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Study conclude that the splice variants of RON lacking exon 11 and exons 11-13 were detected in several lung cancer cell lines. Novel variant formed by skipping exons 11-13, the sequence of which code for transmembrane region, is predicted to code for a truncated isoform that may be secreted out.
RONDelta165E2 variant promoted tumor progression while activating the PI3K/AKT pathway via PTEN phosphorylation in colorectal carcinoma.
These findings indicate that RON and c-Met facilitate metastasis through ERK1/2 signaling and that targeting RON and c-Met with foretinib may be an attractive therapeutic option for suppressing Prostate cancer metastasis
Forkhead box C1 (Montrer FOXC1 Protéines) protein (FOXC1 (Montrer FOXC1 Protéines)) promotes melanoma cell function by regulating macrophage stimulating 1 receptor (MST1R) and activating MST1R/PI3K (Montrer PIK3CA Protéines)/AKT (Montrer AKT1 Protéines) pathway.
RON has a role in cancer-induced bone destruction and osteoporosis
RON isoforms may comprise half of total RON transcript in human pancreatic cancer and their expression is regulated at least in part by promoter hypermethylation.
High RON expression is associated with castration resistant prostate cancer.
hnRNP A1 (Montrer HNRNPA1 Protéines) directly binds to the 5' untranslated region of the RON mRNA and activates its translation through G-quadruplex RNA secondary structures
Findings indicate a role of the RON tyrosine kinase receptor (Montrer NTRK1 Protéines) in pancreatic cancer and suggest RON as a potential therapeutic target.
High expression of RON is associated with drug resistance in bladder cancer.
this study shows that Ron is expressed in a subpopulation of macrophages during chronic inflammation induced by obesity that exhibit a repair phenotype as determined by the expression of arginase 1 (Montrer ARG1 Protéines)
Report Ron receptor-dependent gene regulation of inflammatory/anti-inflammatory gene expression in Kupffer cells during endotoxemia.
Ron knockdown further sensitized breast cancer cells to the growth inhibitory effects of vitamin D3, while constitutive activation of beta-catenin (Montrer CTNNB1 Protéines) reverted the effects of vitamin D3.
Studies demonstrate that DEK (Montrer DEK Protéines) overexpression, due in part to Ron receptor activation, drives breast cancer progression through the induction of Wnt (Montrer WNT2 Protéines)/beta-catenin (Montrer CTNNB1 Protéines) signaling.
A previously unknown function for the Ron receptor in mediating High Fat Diet-induced obesity and metabolic dysregulation.
important functional roles for Ron in inflammatory bowel diseases by regulating healing of the colonic epithelium and by controlling cytokine secretion
DC-STAMP, Siglec-15 (Montrer SIGLEC15 Protéines), Tspan7 (Montrer TSPAN7 Protéines) and Mst1r expression was downregulated by docosahexaenoic acid, but not eicosapentaenoic acid during osteoclastogenesis in vitro.
Stem cell-derived tyrosine kinase plays a role in regulating macrophage recruitment and activation in the liver following acetaminophen administration and in hepatotoxicity.
studies show a critical role for the Ron receptor in the tumor microenvironment, whereby Ron loss in tumor-associated macrophages inhibits prostate cancer cell growth, at least in part, by derepressing the activity of CD8 (Montrer CD8A Protéines)(+) T cells
This gene encodes a cell surface receptor for macrophage-stimulating protein (MSP) with tyrosine kinase activity. The mature form of this protein is a heterodimer of disulfide-linked alpha and beta subunits, generated by proteolytic cleavage of a single-chain precursor. The beta subunit undergoes tyrosine phosphorylation upon stimulation by MSP. This protein is expressed on the ciliated epithelia of the mucociliary transport apparatus of the lung, and together with MSP, thought to be involved in host defense. Alternatively spliced transcript variants encoding different isoforms with different structural and biochemical properties have been described (PMID:8816464).
, MST1R variant RON30
, MST1R variant RON62
, PTK8 protein tyrosine kinase 8
, RON variant 21
, RON variant E2E3
, c-met-related tyrosine kinase
, macrophage-stimulating protein receptor
, soluble RON variant 1
, soluble RON variant 2
, soluble RON variant 3
, soluble RON variant 4
, friend virus susceptibility 2
, macrophage-stimulating protein receptor precursor (MSP receptor) (p185-Ron) (Stem cell-derived tyrosine kinase)
, receptor protein tyrosine kinase, c-met-related
, stem cell-derived tyrosine kinase
, protein tyrosine kinase 8
, tyrosine kinase receptor ron