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anti-Human RAB5 Anticorps:
anti-Mouse (Murine) RAB5 Anticorps:
anti-Rat (Rattus) RAB5 Anticorps:
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Human Polyclonal RAB5 Primary Antibody pour ICC, IF - ABIN266020
Sönnichsen, De Renzis, Nielsen, Rietdorf, Zerial: Distinct membrane domains on endosomes in the recycling pathway visualized by multicolor imaging of Rab4, Rab5, and Rab11. dans The Journal of cell biology 2000
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Human Monoclonal RAB5 Primary Antibody pour ELISA, WB - ABIN519585
Chamberlain, Oberg, Furber, Poland, Hawrysh, Knafelc, McBride, Anderson: Deregulation of Rab5 and Rab4 proteins in p85R274A-expressing cells alters PDGFR trafficking. dans Cellular signalling 2010
Human Monoclonal RAB5 Primary Antibody pour ICC, IP - ABIN1742214
Seipold, Damme, Prox, Rabe, Kasparek, Sedlacek, Altmeppen, Willem, Boland, Glatzel, Saftig: Tetraspanin 3: A central endocytic membrane component regulating the expression of ADAM10, presenilin and the amyloid precursor protein. dans Biochimica et biophysica acta 2016
Human Polyclonal RAB5 Primary Antibody pour IP, WB - ABIN1742215
Perlini, Botti, Fornasiero, Giannandrea, Bonanomi, Amendola, Naldini, Benfenati, Valtorta: Effects of phosphorylation and neuronal activity on the control of synapse formation by synapsin I. dans Journal of cell science 2011
Cow (Bovine) Polyclonal RAB5 Primary Antibody pour IHC, WB - ABIN2786773
Coyne, Shen, Turner, Bergelson: Coxsackievirus entry across epithelial tight junctions requires occludin and the small GTPases Rab34 and Rab5. dans Cell host & microbe 2007
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Cow (Bovine) Polyclonal RAB5 Primary Antibody pour ICC, IF - ABIN361846
Ali, Wasmeier, Lamoreux, Strom, Seabra: Multiple regions contribute to membrane targeting of Rab GTPases. dans Journal of cell science 2004
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Horse (Equine) Polyclonal RAB5 Primary Antibody pour ICC, IF - ABIN4891966
Pera, Larrea, Guardia-Laguarta, Montesinos, Velasco, Agrawal, Xu, Chan, Di Paolo, Mehler, Perumal, Macaluso, Freyberg, Acin-Perez, Enriquez, Schon, Area-Gomez: Increased localization of APP-C99 in mitochondria-associated ER membranes causes mitochondrial dysfunction in Alzheimer disease. dans The EMBO journal 2017
The authors demonstrate that RABGEF1 (Montrer RABGEF1 Anticorps), the upstream factor of the endosomal Rab GTPase (Montrer RAB6A Anticorps) cascade, is recruited to damaged mitochondria via ubiquitin binding downstream of Parkin (Montrer PARK2 Anticorps). RABGEF1 (Montrer RABGEF1 Anticorps) directs the downstream Rab (Montrer HRB Anticorps) proteins, RAB5 and RAB7A (Montrer RAB7A Anticorps), to damaged mitochondria, whose associations are further regulated by mitochondrial Rab (Montrer HRB Anticorps)-GAPs.
Low RAB5 expression is associated with glioma progression.
The expression level of EMC-6 is significantly elevated in cervical cancer, without significant correlation with Beclin1 (Montrer BECN1 Anticorps) and Rab5a.
Here the authors show that Rab5 is monoubiquitinated on K116, K140, and K165. Structural analysis combined with biochemical data revealed that interactions with downstream effectors were impeded in Rab5 monoubiquitinated at K140, whereas GDP release and GTP (Montrer AK3 Anticorps) loading activities were altered in Rab5 monoubiquitinated at K165.
Rab5a is overexpressed in oral cancer tissue samples and promotes the malignant phenotype through EMT (Montrer ITK Anticorps) and the ERK (Montrer EPHB2 Anticorps)/MMP2 (Montrer MMP2 Anticorps) signaling pathway.
Rab5 was found abundantly localized in macrophage rich areas of human atherosclerotic lesions.Rab5 plays an important role in modulating the intracellular cholesterol of macrophages and consequently mediating the formation of foam cells.
