARS Coronavirus-2 (SARS-CoV-2) Hôte: HEK-293 Cells Recombinant > 90 % by SDS-PAGE. SDS, Func Active
N° du produit ABIN6952732
 
Origine: SARS Coronavirus-2 (SARS-CoV-2) Hôte: HEK-293 Cells Recombinant Greater than 90 % as determined by SDS-PAGE. WB, ELISA Active
N° du produit ABIN6952776
 
Origine: SARS Coronavirus-2 (SARS-CoV-2) Hôte: HEK-293 Cells Recombinant The purity of the protein is greater than 95 % as determined by SDS-PAGE and Coomassie blue staining. WB
N° du produit ABIN6961173
 
Origine: SARS Coronavirus-2 (SARS-CoV-2) Hôte: HEK-293 Cells Recombinant The purity of the protein is greater than 95 % as determined by SDS-PAGE and Coomassie blue staining. WB
N° du produit ABIN6961172
 
Origine: SARS Coronavirus (SARS-CoV) Hôte: HEK-293 Cells Recombinant > 95 % as determined by Tris-Bis PAGE,> 95 % as determined by HPLC
N° du produit ABIN7275551
 
Origine: SARS Coronavirus-2 (SARS-CoV-2) Hôte: HEK-293 Cells Recombinant > 95 % as determined by Tris-Bis PAGE,> 95 % as determined by HPLC
N° du produit ABIN7274410
 
Origine: SARS Coronavirus (SARS-CoV) Hôte: HEK-293 Cells Recombinant > 95 % as determined by Tris-Bis PAGE,> 95 % as determined by HPLC
N° du produit ABIN7275553
 
Origine: SARS Coronavirus-2 (SARS-CoV-2) Hôte: HEK-293 Cells Recombinant >95 % by SDS-PAGE,> 95 % by HPLC SDS, Func Active
N° du produit ABIN6952735
 
Origine: SARS Coronavirus-2 (SARS-CoV-2), SARS CoV-2 Beta Hôte: HEK-293 Cells Recombinant >90 % as determined by SDS-PAGE. Active
N° du produit ABIN6992377
 
Origine: SARS Coronavirus-2 (SARS-CoV-2), SARS CoV-2 Gamma Hôte: HEK-293 Cells Recombinant >90 % as determined by SDS-PAGE. Active
N° du produit ABIN6992361
 
Origine: SARS Coronavirus-2 (SARS-CoV-2), SARS CoV-2 Alpha Hôte: HEK-293 Cells Recombinant >95 % as determined by SDS-PAGE. Active
N° du produit ABIN6992403
 
  • Type Protein
    • Protein
  • Application
    • ELISA
    • SDS-PAGE (SDS)
    • Western Blotting (WB)
    • Functional Studies (Func)
    • Lateral Flow (LF)
    • Control (Ct)
    • Enzyme Immunoassay (EIA)
    • Immunogen (Imm)
    • Positive Control (PC)
  • Réactivité
    • SARS Coronavirus-2 (SARS-CoV-2)
    • SARS Coronavirus (SARS-CoV)
    • SARS CoV-2 Beta
    • SARS CoV-2 Omicron
    • SARS CoV-2 Delta
    • Coronavirus (CoV)
    • SARS CoV-2 Alpha
    • SARS CoV-2 Gamma
    • SARS CoV-2 Kappa
  • Cité dans publications
  • Images disponible
  • Sans conservateur uniquement
  • Carrier free only
  • Hote
    • HEK-293 Cells
    • Insect Cells
    • Escherichia coli (E. coli)
    • Baculovirus infected Insect Cells
    • CHO Cells
    • Human Cells
    • Tobacco (Nicotiana benthamiana)
  • Epitope
    • RBD
    • AA 16-685
    • D614G
    • N-Term
    • B.1.351 - beta
    • AA 1-674
    • AA 319-541
    • B.1.1.529 - Omicron
    • B.1.617.2 - delta
    • N501Y
    • BA.4 - Omicron
    • BA.5 - Omicron
    • Extracellular Domain
    • P.1 - gamma
    • AA 1-305
    • AA 1-681
    • AA 1-685
    • AA 14-683
    • AA 14-685
    • AA 315-535
    • AA 330-530
    • Asp614Gly
    • B.1.1.7 - alpha
    • B.1.617.1 - kappa
    • B.1.640
    • BA.2 - Omicron
    • BA.2.12.1 - Omicron
    • BA.2.75 - Omicron
    • C-Term
    • C.37 - Lambda
    • Deltacron
    • E484K
    • G476S
    • K417N
    • NTD
    • V367F
    • V483A
    • W436R
  • Conjugué
    • His tag
    • Fc Tag
    • mFc Tag
    • His tag,AVI tag,Biotin
    • His-Avi Tag
    • Fc-Avi Tag
    • His-Avi Tag,Biotin
    • Fc-Avi Tag,Biotin
    • Inconjugué
    • Biotin
    • Biotin,His-Avi Tag
    • Fc-His Tag
    • GST tag,His tag
    • His tag,Biotin
    • His tag,Fc Tag
    • His tag,SEKDEL Tag
    • His-DYKDDDDK Tag
    • sFc-Tag
  • Type Proteine
    • Recombinant
  • Format
    • Lyophilized
    • Liquid
  • Activité biologique
    • Biologically Active
    • Biologically Inactive
  • Supplier
    • antibodies-online
    • ACROBiosystems
    • ProSci
    • RayBiotech

