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anti-Mouse (Murine) Neuregulin 1 Anticorps:
anti-Human Neuregulin 1 Anticorps:
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Human Polyclonal Neuregulin 1 Primary Antibody pour WB - ABIN516692
Nordqvist, Kårehed, Hambiliki, Wånggren, Stavreus-Evers, Akerud: The presence of histidine-rich glycoprotein in the female reproductive tract and in embryos. dans Reproductive sciences (Thousand Oaks, Calif.) 2010
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Human Polyclonal Neuregulin 1 Primary Antibody pour FACS, IHC (p) - ABIN390160
Ritch, Carroll, Sontheimer: Neuregulin-1 enhances motility and migration of human astrocytic glioma cells. dans The Journal of biological chemistry 2003
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Human Polyclonal Neuregulin 1 Primary Antibody pour WB - ABIN3043580
Wang, Zhou, Ding, Zhu, Jiang, Fu, Wang, Hu, Ge: Qiliqiangxin improves cardiac function and attenuates cardiac remodeling in rats with experimental myocardial infarction. dans International journal of clinical and experimental pathology 2015
NOTCH1 (Montrer NOTCH1 Anticorps) signalling promotes extracellular matrix (ECM (Montrer MMRN1 Anticorps)) degradation during the formation of endocardial projections that are critical for individualization of trabecular units, whereas NRG1 promotes myocardial ECM (Montrer MMRN1 Anticorps) synthesis, which is necessary for trabecular rearrangement and growth.
Overexpression of neuregulin 1 alpha suppressed Nuclear forkhead box protein O1 (FoxO1 (Montrer FOXO1 Anticorps)) and its downstream targets, PEPCK (Montrer PEPCK Anticorps) and G6Pase (Montrer G6PC Anticorps) in liver and isolated hepatocytes.
Study shows that within endoplasmic reticulum-related subsurface cistern, sigma-1 receptors, Kv2.1 (Montrer KCNB1 Anticorps) and neuregulin-1 are clustered in highly specific, non-overlapping, microdomains, whereas ErbB2 (Montrer ERBB2 Anticorps) and ErbB4 (Montrer ERBB4 Anticorps) are present in the adjacent presynaptic compartment. This organization may define highly ordered and spatially restricted sites for different signal-transduction pathways.
Result suggest the potential for a paracrine signalling network whereby basal cells secrete neuregulin 1 (Nrg1), which acts on luminal cells via Erbb3 (Montrer ERBB3 Anticorps) and Erbb4 (Montrer ERBB4 Anticorps) receptors.
We show here that cleavage-stimuli-induced specific ICD-modifications cause structural substrate changes that enhance ectodomain sensitivity of neuregulin-1 (NRG1; epidermal-growth-factor (Montrer EGF Anticorps)) or CD44 (Montrer CD44 Anticorps) (receptor-tyrosine-kinase (Montrer ERBB3 Anticorps) (RTK) co-receptor) to chymotrypsin/trypsin or soluble ADAM.
Study found that the expression level of the neuregulin-1 (NRG1) protein was increased in the medial prefrontal cortex of fear-conditioned mice and manipulation of NRG1 activity in the prelimbic cortex affected fear-conditioning behaviors.
The manipulation of NRG1/ErbB4 (Montrer ERBB4 Anticorps) signaling in the present study revealed that NRG1/ErbB4 (Montrer ERBB4 Anticorps) activity in the hippocampus is critical for learning and memory.
Nrg1-I intramuscular injection enhanced muscle reinnervation by collateral sprouting
These results collectively suggest that sustained activation of Wnt (Montrer WNT2 Anticorps)/beta-catenin (Montrer CTNNB1 Anticorps) signaling in endothelial cells might be a cause of heart failure through suppressing neuregulin-ErbB (Montrer EGFR Anticorps) signaling.
These results suggest that the neuropsin (Montrer KLK8 Anticorps)-NRG1 signaling system has a role in pathological processes underlying temporal lobe epilepsy by regulating the activity of parvalbumin (Montrer PVALB Anticorps)-expressing interneurons, and that neuropsin (Montrer KLK8 Anticorps) regulates E/I balance and gamma oscillations through NRG1-ErbB4 (Montrer ERBB4 Anticorps) signaling toward parvalbumin (Montrer PVALB Anticorps)-expressing interneurons.
COMT (Montrer COMT Anticorps)-GG and NRG1-AA genotypes aid the transcranial direct current stimulation-induced improvement in auditory verbal hallucinations in schizophrenia patients.
The neuregulin1 was observed to be cleaved, adding to the 3 known NS3/4A cleavage targets. It showed that NS3/4A triggers an increase in neuregulin1 mRNA levels in HCV infected cells.
These results support the association between genetic variation of RET (Montrer RET Anticorps) and NRG1 and susceptibility to Hirschsprung disease in the Chinese population.
Results found that NRG1, a potential prognostic marker is highly expressed in papillary thyroid cancer (PTC (Montrer F9 Anticorps)). Also, further data demonstrate that NRG1 activates the antioxidant pathway by upregulating the expression of antioxidant enzymes through NRF2 (Montrer GABPA Anticorps), thus modulating redox homeostasis in PTC (Montrer F9 Anticorps).
