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EIF2AK2 anticorps (pThr446)

Il existe 1 publication pour ce produit. L’anticorps anti-EIF2AK2 Polyclonal Lapin est utilisé pour la détection de EIF2AK2 dans des échantillons de Humain. Il a été validé pour WB, IHC et IF.

(1 reference)

N° du produit ABIN362357

268,40 €

Plus frais de livraison 40,00 € et TVA

Destination: France

Envoi sous 10 à 14 jours ouvrables

Aperçu rapide pour EIF2AK2 anticorps (pThr446) (ABIN362357)

Antigène

Voir toutes EIF2AK2 Anticorps

EIF2AK2 (Eukaryotic Translation Initiation Factor 2-alpha Kinase 2 (EIF2AK2))

Reactivité

Humain

Hôte

Lapin

Clonalité

Polyclonal

Conjugué

Cet anticorp EIF2AK2 est non-conjugé

Application

Western Blotting (WB), Immunohistochemistry (IHC), Immunofluorescence (IF)

Discover our top product EIF2AK2 Anticorps primaire

Épitope
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pThr446

Specificité

The antibody detects endogenous level of PKR only when phosphorylated at threonine 446.

Purification

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography usingepitope-specific phosphopeptide. The antibody against non-phosphopeptide was removedby chromatography using non-phosphopeptide corresponding to the phosphorylation site.

Immunogène

Peptide sequence around phosphorylation site of pThr446 (K-R-T (p) -R-S) derived from Human PKR. Antibodies were produced by immunizing rabbits with synthetic phosphopeptide and KLH conjugates.

Isotype

IgG
anti-Eukaryotic Translation Initiation Factor 2-alpha Kinase 2 (EIF2AK2) (AA 1-100) antibody
EIF2AK2 Reactivité: Humain WB, ELISA, IF, IHC (p) Hôte: Souris Monoclonal 1D11 unconjugated

anti-Eukaryotic Translation Initiation Factor 2-alpha Kinase 2 (EIF2AK2) (AA 1-100) antibody
EIF2AK2 Reactivité: Humain WB, ELISA, IF, IHC (p) Hôte: Souris Monoclonal 1B9 unconjugated

anti-Eukaryotic Translation Initiation Factor 2-alpha Kinase 2 (EIF2AK2) (AA 329-551) antibody
EIF2AK2 Reactivité: Humain WB, IHC, ELISA, FACS Hôte: Souris Monoclonal 6H3A10 unconjugated

anti-Eukaryotic Translation Initiation Factor 2-alpha Kinase 2 (EIF2AK2) (AA 224-502) antibody
EIF2AK2 Reactivité: Humain WB, IHC, IP, ICC, FACS Hôte: Lapin Polyclonal unconjugated

anti-Eukaryotic Translation Initiation Factor 2-alpha Kinase 2 (EIF2AK2) antibody
KD Validated EIF2AK2 Reactivité: Humain WB, FACS Hôte: Souris Monoclonal 24GB7125 unconjugated

anti-Eukaryotic Translation Initiation Factor 2-alpha Kinase 2 (EIF2AK2) (AA 1-100) antibody
EIF2AK2 Reactivité: Humain WB, ELISA, IF Hôte: Souris Monoclonal 2C2 unconjugated

anti-Eukaryotic Translation Initiation Factor 2-alpha Kinase 2 (EIF2AK2) (pThr451) antibody
KD Validated EIF2AK2 Reactivité: Humain WB, FACS Hôte: Lapin Monoclonal 23GB1710 unconjugated Recombinant Antibody

anti-Eukaryotic Translation Initiation Factor 2-alpha Kinase 2 (EIF2AK2) (AA 117-250) antibody
EIF2AK2 Reactivité: Humain WB, IHC, IF, IP Hôte: Souris Monoclonal 13-PKR unconjugated

anti-Eukaryotic Translation Initiation Factor 2-alpha Kinase 2 (EIF2AK2) (AA 519-550) antibody
EIF2AK2 Reactivité: Humain, Souris WB, IHC, ELISA Hôte: Lapin Polyclonal unconjugated

anti-Eukaryotic Translation Initiation Factor 2-alpha Kinase 2 (EIF2AK2) (AA 11-42) antibody
EIF2AK2 Reactivité: Humain, Souris WB, IHC, ELISA Hôte: Lapin Polyclonal unconjugated

Indications d'application

Western blotting: 1:500-1:1000
Immunohistochemistry: 1:50-1:100
Immunofluorescence: 1:100-1:200

Restrictions

For Research Use only
Format

Liquid

Concentration

1 mg/mL

Buffer

Phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.

Agent conservateur

Sodium azide

Précaution d'utilisation

This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock

4 °C/-20 °C

Stockage commentaire

Store at -20 °C for long term preservation (recommended). Store at 4 °C for short term use.
Laing, Wang, Briazova, Zhang, Wang, Zheng, Gow, Chen, Rajagopalan, Chen, Sun, Zhang: "Airborne particulate matter selectively activates endoplasmic reticulum stress response in the lung and liver tissues." dans: American journal of physiology. Cell physiology, Vol. 299, Issue 4, pp. C736-49, (2010) (PubMed).
Antigène

EIF2AK2 (Eukaryotic Translation Initiation Factor 2-alpha Kinase 2 (EIF2AK2))

Autre désignation

PKR

Sujet

Following activation by double-stranded RNA in the presence of ATP, the kinase becomes autophosphorylated and can catalyze the phosphorylation of the translation initiation factor EIF2S1, which leads to an inhibition of the initiation of protein synthesis. Double-stranded RNA is generated during the course of a viral infection.

Poids moléculaire

68 kDa

NCBI Accession

NP_001129

UniProt

P19525

Pathways

Réparation de l'ADN, ER-Nucleus Signaling, Hepatitis C