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anti-Methyl-CpG Binding Domain Protein 2 (MBD2) Anticorps

DNA methylation is the major modification of eukaryotic genomes and plays an essential role in mammalian development. De plus, nous expédions et beaucoup plus de produits pour cette protéine.

afficher tous les anticorps Gène GeneID UniProt
MBD2 8932 Q9UBB5
MBD2 17191 Q9Z2E1
MBD2 680172  
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Top anti-MBD2 Anticorps sur anticorps-enligne.fr

Showing 10 out of 128 products:

Catalogue No. Reactivité Hôte Conjugué Application Images Quantité Fournisseur Livraison Prix Détails
Humain Lapin Inconjugué WB WB Suggested Anti-MBD2 Antibody Titration: 0.2-1 ug/mlELISA Titer: 1:12500Positive Control: 721_B cell lysate 100 μL Connectez-vous pour afficher 6 to 8 Days
358,51 €
Détails
Chien Chèvre Inconjugué EIA, IHC (p), WB 0.1 mg Connectez-vous pour afficher 8 to 10 Days
357,50 €
Détails
Humain Lapin Inconjugué EIA, WB 0.4 mL Connectez-vous pour afficher 8 to 10 Days
407,00 €
Détails
Poulet Lapin Inconjugué WB WB Suggested Anti-MBD2 Antibody Titration: 0.625ug/mlELISA Titer: 1:1562500Positive Control: HepG2 cell lysate WB Suggested Anti-MBD2  Antibody Titration: 0.625 µg/mL ELISA Titer: 1:1562500  Positive Control: HepG2 cell lysate 100 μL Connectez-vous pour afficher 6 to 8 Days
288,68 €
Détails
Humain Chèvre Inconjugué IHC, ELISA, WB ABIN334432 (0.3µg/ml) staining of Jurkat cell lysate (35µg protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence. 100 μg Connectez-vous pour afficher 3 to 4 Days
349,82 €
Détails
Humain Lapin Inconjugué WB The anti-MBD2 N-term Antibody (ABIN387915) is used in Western blot to detect MBD2 in A375 cell lysate (lane 1) and mouse brain tissue lysate (lane 2) lysate. 400 μL Connectez-vous pour afficher 14 to 16 Days
335,24 €
Détails
Humain Lapin Inconjugué IF, WB MBD2 Antibody (Center) (ABIN1881531) western blot analysis in HL-60 cell line lysates (35 µg/lane). This demonstrates the MBD2 antibody detected the MBD2 protein (arrow). MBD2 Antibody (Center) (ABIN1881531) western blot analysis in HL-60 cell line lysates (35 µg/lane). This demonstrates the MBD2 antibody detected the MBD2 protein (arrow). 400 μL Connectez-vous pour afficher 14 to 16 Days
335,24 €
Détails
Humain Chèvre Inconjugué IHC (p), IHC, ELISA, WB ABIN188691 (0.3?g/ml) staining of Jurkat cell lysate (35?g protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence. Immunohistochemistry-Paraffin: MBD2 Antibody [ABIN1886915] - (2.5ug/ml) staining of paraffin embedded Human Colon. Steamed antigen retrieval with citrate buffer pH 6, AP-staining. 0.1 mg Connectez-vous pour afficher 3 to 5 Days
388,75 €
Détails
Humain Lapin Inconjugué ICC, IF, IHC, IHC (p), IP, WB Immunohistochemistry-Paraffin: MBD2 Antibody [ABIN2571027] - FFPE section of human prostate carcinoma. Dilution: 1:200 0.1 mL Connectez-vous pour afficher 3 to 5 Days
463,75 €
Détails
Humain Lapin Inconjugué GS, WB Anti-MBD2a antibody produced in rabbit 0.1 mL Connectez-vous pour afficher 3 to 5 Days
426,25 €
Détails

MBD2 Anticorps par réactivité, application, clonalité et conjugué

Attributs Application Hôte Clonalité Conjugué
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anti-MBD2 Anticorps mieux référencés

  1. Human Polyclonal MBD2 Primary Antibody pour EIA, WB - ABIN356599 : Zhu, Spitz, Zhang, Grossman, Frazier, Wu: Methyl-CpG-binding domain 2: a protective role in bladder carcinoma. dans Cancer 2004 (PubMed)
    Show all 5 references for ABIN356599

  2. Human Polyclonal MBD2 Primary Antibody pour IF, WB - ABIN1881531 : Liu, Wu, Chen, Ter-Minassian, Asomaning, Zhai, Wang, Su, Heist, Kulke, Lin, Liu, Christiani: A Large-scale genetic association study of esophageal adenocarcinoma risk. dans Carcinogenesis 2010 (PubMed)
    Show all 3 references for ABIN1881531

  3. Human Polyclonal MBD2 Primary Antibody pour IHC (p), IHC - ABIN188691 : Tan, Nakielny: Control of the DNA methylation system component MBD2 by protein arginine methylation. dans Molecular and cellular biology 2006 (PubMed)
    Show all 2 references for ABIN188691