Dernières publications pour nos SARS-CoV-2 Spike S1 Protéines

Erickson, Logsdon, Rhea, Hansen, Holden, Banks, Smith, German, Farr, Morley, Weaver, Hirsch, Kovac, Kontsekova, Baumann, Omer, Raber: "Blood-brain barrier penetration of non-replicating SARS-CoV-2 and S1 variants of concern induce neuroinflammation which is accentuated in a mouse model of Alzheimer's disease." dans: Brain, behavior, and immunity, Vol. 109, pp. 251-268, (2023) (PubMed).

Fan, Parr, Kang, Gupta: "Point-of-care (POC) SARS-CoV-2 antigen detection using functionalized aerosol jet-printed organic electrochemical transistors (OECTs)." dans: Nanoscale, Vol. 15, Issue 11, pp. 5476-5485, (2023) (PubMed).

Kaneko, Satta, Komuro, Muthukrishnan, Kakarla, Guo, An, Elahi, Kornblum, Liebeskind, Hsiai, Hinman: "Flow-Mediated Susceptibility and Molecular Response of Cerebral Endothelia to SARS-CoV-2 Infection." dans: Stroke, Vol. 52, Issue 1, pp. 260-270, (2021) (PubMed).

Sasisekharan, Pentakota, Jayaraman, Tharakaraman, Wogan, Narayanasami: "Orthogonal immunoassays for IgG antibodies to SARS-CoV-2 antigens reveal that immune response lasts beyond 4 mo post illness onset." dans: Proceedings of the National Academy of Sciences of the United States of America, Vol. 118, Issue 5, (2021) (PubMed).

Dogan, Kozhaya, Placek, Gunter, Yigit, Hardy, Plassmeyer, Coatney, Lillard, Bukhari, Kleinberg, Hayes, Arditi, Klapper, Merin, Liang, Gupta, Alpan, Unutmaz: "SARS-CoV-2 specific antibody and neutralization assays reveal the wide range of the humoral immune response to virus." dans: Communications biology, Vol. 4, Issue 1, pp. 129, (2021) (PubMed).

Narang, James, Balmer, Wilson: "Protein Footprinting, Conformational Dynamics, and Core Interface-Adjacent Neutralization "Hotspots" in the SARS-CoV-2 Spike Protein Receptor Binding Domain/Human ACE2 Interaction." dans: Journal of the American Society for Mass Spectrometry, (2021) (PubMed).

Fiedler, Piziorska, Denninger, Morgunov, Ilsley, Malik, Schneider, Devenish, Meisl, Kosmoliaptsis, Aguzzi, Fiegler, Knowles: "Antibody Affinity Governs the Inhibition of SARS-CoV-2 Spike/ACE2 Binding in Patient Serum." dans: ACS infectious diseases, (2021) (PubMed).

Lucas, Klein, Sundaram, Liu, Wong, Silva, Mao, Oh, Mohanty, Huang, Tokuyama, Lu, Venkataraman, Park, Israelow, Vogels, Muenker, Chang, Casanovas-Massana, Moore, Zell, Fournier, Wyllie, Campbell, Lee et al.: "Delayed production of neutralizing antibodies correlates with fatal COVID-19. ..." dans: Nature medicine, (2021) (PubMed).

Song, Bartley, Chow, Ngo, Jiang, Zamecnik, Dandekar, Loudermilk, Dai, Liu, Sunshine, Liu, Wu, Hawes, Alvarenga, Huynh, McAlpine, Rahman, Geng, Chiarella, Goldman-Israelow, Vogels, Grubaugh et al.: "Divergent and self-reactive immune responses in the CNS of COVID-19 patients with neurological symptoms. ..." dans: Cell reports. Medicine, pp. 100288, (2021) (PubMed).

Guo, Huang, Zhang, Yao, Zhou, Shen, Shen, Li, Li, Zhang, Chen, Chen, Wu, Fu, Zeng, Feng, Pi, Wang, Zhou, Lu, Li, Fang, Lu, Hu, Wang, Zhang, Gao, Adrian, Wang, Yu, Peng, Gabibov, Min, Wang, Huang et al.: "A SARS-CoV-2 neutralizing antibody with extensive Spike binding coverage and modified for optimal therapeutic outcomes. ..." dans: Nature communications, Vol. 12, Issue 1, pp. 2623, (2021) (PubMed).

Pseudonymes pour SARS-CoV-2 Spike S1 Protéines

Surface Glycoprotein (S) Protéines
E2 Protéines
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