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Human Polyclonal Glutathione Peroxidase 2 Primary Antibody pour IHC, ELISA - ABIN250547
Esworthy, Yang, Frankel, Chu: Epithelium-specific glutathione peroxidase, Gpx2, is involved in the prevention of intestinal inflammation in selenium-deficient mice. dans The Journal of nutrition 2005
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Human Polyclonal Glutathione Peroxidase 2 Primary Antibody pour ELISA, WB - ABIN185424
McGrath-Morrow, Lauer, Yee, Neptune, Podowski, Thimmulappa, OReilly, Biswal: Nrf2 increases survival and attenuates alveolar growth inhibition in neonatal mice exposed to hyperoxia. dans American journal of physiology. Lung cellular and molecular physiology 2009
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GPx2 may play an important role in the development of nasopharyngeal carcinoma. Furthermore, GPx2 may serve as a prognostic biomarker for NPC (Montrer NPC1 Anticorps) patient.
Yes associated protein 1 (YAP (Montrer YAP1 Anticorps)) activation led to excessive accumulation of reactive oxygen species (ROS (Montrer ROS1 Anticorps)) by downregulating the antioxidant enzyme glutathione peroxidase GPX2 (Montrer GPX1 Anticorps) in a manner related to tumor protein p63 (Montrer TP63 Anticorps) blockade.
Results showed that the expression of GPX2 was significantly up-regulated within esophageal squamous cell carcinoma tissues.
Glutathione peroxidase 2 expression is a novel independent prognostic biomarker for gastric carcinoma that may be used to devise personalized therapeutic regimens and precision treatments for this disease
glutathione peroxidase 2 overexpression contributes to poor prognosis of hepatocellular carcinoma patients and helps to identify the high-risk hepatocellular carcinoma patients.
Cardamonin exposure and selenium availability regulate expression of HO-1 (Montrer HMOX1 Anticorps), GPX2 and TrxR1 (Montrer TXNRD1 Anticorps) in human intestinal cells.
GPX2 underexpression is associated with advanced tumor status and implicated unfavorable clinical outcome of UCs, suggesting its role in tumor progression and may serve as a theranostic biomarker of UCs.
high GPx2 expression was associated with early tumor recurrence, particularly in the recently identified aggressive subtype of human colon cancer.
Patients with high GPX2 expression in biopsy specimen had significantly lower prostate-specific antigen recurrence-free survival and overall survival than those with no GPX2 expression.
miR (Montrer MLXIP Anticorps)-185 plays a role in up-regulation of GPX2 and SEPHS2 (Montrer SEPHS2 Anticorps) expression.
The authors cloned cytosolic glutathione peroxidase (GPx1 (Montrer GPX1 Anticorps)) and phospholipid hydroperoxide glutathione peroxidase (GPx4 (Montrer GPX4 Anticorps)) genes in rainbow trout (Oncorhynchus mykiss). Constitutive mRNA expression and responsiveness to Se availability was analysed.
High glutathione peroxidase 2 expression is associated with radiation induced lung disease.
we propose that ileocolitis in the GPx1 (Montrer GPX1 Anticorps)/2-double-knockout mice is caused by Nox1 (Montrer NOX1 Anticorps), which is induced by TNF (Montrer TNF Anticorps)
GPx2 is up-regulated in dysplastic colonic crypts, where it appears to act inhibit apoptosis and, thus, supports tumor development.
Candidate colitis genes in the Gdac1 locus of mice deficient in glutathione peroxidase-1 (Montrer GPX1 Anticorps) and -2, were analyzed.
it is concluded that GPx2, although supporting tumor growth, inhibits inflammation-mediated tumorigenesis, but the protective effect of selenium does not strictly depend on GPx2 expression
study indicates GI-GPx is spatiotemporally expressed in embryonic organs during organogenesis and may also perform a mutual compensatory role with cGPx (Montrer GPX1 Anticorps) in protecting embryos and extraembryonic tissues against reactive oxygen species
Loss of Gpx2 is associated with diet induced severe colitis.
In GPx2 KO mice, an increase in GPx1 (Montrer GPX1 Anticorps) can only partially compensate for GPx2, even under selenium supplementation, indicating that GPx2 is the major antiapoptotic GPx (Montrer PRDX6 Anticorps) in the colon.
Genes encoding the antioxidants GPX2 and GSTO 1-1 (Montrer GSTO1 Anticorps) are common inflammatory genes expressed upon induction of allergic airway inflammation, and independently of allergic susceptibility.
GPX1 (Montrer GPX1 Anticorps)-DKO and GPX2-DKO mice are highly susceptible to bacteria-associated inflammation and cancer.
This gene is a member of the glutathione peroxidase family and encodes a selenium-dependent glutathione peroxidase that is one of two isoenzymes responsible for the majority of the glutathione-dependent hydrogen peroxide-reducing activity in the epithelium of the gastrointestinal tract. The protein encoded by this locus contains a selenocysteine (Sec) residue encoded by the UGA codon, which normally signals translation termination. Alternatively spliced transcript variants have been described.
gastrointestinal glutathione peroxidase
, glutathione peroxidase 2
, glutathione peroxidase-related protein 2
, glutathione peroxidase type 2
, glutathione peroxidase-gastrointestinal
, intestinal GPx