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anti-Rat (Rattus) MAP2K2 Anticorps:
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Chicken Monoclonal MAP2K2 Primary Antibody pour IHC (f), IF - ABIN967846
Crews, Alessandrini, Erikson: The primary structure of MEK, a protein kinase that phosphorylates the ERK gene product. dans Science (New York, N.Y.) 1992
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Human Polyclonal MAP2K2 Primary Antibody pour IF, WB - ABIN1882178
Burroughs, Oh, Barrett, DiAugustine et al.: Phosphatidylinositol 3-kinase and mek1/2 are necessary for insulin-like growth factor-I-induced vascular endothelial growth factor synthesis in prostate epithelial cells: a role for hypoxia-inducible ... dans Molecular cancer research : MCR 2003
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Human Polyclonal MAP2K2 Primary Antibody pour IHC (p), WB - ABIN1881526
Tran, Maurer, Nagamine: Stabilization of urokinase and urokinase receptor mRNAs by HuR is linked to its cytoplasmic accumulation induced by activated mitogen-activated protein kinase-activated protein kinase 2. dans Molecular and cellular biology 2003
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Chicken Monoclonal MAP2K2 Primary Antibody pour IHC (f), IF - ABIN967845
Downey, Butler, Tapper, Fialkow, Saltiel, Rubin, Grinstein: Importance of MEK in neutrophil microbicidal responsiveness. dans Journal of immunology (Baltimore, Md. : 1950) 1998
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There are no other biomarkers correlated with treatment responses following MEK1 (Montrer MAP2K1 Anticorps)/2 inhibition.
MEK2 was essential for the phosphorylation of MKK3 (Montrer MAP2K3 Anticorps)/MKK6 (Montrer MAP2K6 Anticorps) and p38 MAPK (Montrer MAPK14 Anticorps) that directly impacted on cyclin D1 (Montrer CCND1 Anticorps) expression.
High MEK2 expression is associated with inflammation.
there were significant decreases in intercellular adhesion molecules 1 (ICAM1 (Montrer ICAM1 Anticorps)), ezrin (EZR (Montrer EZR Anticorps)), mitogen-activated protein kinase kinase 2 (MAP2K2), and nitric oxide synthase (Montrer NOS Anticorps) 3 (NOS3 (Montrer NANOS3 Anticorps)) gene expressions in metabolic syndrome patients.
The patient showed a paternally inherited 16p13.11 microduplication and a de novo 19p13.3 microdeletion involving the mitogen-activated protein kinase kinase 2 gene (MAP2K2), in which mutations cause the cardio-facio-cutaneous (CFC (Montrer PTPN11 Anticorps)) syndrome
Data show that mitogen-activated protein kinase (Montrer MAPK1 Anticorps) kinases MEK1 (Montrer MAP2K1 Anticorps)/2 inhibitor pimasertib (MEKI) sensitized the cells to apoptosis through its ability to promote a G1 cell cycle arrest.
the purpose of this paper was to investigate MAPK (Montrer MAPK1 Anticorps) downstream signalling molecules in Natural killer cell phenotypes from Chronic Fatigue Syndrome/Myalgic Encephalomyelitis patients.
at clinically relevant concentrations, cDDP binds to and inhibits MEK1 (Montrer MAP2K1 Anticorps)/2 and both the binding and inhibitory activity are related to its interaction with Cu bound to MEK1 (Montrer MAP2K1 Anticorps)/2
Endocytosis separates EGF (Montrer EGF Anticorps) receptors from endogenous fluorescently labeled HRas (Montrer HRAS Anticorps) and diminishes receptor signaling to MAP kinases in endosomes.
MEK1 (Montrer MAP2K1 Anticorps) levels are upregulated at transcriptional level whereas MEK2 levels are downregulated at posttranslational level.
data suggest that, although short-term suppression of Mek1 (Montrer MAP2K1 Anticorps)/2 in ES cells helps to maintain an inner cell mass-like epigenetic state, prolonged suppression results in irreversible changes that compromise their developmental potential
Erk5 (Montrer MAPK7 Anticorps) MAP kinase (Montrer MAPK1 Anticorps) is activated in response to PDGF (Montrer PDGFA Anticorps)-BB in the smooth muscle cell line MOVAS in a manner dependent on Mekk2 (Montrer MAP3K2 Anticorps), Mek1 (Montrer MAP2K1 Anticorps)/2, Mek5 (Montrer MAP2K5 Anticorps), PI3-kinase (Montrer PIK3CA Anticorps) and protein kinase C (PKC (Montrer PKC Anticorps)).
fluid shear stress induces autocrine TGF-beta (Montrer TGFB1 Anticorps)/ALK5 (Montrer TGFBR1 Anticorps)-induced target gene expression in renal epithelial cells, which is partially restrained by MEK1 (Montrer MAP2K1 Anticorps)/2-mediated signaling.
