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DNA methylation is the major modification of eukaryotic genomes and plays an essential role in mammalian development. De plus, nous expédions et beaucoup plus de produits pour cette protéine.
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Human Polyclonal MBD2 Primary Antibody pour EIA, WB - ABIN356599
Zhu, Spitz, Zhang, Grossman, Frazier, Wu: Methyl-CpG-binding domain 2: a protective role in bladder carcinoma. dans Cancer 2004
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Human Polyclonal MBD2 Primary Antibody pour IF, WB - ABIN1881531
Liu, Wu, Chen, Ter-Minassian, Asomaning, Zhai, Wang, Su, Heist, Kulke, Lin, Liu, Christiani: A Large-scale genetic association study of esophageal adenocarcinoma risk. dans Carcinogenesis 2010
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Human Polyclonal MBD2 Primary Antibody pour IHC (p), IHC - ABIN188691
Tan, Nakielny: Control of the DNA methylation system component MBD2 by protein arginine methylation. dans Molecular and cellular biology 2006
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Human Polyclonal MBD2 Primary Antibody pour WB - ABIN387915
Ghoshal, Majumder, Datta, Motiwala, Bai, Sharma, Frankel, Jacob: Role of human ribosomal RNA (rRNA) promoter methylation and of methyl-CpG-binding protein MBD2 in the suppression of rRNA gene expression. dans The Journal of biological chemistry 2004
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Human Polyclonal MBD2 Primary Antibody pour GS, WB - ABIN151224
Ballestar, Paz, Valle, Wei, Fraga, Espada, Cigudosa, Huang, Esteller: Methyl-CpG binding proteins identify novel sites of epigenetic inactivation in human cancer. dans The EMBO journal 2003
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Human Polyclonal MBD2 Primary Antibody pour IHC, ELISA - ABIN334432
Auriol, Billard, Magdinier, Dante: Specific binding of the methyl binding domain protein 2 at the BRCA1-NBR2 locus. dans Nucleic acids research 2005
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Human Polyclonal MBD2 Primary Antibody pour WB - ABIN2779675
Xing, Stewart, Gu, Lu, Spitz, Wu: Expression of methylation-related genes is associated with overall survival in patients with non-small cell lung cancer. dans British journal of cancer 2008
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Dog (Canine) Polyclonal MBD2 Primary Antibody pour EIA, IHC (p) - ABIN375214
Spruijt, Bartels, Brinkman, Tjeertes, Poser, Stunnenberg, Vermeulen: CDK2AP1/DOC-1 is a bona fide subunit of the Mi-2/NuRD complex. dans Molecular bioSystems 2010
Chicken Polyclonal MBD2 Primary Antibody pour WB - ABIN2778640
Le Guezennec, Vermeulen, Brinkman, Hoeijmakers, Cohen, Lasonder, Stunnenberg: MBD2/NuRD and MBD3/NuRD, two distinct complexes with different biochemical and functional properties. dans Molecular and cellular biology 2006
Human Polyclonal MBD2 Primary Antibody pour ICC, IF - ABIN257102
Kim, Kwak, Weitz: Specificity in circadian clock feedback from targeted reconstitution of the NuRD corepressor. dans Molecular cell 2014
downregulation of miR (Montrer MLXIP Anticorps)-221 inhibits cell migration and invasion at least partially through targeting MBD2 (Montrer DPEP2 Anticorps) in the human OSCC cell line UM1.
Specifically, methyl-CpG-binding domain protein 2 (MBD2) is revealed to be recruited to DNA damage sites after laser microirradiation, which was mediated through MBD (Montrer DPEP1 Anticorps) domain and MBD2 (Montrer DPEP2 Anticorps) C-terminus.
MBD2 targets short interspersed nuclear elements, but does not exclude RNA Polymerase III.
The dynamics of MBD2 (Montrer DPEP2 Anticorps) deposition across methylated DNA regions was associated with the oncogenic transformation of human mammary cells.