The results were indicative that rabies virus N proficiently colocalized with Rab5/EEA1 (Montrer EEA1 Anticorps) and Rab7 (Montrer RAB7B Anticorps)/LAMP1 (Montrer LAMP1 Anticorps) in both cell lines at 24 and 48 h post-infection, while N titers significantly decreased in early infection of rabies virus.
Membrane localization and dynamics of geranylgeranylated Rab5 hypervariable region has been reported.
study elucidated a novel Malat1-miR-101-STMN1/RAB5A/ATG4D regulatory network that Malat1 activates autophagy and promotes cell proliferation by sponging miR-101 and upregulating STMN1, RAB5A and ATG4D expression in glioma cells
In conclusion, mutant KRAS promotes endosomal degradation in PDAC cell lines, which is impaired by KRAS silencing. Moreover, KRAS silencing activates RAB5A upregulation and drives PDAC subtype-dependent modulation of endosome trafficking.
The authors described a long-distance signaling mechanism of Porcine hemagglutinating encephalomyelitis virus-driven deficits in neurons and suggested that such Ulk1 (Montrer ULK1 Anticorps) repression may result in limited NGF (Montrer NGFB Anticorps)/TrkA (Montrer NTRK1 Anticorps) retrograde signaling within activated Rab5 endosomes, explaining the progressive failure of neurite outgrowth and survival.
SH3GLB1 (Montrer SH3GLB1 Anticorps) controls nicotinic acetylcholine receptors endocytic trafficking in a phosphorylation- and RAB5-dependent manner at steps upstream of autophagosome formation.
E. chaffeensis secretes Etf-1 (Montrer ETF1 Anticorps) to induce autophagy to repurpose the host cytoplasm and capture nutrients for its growth through RAB5 and class III PtdIns3K, while avoiding autolysosomal killing.
These data highlight a requirement of Rab5 and the endosomal system for the regulation of gluconeogenic gene expression that has important implications for metabolic diseases.
Inpp5e (Montrer INPP5E Anticorps), through functional interactions with Rab20 (Montrer RAB20 Anticorps) on the phagosome, activates Rab5, which, in turn, increases PtdIns3P and delays phagosome acidification.
FGF21 (Montrer FGF21 Anticorps) has a role in promoting endothelial cell angiogenesis through a dynamin-2 (Montrer DNM2 Anticorps) and Rab5 dependent pathway
In silico screening for palmitoyl substrates reveals a role for DHHC1/3/10 (zDHHC1/3/11)-mediated neurochondrin (Montrer NCDN Anticorps) palmitoylation in its targeting to Rab5-positive endosomes.
In mammalian cells, p110beta acts as a molecular sensor for growth factor availability and induces autophagy by activating a Rab5-mediated signaling cascade.
Data show that Rinl is closely associated with the cytoskeleton and thus contributes to the spatial control of Rab5a and Rab22 signaling at actin-positive compartments.
Data reveal the affinity of Rabex-5 (Montrer RABGEF1 Anticorps)/Rabaptin-5 (Montrer RABEP1 Anticorps)/Rab5-GTP (Montrer AK3 Anticorps) interaction in the cell, which is quantitatively related to the Rabex-5 (Montrer RABGEF1 Anticorps) concentration for the onset of the indirect
Expression of dominant negative Rab5 and Rab7 (Montrer RAB7A Anticorps) mutants, but not the dominant negative Rab11 (Montrer RAB11A Anticorps) mutant, significantly inhibited classical swine fever virus replication. These results were confirmed by silencing of Rab5 and Rab7 (Montrer RAB7A Anticorps).
Dominant-negative mutant rab5 inhibits FMDV infection of IBRS-2 cells.
Rab5-mediated endocytosis of E-cadherin (Montrer CDH1 Anticorps) is enhanced at the boundary between normal and RasV12 cells.
Required for the fusion of plasma membranes and early endosomes (By similarity).
RAS-associated protein RAB5A
, ras-related protein Rab-5A
, rab5A protein
, Rab5a, GTPase
, hypothetical protein
, Ras-related protein Rab-5A
, ras-related protein rab-5a
, small GTP-binding protein rab5
, GTP-binding protein (rab5)
, RAB5A, member RAS oncogene family
, RAB5A, member RAS oncogene family, a