Lapin anti-Humain IgM (Chain mu) Anticorps

N° du produit ABIN952869

Détail du produit

Antigène: IgM

Épitope: Chain mu

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Application: Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Attributs du produit: Anti-IgM antibody reacts with surface immunoglobulin IgM mu chains. IgM is one of the predominant surface immunoglobulins on B-lymphocytes. This antibody is useful when identifying lymphomas, plasmacytomas, and B-cell lineage derived Hodgkin's lymphomas. Due to the restricted expression of heavy and light chains in these diseases, demonstration of B-cell lymphomas is possible with clonal gene rearrangement studies.

Purification: Purified

Immunogène: Purified IgM.

Information d'application

Indications d'application: Optimal working dilutions should be determined experimentally by the investigator.

Restrictions: For Research Use only

Stockage

Format: Liquid

Stock: 4 °C

Stockage commentaire: Store the antibody undiluted at 2-8 °C.

Détail du antigène

Antigène: IgM

Abstract: IgM Produits

Classe de substances: Antibody

Sujet: IgM normally constitutes about 10 % of serum immunoglobulins. IgM antibody is prominent in early immune responses to most antigens and is largely confined to plasma due to it's large size. Monomeric IgM is expressed as a membrane bound antibody on the surface of B cells and as a pentamer when secreted by plasma cells. Due to it's high valency IgM is more efficient than other isotypes is binding antigens with repeating epitopes (virus particles and red blood cells) and is more efficient than IgG in activiating the complement pathway. The gene for the mu constant region contains four domains separated by short intervening sequences. IgM measurement yields information about the body's immediate resistance and response to infection as well as information related to specific diseases. Decreased levels are associated with immune deficiency states, hereditary deficiencies, and myeloma. Increased levels can be associated with Waldenstrom's macroglobulinemia, chronic infection and hepatocellular disease.Synonyms: Human Immunoglobulin M