FGF2 (Montrer FGF2 Anticorps) is an extracellular inducer of COUP-TFII (Montrer NR2F2 Anticorps) expression and may suppress the osteogenic potential of mesenchymal cells by inducing COUP-TFII (Montrer NR2F2 Anticorps) expression prior to the onset of osteogenic differentiation
REDD1 (Montrer DDIT4 Anticorps) is required for normal insulin (Montrer INS Anticorps)-stimulated signaling, and a subtle balance exists between MEK1 (Montrer MAP2K1 Anticorps)/2, REDD1 (Montrer DDIT4 Anticorps), and mTOR (Montrer FRAP1 Anticorps)
MEK1 (Montrer MAP2K1 Anticorps) and MEK2 can substitute for each other but a minimum amount of MEK (Montrer MDK Anticorps) is critical for placenta development and embryo survival
MK2 (Montrer KCNA2 Anticorps)/3 cascade plays a strategic role in controlling synaptic plasticity and cognition.
MK2 (Montrer KCNA2 Anticorps) attenuates dendritic cell-mediated Th1 (Montrer HAND1 Anticorps) differentiation and autoimmune encephalomyelitis.
analysis of p38 (Montrer CRK Anticorps)-MK2 (Montrer KCNA2 Anticorps)-activated Rsk (Montrer RPS6KA1 Anticorps) signaling in toll (Montrer TLR4 Anticorps)-like receptor-stimulated dendritic cells
both MEK1 (Montrer MAP2K1 Anticorps) and MEK2 have crucial roles in the integration of mesenchymal and epithelial signals essential for the development of the entire respiratory tract
the AtMKK2-AtMPK10 (Montrer MAPK10 Anticorps) MAPK (Montrer MAPK1 Anticorps) module regulates leaf venation complexity by altering polar auxin transport efficiency
Treatment of Arabidopsis with a membrane rigidifier, DMSO, causes MPK4 (Montrer MAPK4 Anticorps) activation concomitantly with MEKK1 (Montrer MAP3K1 Anticorps) and MKK2 phosphorylation.
Ca(2 (Montrer CA2 Anticorps)+) signaling occurred upstream of the MEKK1 (Montrer MAP3K1 Anticorps)-MKK2 pathway. MEKK1 (Montrer MAP3K1 Anticorps) was phosphorylated by calcium/calmodulin-regulated receptor-like kinase (CRLK1), which suggested that CRLK1 is one of candidates located upstream of MEKK1 (Montrer MAP3K1 Anticorps).
Data indicate that MEKK2 (Montrer MAP3K2 Anticorps) is required for the mekk1 (Montrer MAP3K1 Anticorps), mkk1 (Montrer MAP2K1 Anticorps) mkk2, and mpk4 (Montrer MAPK4 Anticorps) autoimmune phenotypes.
Data suggest that the MEKK1 (Montrer MAP3K1 Anticorps)-MKK1 (Montrer MAP2K1 Anticorps)/MKK2-MPK4 (Montrer MAPK4 Anticorps) kinase cascade negatively regulates MEKK2 (Montrer MAP3K2 Anticorps) and activation of MEKK2 (Montrer MAP3K2 Anticorps) triggers SUMM2-mediated immune responses.
Data indicate that MKK2 plays a role in abiotic stress tolerance and plant disease resistance.
double loss-of-function mutant (mkk1 (Montrer MAP2K1 Anticorps)/2) of MKK1 (Montrer MAP2K1 Anticorps) and MKK2 is shown to have marked phenotypes in development and disease
Activation of MPK4 (Montrer MAPK4 Anticorps) by flg22 is impaired in the mkk1 (Montrer MAP2K1 Anticorps) mkk2 double mutants, suggesting that MKK1 (Montrer MAP2K1 Anticorps) and MKK2 function together with MPK4 (Montrer MAPK4 Anticorps) and MEKK1 (Montrer MAP3K1 Anticorps) in a MAP kinase (Montrer MAPK1 Anticorps) cascade to negatively regulate innate immune responses in plants.
The protein encoded by this gene is a dual specificity protein kinase that belongs to the MAP kinase kinase family. This kinase is known to play a critical role in mitogen growth factor signal transduction. It phosphorylates and thus activates MAPK1/ERK2 and MAPK2/ERK3. The activation of this kinase itself is dependent on the Ser/Thr phosphorylation by MAP kinase kinase kinases. Mutations in this gene cause cardiofaciocutaneous syndrome (CFC syndrome), a disease characterized by heart defects, mental retardation, and distinctive facial features similar to those found in Noonan syndrome. The inhibition or degradation of this kinase is also found to be involved in the pathogenesis of Yersinia and anthrax. A pseudogene, which is located on chromosome 7, has been identified for this gene.
ERK activator kinase 2
, MAP kinase kinase 2
, MAPK/ERK kinase 2
, MAPKK 2
, MEK 2
, dual specificity mitogen-activated protein kinase kinase 2
, mitogen-activated protein kinase kinase 2, p45
, MAP kinase/Erk kinase
, mitogen activated protein kinase kinase 2
, protein kinase, mitogen activated, kinase 2, p45
, dual specificity mitogen activated protein kinase kinase 2
, mitogen-activated protein kinase kinase type 2