Data suggest that MBD2 (Montrer DPEP2 Anticorps) binds primarily at highly methylated regions, with a strong preference for CpG islands and highlights that MBD2 (Montrer DPEP2 Anticorps) binding sites display increased methylation in primary breast cancer tissues as compared to normal mammary cells.
Biophysical analyses show that the MBD2IDR is an intrinsically disordered region (IDR). However, despite this inherent disorder, MBD2IDR increases the overall binding affinity of MBD2 (Montrer DPEP2 Anticorps) for methylated DNA.
This study investigates the genetic association between methyl-CpG-binding domain (MBD (Montrer DPEP1 Anticorps)) gene polymorphisms and schizophrenia.
The methylated-DNA binding protein (Montrer UBE2V1 Anticorps) MBD2 (Montrer DPEP2 Anticorps) enhances NGFI-A (egr-1 (Montrer EGR1 Anticorps))-mediated transcriptional activation of the glucocorticoid receptor (Montrer NR3C1 Anticorps).
These data point to a potential new approach in targeting the DNA methylation (Montrer HELLS Anticorps) machinery by combination of MBD2 (Montrer DPEP2 Anticorps) and DNMT (Montrer DNMT1 Anticorps) inhibitors.
MBD2 (Montrer DPEP2 Anticorps) seems to play a selective role in gene repression depending on the CpG content of the promoter region
Mbd2 has a key role regulating expression of a range of genes that are associated with optimal dendritic cell activation and function.
methyl-CpG-binding domain protein 2 (MBD2), an epigenetic regulator, controls autoimmunity and EAE through T-bet/Hlx (Montrer HLX Anticorps).
Biophysical analyses show that the MBD2IDR is an intrinsically disordered region (IDR). However, despite this inherent disorder, MBD2IDR increases the overall binding affinity of MBD2 for methylated DNA.
miR (Montrer MLXIP Anticorps)-290/371-Mbd2-Myc (Montrer MYC Anticorps) circuit regulates glycolytic metabolism to promote pluripotency.
these findings suggest that CpG methylation and MBD2 are involved in altering Scn3a (Montrer SCN3A Anticorps) expression during postnatal development and seizure condition.
Data suggest that methyl-CpG binding domain protein 2 (MBD2) gene knockout may lead to accumulation of more deposits on the Bruch's membrane (BM) and influence the pathogenesis of age-related macular degeneration (AMD (Montrer AMD1 Anticorps)).
In metastatic colorectal cancer cells, reduced levels of miR (Montrer MLXIP Anticorps)-221* and miR (Montrer MLXIP Anticorps)-224 increase levels of MBD2, thereby decreasing expression of the metastasis suppressor maspin (Montrer SERPINB5 Anticorps).
Mbd2 has a key role in promoting the Treg-specific demethylation region demethylation, Foxp3 (Montrer FOXP3 Anticorps) expression, and Treg-suppressive function.
Our results strengthen the possibility that MeCP2 (Montrer MECP2 Anticorps) and MBD2 direct interactions could crosslink chromatin fibers and therefore give novel insight into the molecular mechanism of MBD (Montrer DPEP1 Anticorps) mediated global heterochromatin architecture.
DNA methylation is the major modification of eukaryotic genomes and plays an essential role in mammalian development. Human proteins MECP2, MBD1, MBD2, MBD3, and MBD4 comprise a family of nuclear proteins related by the presence in each of a methyl-CpG binding domain (MBD). Each of these proteins, with the exception of MBD3, is capable of binding specifically to methylated DNA. MECP2, MBD1 and MBD2 can also repress transcription from methylated gene promoters. The protein encoded by this gene may function as a mediator of the biological consequences of the methylation signal. It is also reported that the this protein functions as a demethylase to activate transcription, as DNA methylation causes gene silencing. Two transcript variants encoding different isoforms have been found for this gene.
methyl-CpG binding domain protein 2
, methyl-CpG-binding domain protein 2
, methyl-CpG-binding protein MBD2
, methyl-CpG binding protein MBD2