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Human Monoclonal GRAP2 Primary Antibody pour FACS, IP - ABIN509570
Yankee, Draves, Ewings, Clark, Graves: CD95/Fas induces cleavage of the GrpL/Gads adaptor and desensitization of antigen receptor signaling. dans Proceedings of the National Academy of Sciences of the United States of America 2001
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Human Polyclonal GRAP2 Primary Antibody pour ELISA, WB - ABIN256936
Qiu, Hua, Agrawal, Li, Cai, Chan, Zhou, Luo, Liu: Molecular cloning and expression of human grap-2, a novel leukocyte-specific SH2- and SH3-containing adaptor-like protein that binds to gab-1. dans Biochemical and biophysical research communications 1999
These data are consistent with a model in which bivalent recruitment of a GADS/SLP-76 (Montrer LCP2 Anticorps) complex is required for costimulation by CD6 (Montrer CD6 Anticorps).
Following phosphorylation of the tyrosine, the proteins growth factor receptor-bound protein 2 (Grb2 (Montrer GRB2 Anticorps)), Grb2 (Montrer GRB2 Anticorps)-related adaptor downstream of Shc (Montrer SHC1 Anticorps) (Gads), and p85 subunit of phosphoinositide 3-kinase may bind to pYMNM (where pY is phosphotyrosine) via their Src (Montrer SRC Anticorps) homology 2 (SH2) domains, leading to downstream signaling to distinct immune pathways. These three adaptor proteins bind to the same site on CD28 (Montrer CD28 Anticorps) with variable affinity
GADS deficient T cells displayed similar levels of T cell receptor -induced SLP-76 (Montrer LCP2 Anticorps) and PLC-gamma1 (Montrer PLCG1 Anticorps) phosphorylation but exhibited substantial decrease in TCR-induced IL-2 (Montrer IL2 Anticorps) and IFN-gamma (Montrer IFNG Anticorps) release.
Gads was dispensable for TCR-induced phosphorylation of SLP-76 (Montrer LCP2 Anticorps), but was a dose-dependent amplifier of TCR-induced CD69 (Montrer CD69 Anticorps) expression.
GADS mediates lymphoid disease downstream of BCR-ABL (Montrer ABL1 Anticorps) through the recruitment of specific signaling intermediates.
Histidine domain-protein tyrosine phosphatase (Montrer ACP1 Anticorps) interacts with Grb2 (Montrer GRB2 Anticorps) and GrpL
The results show that Bcr-Abl (Montrer ABL1 Anticorps) regulates the actin cytoskeleton and non-apoptotic membrane blebbing via a GADS/Slp-76 (Montrer LCP2 Anticorps)/Nck1 (Montrer NCK1 Anticorps) adaptor protein pathway.
Exogenous expression of GrpL in a GrpL-negative B cell line leads to enhanced antigen receptor-induced extracellular signal-related kinase and p38 mitogen-activated protein kinase (Montrer MAPK14 Anticorps) phosphorylation.
AML-1 (Montrer RUNX1 Anticorps) plays a role in driving Mona (Montrer MMP2 Anticorps) protein expression in T and myelomonocytic cells.
Plays a tissue-specific role as an inhibitor of RET receptor tyrosine kinase (Montrer RET Anticorps) mitogenic signaling
High GADS expression is associated with neoplasms.
The combined loss of Gads and CD127 (Montrer IL7R Anticorps) reveals a novel function of Gads prior to T cell receptor beta expression
Data show that the primary function of Gads is to regulate the sensitivity of the TCR to Ag ligation.
Induced expression and association of the Mona/Gads adapter and Gab3 scaffolding protein (Montrer GAB3 Anticorps) during monocyte/macrophage differentiation. (Gab3 scaffolding protein (Montrer GAB3 Anticorps))
Results reveal the basis for preferential recognition of specific LAT (Montrer LAT Anticorps) sites by Gads.
Mona/Gads SH3C binding to hematopoietic progenitor kinase 1 (HPK1 (Montrer MAP4K1 Anticorps)) combines an atypical SH3 binding motif, R/KXXK, with a classical PXXP motif embedded in a polyproline type II (PPII) helix
The Gads adaptor protein is critical for homeostasis of CD4 (Montrer CD4 Anticorps)(+) T cells.
Selective impairment of FcepsilonRI (Montrer FCER1A Anticorps)-mediated allergic reaction in Gads-deficient mice
Gads plays a key role in linking the adapter LAT (Montrer LAT Anticorps) to SLP-76 (Montrer LCP2 Anticorps) in response to weak activation of GPVI (Montrer GP6 Anticorps) and CLEC-2 (Montrer CLEC1B Anticorps) whereas LAT (Montrer LAT Anticorps) is required for full activation over a wider range of agonist concentrations.
This gene encodes a member of the GRB2/Sem5/Drk family. This member is an adaptor-like protein involved in leukocyte-specific protein-tyrosine kinase signaling. Like its related family member, GRB2-related adaptor protein (GRAP), this protein contains an SH2 domain flanked by two SH3 domains. This protein interacts with other proteins, such as GRB2-associated binding protein 1 (GAB1) and the SLP-76 leukocyte protein (LCP2), through its SH3 domains. Transcript variants utilizing alternative polyA sites exist.
GRB2-related adaptor protein 2
, GRB2-related adapter protein 2
, GRB-2-like protein
, GRB2-related protein with insert domain
, SH3-SH2-SH3 adapter Mona
, SH3-SH2-SH3 adaptor molecule
, adapter protein GRID
, grf40 adapter protein
, growth factor receptor-binding protein
, growth factor receptor-bound protein 2-related adaptor protein 2
, hematopoietic cell-associated adapter protein GrpL
, hematopoietic cell-associated adaptor protein GRPL
, GRB-2-related monocytic adapter protein
, Grb2-related adaptor downstream of Sch
, hematopoietic cell-associated adaptor protein GrpL
, monocytic adapter
, monocytic adaptor