PPM1D anticorps (C-Term)
(8 références)Aperçu rapide pour PPM1D anticorps (C-Term) (ABIN392853)
Antigène
Voir toutes PPM1D AnticorpsReactivité
Hôte
Clonalité
Conjugué
Application
Clone
-
-
Épitope
- AA 571-602, C-Term
-
Purification
- This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.
-
Immunogène
- This PPM1D antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 571-602 amino acids from the C-terminal region of human PPM1D.
-
Isotype
- Ig Fraction
-
-
anti-Protein Phosphatase, Mg2+/Mn2+ Dependent, 1D (PPM1D) (AA 201-300) antibody
PPM1D Reactivité: Humain WB, ELISA, IF (cc), IHC (p) Hôte: Lapin Polyclonal unconjugated
anti-Protein Phosphatase, Mg2+/Mn2+ Dependent, 1D (PPM1D) (AA 496-605) antibodyPPM1D Reactivité: Humain WB, ELISA Hôte: Souris Monoclonal 4D1 unconjugated
anti-Protein Phosphatase, Mg2+/Mn2+ Dependent, 1D (PPM1D) (AA 1-250) antibodyPPM1D Reactivité: Humain WB, ELISA, IHC Hôte: Lapin Polyclonal unconjugated
anti-Protein Phosphatase, Mg2+/Mn2+ Dependent, 1D (PPM1D) (AA 183-212) antibodyPPM1D Reactivité: Humain WB Hôte: Lapin Polyclonal RB33957 unconjugated
anti-Protein Phosphatase, Mg2+/Mn2+ Dependent, 1D (PPM1D) (C-Term) antibodyPPM1D Reactivité: Humain WB Hôte: Lapin Polyclonal unconjugated
anti-Protein Phosphatase, Mg2+/Mn2+ Dependent, 1D (PPM1D) antibodyPPM1D Reactivité: Humain, Souris WB, ELISA, IHC (p), ICC, ICFC Hôte: Souris Monoclonal 7E11-C5 unconjugated
-
-
Indications d'application
- WB: 1:1000
-
Restrictions
- For Research Use only
-
-
-
Format
- Liquid
-
Buffer
- Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.
-
Agent conservateur
- Sodium azide
-
Précaution d'utilisation
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
-
Stock
- 4 °C,-20 °C
-
Stockage commentaire
- Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C.
-
Date de péremption
- 6 months
-
-
-
: "p53-Independent expression of wild-type p53-induced phosphatase 1 (Wip1) in methylmethane sulfonate-treated cancer cell lines and human tumors." dans: The international journal of biochemistry & cell biology, Vol. 44, Issue 6, pp. 896-904, (2012) (PubMed).
: "Expression of a homeostatic regulator, Wip1 (wild-type p53-induced phosphatase), is temporally induced by c-Jun and p53 in response to UV irradiation." dans: The Journal of biological chemistry, Vol. 285, Issue 12, pp. 9067-76, (2010) (PubMed).
: "Wild-type p53-induced phosphatase 1 dephosphorylates histone variant gamma-H2AX and suppresses DNA double strand break repair." dans: The Journal of biological chemistry, Vol. 285, Issue 17, pp. 12935-47, (2010) (PubMed).
: "Oncogenic Wip1 phosphatase is inhibited by miR-16 in the DNA damage signaling pathway." dans: Cancer research, Vol. 70, Issue 18, pp. 7176-86, (2010) (PubMed).
: "The oncogenic phosphatase WIP1 negatively regulates nucleotide excision repair." dans: DNA repair, Vol. 9, Issue 7, pp. 813-23, (2010) (PubMed).
: "BRCA1-IRIS overexpression abrogates UV-induced p38MAPK/p53 and promotes proliferation of damaged cells." dans: Oncogene, Vol. 29, Issue 38, pp. 5274-85, (2010) (PubMed).
: "Phosphorylation and degradation of MdmX is inhibited by Wip1 phosphatase in the DNA damage response." dans: Cancer research, Vol. 69, Issue 20, pp. 7960-8, (2009) (PubMed).
: "The estrogen receptor alpha pathway induces oncogenic Wip1 phosphatase gene expression." dans: Molecular cancer research : MCR, Vol. 7, Issue 5, pp. 713-23, (2009) (PubMed).
-
-
- PPM1D (Protein Phosphatase, Mg2+/Mn2+ Dependent, 1D (PPM1D))
-
Autre désignation
- PPM1D
-
Sujet
- PPM1D is a member of the PP2C family of Ser/Thr protein phosphatases. PP2C family members are known to be negative regulators of cell stress response pathways. Expression of this PPM1D gene is induced in a p53-dependent manner in response to various environmental stresses. While being induced by tumor suppressor protein TP53/p53, this phosphatase negatively regulates the activity of p38 MAP kinase, MAPK/p38, through which it reduces the phosphorylation of p53, and in turn suppresses p53-mediated transcription and apoptosis. This phosphatase thus mediates a feedback regulation of p38-p53 signaling that contributes to growth inhibition and the suppression of stress induced apoptosis. The PPM1D gene is located in a chromosomal region known to be amplified in breast cancer. The amplification of this gene has been detected in both breast cancer cell line and primary breast tumors, which suggests a role of this gene in cancer development.
-
Poids moléculaire
- 66675
-
NCBI Accession
- NP_003611
-
UniProt
- O15297
-
Pathways
- Signalisation p53, Cycle Cellulaire
Antigène
-
