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anti-Human RHEB Anticorps:
anti-Mouse (Murine) RHEB Anticorps:
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Human Polyclonal RHEB Primary Antibody pour IHC, ELISA - ABIN1003087
Yamagata, Sanders, Kaufmann, Yee, Barnes, Nathans, Worley: rheb, a growth factor- and synaptic activity-regulated gene, encodes a novel Ras-related protein. dans The Journal of biological chemistry 1994
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Human Polyclonal RHEB Primary Antibody pour ELISA, WB - ABIN1003086
Yee, Worley: Rheb interacts with Raf-1 kinase and may function to integrate growth factor- and protein kinase A-dependent signals. dans Molecular and cellular biology 1997
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Human Monoclonal RHEB Primary Antibody pour ELISA, WB - ABIN519784
Menon, Dibble, Talbott, Hoxhaj, Valvezan, Takahashi, Cantley, Manning: Spatial control of the TSC complex integrates insulin and nutrient regulation of mTORC1 at the lysosome. dans Cell 2014
Human Polyclonal RHEB Primary Antibody pour WB - ABIN2476356
Kageyama, Takahashi: Pepsinogens and pepsins from gastric mucosa of Japanese Monkey. Purification and characterization. dans Journal of biochemistry 1976
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FADD (Montrer FADD Anticorps) interference down-regulated Rheb expression and repressed mTORC1 activity in breast cancer cell lines. The autophagy was induced by FADD (Montrer FADD Anticorps) deficiency in MCF7 or MDA-231 cells but rescued by recovering Rheb expression.
Describe a novel interaction between Rheb and the tumor suppressor RASSF1A. This interaction may allow coordinate upregulation of Hippo while TOR is suppressed to modulate the balance of apoptosis and autophagy in lung tumor cells.
activation of mTOR (Montrer FRAP1 Anticorps) signalling via RHEB over-expression inhibited the starvation-induced autophagy but did not affect trafficking of tf-Amyloid precursor protein (APP (Montrer APP Anticorps)). These results show tf-APP (Montrer APP Anticorps) can be used to determine how APP (Montrer APP Anticorps) is trafficked through the lysosomal system of the cell.
Data suggest DNM2 (Montrer DNM2 Anticorps)/RRAGB (Montrer RRAGB Anticorps)- (or DNM2 (Montrer DNM2 Anticorps)/RRAGC (Montrer RRAGC Anticorps)-)dependent endocytosis of extracellular amino acids (AAs (Montrer FGD1 Anticorps)) plays critical role in mTORC1 transport/activation; recruitment of mTORC1 from cytoplasm to lysosome is suppressed by DNM2 (Montrer DNM2 Anticorps) inhibition; AA deprivation appears to be main cause of mTORC1 inactivation via DNM2 (Montrer DNM2 Anticorps) inhibition. (RHEB = Ras homolog enriched in brain; DNM2 (Montrer DNM2 Anticorps) = dynamin II (Montrer DNM2 Anticorps); RRAG = Ras-related GTP binding protein (Montrer RAB10 Anticorps))
By interfering with TSC (Montrer SLC12A3 Anticorps)-Rheb complex, arginine relieves allosteric inhibition of Rheb by TSC (Montrer SLC12A3 Anticorps). Arginine cooperates with growth factor signaling which further promotes dissociation of TSC2 (Montrer TSC2 Anticorps) from lysosomes and activation of mTORC1.
Data show that Rheb/p27 (Montrer PAK2 Anticorps) axis induces autophagy-dependent cancer cell survival under stress conditions.
Mutations in the TSC2 (Montrer TSC2 Anticorps)-RHEB-mTOR (Montrer FRAP1 Anticorps) signaling axis may lead to a loss of inhibitory inputs thus conferring a survival advantage to a dividing tumor cell.
Activation of CNTF (Montrer CNTF Anticorps)/CNTFRalpha (Montrer CNTFR Anticorps) signaling pathway by hRheb(S16H) transduction of dopaminergic neurons
RGS10 (Montrer RGS10 Anticorps) could serve in a novel, and previously unknown, role by accelerating the hydrolysis of GTP (Montrer AK3 Anticorps) from Rheb in ovarian cancer cells.
In TSC2 (Montrer TSC2 Anticorps)-deficient angiomyolipoma patient cells, IRF7 (Montrer IRF7 Anticorps) is a pivotal factor in the Rheb/mTOR (Montrer FRAP1 Anticorps) pathway.
Thus, the various regulatory elements that impinge upstream of mTORC1 activation pathways are differentially required for HSC (Montrer FUT1 Anticorps) homeostasis in vivo.
Forebrain depletion of Rheb GTPase (Montrer RACGAP1 Anticorps) elicits spatial memory deficits.
Rheb is an important negative regulator of beige (Montrer LYST Anticorps) fat development and thermogenesis. Rheb is able to suppress the beiging effect through an mTORC1-independent mechanism, via PDE4D5-dependent downregulation of the cAMP-PKA signaling pathway.
Rheb and TSC2 (Montrer TSC2 Anticorps) have roles in the mechanical activation of mTOR (Montrer FRAP1 Anticorps) signaling
EAAT4 (Montrer SLC1A6 Anticorps) was downregulated due to the loss of Rheb1 in Purkinje cells; mTORC1 was downregulated and Akt (Montrer AKT1 Anticorps) was upregulated in Rheb1 cKO mice, suggesting that mTORC1 and Akt (Montrer AKT1 Anticorps) may be related to the downregulation of EAAT4 (Montrer SLC1A6 Anticorps); Rheb1 knockout decreased EAAT4 (Montrer SLC1A6 Anticorps) currents and slowed down the kinetics of AMPA (Montrer GRIA3 Anticorps) currents; Rheb1 deficiency did not affect the morphology of Purkinje cell layer and the development of Purkinje cells
Data suggest that RAS-homolog enriched in brain protein (Rheb1) promotes MLL-AF9 fusion protein initiated acute myeloid leukemia (AML) progression through target of rapamycin complex 1 (mTORC1) signaling pathway.
Rheb activation disrupts neuronal spine synapse formation via syntenin (Montrer SDCBP Anticorps) accumulation in tuberous sclerosis complex.
We conclude that in contrast to TORC1 (Montrer CRTC1 Anticorps) hyper-activity, cognitive function is not very sensitive to sustained and specific down-regulation of TORC1 (Montrer CRTC1 Anticorps) activity.
Rheb protein was mainly detected in apoptotic retinal ganglion cells following light injury.
PDK4 (Montrer PDK4 Anticorps) promotes tumorigenesis through activation of the CREB (Montrer CREB1 Anticorps)-RHEB-mTORC1 signaling cascade.
This gene is a member of the small GTPase superfamily and encodes a lipid-anchored, cell membrane protein with five repeats of the RAS-related GTP-binding region. This protein is vital in regulation of growth and cell cycle progression due to its role in the insulin/TOR/S6K signaling pathway. The protein has GTPase activity and shuttles between a GDP-bound form and a GTP-bound form, and farnesylation of the protein is required for this activity. Three pseudogenes have been mapped, two on chromosome 10 and one on chromosome 22.
Ras homolog enriched in brain
, RAS-homolog enriched in brain
, ras homolog enriched in brain
, GTP-binding protein rheb
, GTP-binding protein Rheb
, Ras homolog enriched in brain 2