Aperçu des produits pour anti-C5A (C5a) Anticorps

Human Complement Component 5a (C5a) interaction partners

1. In addition, an in vitro experiment revealed C5aR deficiency promoted the development of regulatory T cells whereas C5a activation abolished the differentiation of regulatory T cells.

2. Urinary C5a correlates with the degree of kidney donor acute kidney injury. In the absence of clinical donor AKI, donor urinary C5a concentrations associate with recipient delayed graft function.

3. REVIEW: Emerging roles in cancer progression and treatment

4. the placental C5a/C5aR pathway contributed to the development of pre eclampsia by regulating placental trophoblasts dysfunctions.

5. Aspergillus fumigatus conidial metalloprotease Mep1p cleaves host major complement components C3, C4, and C5.

6. Furthermore, Apigenin reduced the proliferation of human NPC cells triggered by C5a through negative regulation of C5aR/PCAF/STAT3 axis. These might provide a new insight into the function of Apigenin in cancer treatment, and also provide a potential strategy for treating human NPC through inhibition of C5aR expression on cancer cells

7. Study identified that peripheral mRNA expression levels of two complement genes (C5, SERPING1) made unique contributions to the variance in superior frontal cortical thickness. Vertex-wise maps of the association between gene expression levels and thickness across the cortex suggested that this relationship was especially strong with SERPING1 in the superior frontal region.

8. these data demonstrate that Mesenchymal Stem Cells inhibit the activation of pathogenic C5 via up-regulation of FH, which improves our understanding of the immunomodulatory mechanisms of MSCs in the treatment of lupus nephritis.

9. recombinant C5a potentiated TNFalpha-induced NF-kappaB activation in renal tubular epithelial cells

10. tumoral C5a is an independent adverse prognostic biomarker for clinical outcome of Clear Cell Renal Cell Carcinoma patients after nephectomy.

11. C5a synergises with P. aeruginosa LPS in both PD-L1 expression and the production of IL-10 and TGF-beta.

12. these results not only confirm the critical role of C5b-9 in complement-mediated hemolysis and but also highlight the critical role of C5b-9 in inflammasome activation.

13. Mean cerebrospinal fluid C5 levels increased in patients with depression and schizophrenia.

14. elevated in the cerebrospinal fluid of preterm newborns

15. Up-regulation of granulocyte and monocyte CD11b during plasma separation was C5-dependent.

16. This study provides the preclinical rationale for the combined blockade of PD-1/PD-L1 and C5a to restore antitumor immune responses, inhibit tumor cell growth, and improve outcomes of patients with lung cancer

17. Diagnosis and therapeutic management of neonatal hemochromatosis cannot only be based on C5b9 expression in liver samples as it is not specific of this disease.

18. C5a-C5aR enriched clear cell renal cell carcinoma patients significantly had a poorer overall survival and recurrence free survival after nephrectomy.

19. The complement activation factors Bb, C3a, C5a, and MAC were increased significantly in early-onset severe pre-eclampsia (EOSPE) (all P<.01) and late-onset severe pre-eclampsia (LOSPE). (P value: .027, <.001, .001, and <.001, respectively) compared with E/L-control. C1q and C4d were increased significantly in LOSPE (P value: .003 and .014, respectively) compared with L-control.

20. C5a/C5aR pathway promotes gastric cancer pathogenesis by suppressing p21/p-p21 expression via activation of PI3K/AKT signaling.