Mesenchymal stem cell-drived paclitaxel resistance in ErbB2/ErbB3-coexpressing breast cancer cells could be attributed to upregulation of Survivin via paracrine effect of NRG-1/ErbB3/PI-3K/Akt signaling, as either specific knockdown expression of ErbB3, or blocking of downstream PI-3K/Akt signaling, or specific inhibition of Survivin can completely reverse this effect.
The data suggest a role for transcriptional regulation of NRG1 in the predisposition to papillary thyroid carcinoma.
NRG1rs3924999 and NRG1 rs6994992 are associated with change of temperament scores in a clinical sample of subjects with major depression (MDD), who received selective serotonin reuptake inhibitor treatment.
NRG1 is a potential prognostic and therapeutic biomarker in gastric cancer patients
Study found that the protein levels of NRG1 and ErbB4 (Montrer ERBB4 Anticorps) were significantly increased in the temporal cortex of patients with symptomatic epilepsy. Also, NRG1-ErbB4 (Montrer ERBB4 Anticorps) signaling suppresses GluN2B (Montrer GRIN2B Anticorps) phosphorylation by Src (Montrer SRC Anticorps) inhibition. GluN2B (Montrer GRIN2B Anticorps) is closely related to synaptic activity and its regulation by the NRG1-ErbB4 (Montrer ERBB4 Anticorps)-Src (Montrer SRC Anticorps) signaling axis highlights the importance of NRG1-ErbB4 (Montrer ERBB4 Anticorps) signaling in symptomatic epilepsy pathology.
Levels of NRG1 type III expression in peripheral blood mononuclear cells were positively correlated with impairments in social interaction in children with autism spectrum disorder.
Data suggest that epidermal growth factor receptor (Montrer EGFR Anticorps) B [ErbB (Montrer EGFR Anticorps)] isoforms and their ligands (epidermal growth factor (Montrer EGF Anticorps) [EGF (Montrer EGF Anticorps)], amphiregulin (Montrer AREG Anticorps) [AREG (Montrer AREG Anticorps)], and neuregulin-1 [NRG1]) are expressed in uteroplacental tissues in mid- and late-phases of pregnancy.
Cloning of a novel isoform of NRG1 (IgNRG1beta2) containing an immunoglobulin-like domain which is probably essential for efficient interaction with ErbB (Montrer EGFR Anticorps) receptors.
The present research focused on morphological distribution of Nrg1 and its receptors, ErbB2 (Montrer ERBB2 Anticorps) and ErbB4 (Montrer ERBB4 Anticorps), in main gastrointestinal tissues of the non-human primate rhesus monkey.
we observed the activation of Notch (Montrer NOTCH1 Anticorps) signaling in cardiomyocytes adjacent to those undergoing apical constriction, and we showed that this activation is positively regulated by Neuregulin signaling.
these results suggest that Nrg1 is not the primary effector of trabeculation and/or that other EGF (Montrer EGF Anticorps)-like ligand(s) activates the ErbB2 (Montrer ERBB2 Anticorps)/ErbB4 (Montrer ERBB4 Anticorps) pathway, either through functioning as the primary ligand or acting in a redundant manner. Overall, our work provides an example of cross-species differences in EGF (Montrer EGF Anticorps) family member requirements for an evolutionary conserved process.
Notch1 (Montrer NOTCH1 Anticorps) activation induces expression of ephrin b2a (efnb2a (Montrer EFNB2 Anticorps)) and neuregulin 1 (nrg1) in the endocardium to promote trabeculation and forced Notch (Montrer NOTCH1 Anticorps) activation in the absence of cardiac contraction rescues efnb2a (Montrer EFNB2 Anticorps) and nrg1 expression
These findings identify Nrg1 as a potent, induced mitogen for the endogenous adult heart regeneration program.
These results demonstrate that Nrg1 type III is an essential signal that controls Schwann cell migration to ensure that these glia are present in the correct numbers and positions in developing nerves.
ErbB3 (Montrer ERBB3 Anticorps) signaling is required for normal migration of trunk, but not cranial, neural crest cells
Disc1 (Montrer DISC1 Anticorps) and nrg1 function in controlling development of oligodendrocytes and neurones from olig2 (Montrer OLIG2 Anticorps)-expressing precursor cells.
NRG1 and PI3K functionally interact with ErbB2 (Montrer ERBB2 Anticorps) and ErbB3 (Montrer ERBB3 Anticorps) during regeneration
The protein encoded by this gene was originally identified as a 44-kD glycoprotein that interacts with the NEU/ERBB2 receptor tyrosine kinase to increase its phosphorylation on tyrosine residues. This protein is a signaling protein that mediates cell-cell interactions and plays critical roles in the growth and development of multiple organ systems. It is known that an extraordinary variety of different isoforms are produced from this gene through alternative promoter usage and splicing. These isoforms are tissue-specifically expressed and differ significantly in their structure, and thereby these isoforms are classified into types I, II, III, IV, V and VI. The gene dysregulation has been linked to diseases such as cancer, schizophrenia and bipolar disorder (BPD).
, pro-neuregulin-1, membrane-bound isoform
, type I neuregulin 1
, type III neuregulin 1
, neuregulin 1
, glial growth factor
, heregulin, alpha (45kD, ERBB2 p185-activator)
, neu differentiation factor
, neuregulin 1 type IV beta 1a
, neuregulin 1 type IV beta 3
, sensory and motor neuron derived factor
, neuregulin 1 type III beta 3
, membrane-bound isoform
, neuregulin 1 alpha isoform