  4. Human Polyclonal MBD2 Primary Antibody pour WB - ABIN387915 : Ghoshal, Majumder, Datta, Motiwala, Bai, Sharma, Frankel, Jacob: Role of human ribosomal RNA (rRNA) promoter methylation and of methyl-CpG-binding protein MBD2 in the suppression of rRNA gene expression. dans The Journal of biological chemistry 2004 (PubMed)
    Show all 2 references for ABIN387915

  5. Human Polyclonal MBD2 Primary Antibody pour GS, WB - ABIN151224 : Ballestar, Paz, Valle, Wei, Fraga, Espada, Cigudosa, Huang, Esteller: Methyl-CpG binding proteins identify novel sites of epigenetic inactivation in human cancer. dans The EMBO journal 2003 (PubMed)
    Show all 2 references for ABIN151224

  6. Human Polyclonal MBD2 Primary Antibody pour IHC, ELISA - ABIN334432 : Auriol, Billard, Magdinier, Dante: Specific binding of the methyl binding domain protein 2 at the BRCA1-NBR2 locus. dans Nucleic acids research 2005 (PubMed)
    Show all 2 references for ABIN334432

  7. Human Polyclonal MBD2 Primary Antibody pour WB - ABIN2779675 : Xing, Stewart, Gu, Lu, Spitz, Wu: Expression of methylation-related genes is associated with overall survival in patients with non-small cell lung cancer. dans British journal of cancer 2008 (PubMed)
    Show all 2 references for ABIN2779675

  8. Dog (Canine) Polyclonal MBD2 Primary Antibody pour EIA, IHC (p) - ABIN375214 : Spruijt, Bartels, Brinkman, Tjeertes, Poser, Stunnenberg, Vermeulen: CDK2AP1/DOC-1 is a bona fide subunit of the Mi-2/NuRD complex. dans Molecular bioSystems 2010 (PubMed)

  9. Chicken Polyclonal MBD2 Primary Antibody pour WB - ABIN2778640 : Le Guezennec, Vermeulen, Brinkman, Hoeijmakers, Cohen, Lasonder, Stunnenberg: MBD2/NuRD and MBD3/NuRD, two distinct complexes with different biochemical and functional properties. dans Molecular and cellular biology 2006 (PubMed)

  10. Human Polyclonal MBD2 Primary Antibody pour ICC, IF - ABIN257102 : Kim, Kwak, Weitz: Specificity in circadian clock feedback from targeted reconstitution of the NuRD corepressor. dans Molecular cell 2014 (PubMed)

Plus d’anticorps contre MBD2 partenaires d’interaction

Human Methyl-CpG Binding Domain Protein 2 (MBD2) interaction partners

  1. downregulation of miR (Montrer MLXIP Anticorps)-221 inhibits cell migration and invasion at least partially through targeting MBD2 (Montrer DPEP2 Anticorps) in the human OSCC cell line UM1.

  2. Specifically, methyl-CpG-binding domain protein 2 (MBD2) is revealed to be recruited to DNA damage sites after laser microirradiation, which was mediated through MBD (Montrer DPEP1 Anticorps) domain and MBD2 (Montrer DPEP2 Anticorps) C-terminus.

  3. MBD2 targets short interspersed nuclear elements, but does not exclude RNA Polymerase III.

  4. The dynamics of MBD2 (Montrer DPEP2 Anticorps) deposition across methylated DNA regions was associated with the oncogenic transformation of human mammary cells.

  5. Data suggest that MBD2 (Montrer DPEP2 Anticorps) binds primarily at highly methylated regions, with a strong preference for CpG islands and highlights that MBD2 (Montrer DPEP2 Anticorps) binding sites display increased methylation in primary breast cancer tissues as compared to normal mammary cells.

  6. Biophysical analyses show that the MBD2IDR is an intrinsically disordered region (IDR). However, despite this inherent disorder, MBD2IDR increases the overall binding affinity of MBD2 (Montrer DPEP2 Anticorps) for methylated DNA.

  7. This study investigates the genetic association between methyl-CpG-binding domain (MBD (Montrer DPEP1 Anticorps)) gene polymorphisms and schizophrenia.

  8. The methylated-DNA binding protein (Montrer UBE2V1 Anticorps) MBD2 (Montrer DPEP2 Anticorps) enhances NGFI-A (egr-1 (Montrer EGR1 Anticorps))-mediated transcriptional activation of the glucocorticoid receptor (Montrer NR3C1 Anticorps).

  9. These data point to a potential new approach in targeting the DNA methylation (Montrer HELLS Anticorps) machinery by combination of MBD2 (Montrer DPEP2 Anticorps) and DNMT (Montrer DNMT1 Anticorps) inhibitors.

  10. MBD2 (Montrer DPEP2 Anticorps) seems to play a selective role in gene repression depending on the CpG content of the promoter region

Mouse (Murine) Methyl-CpG Binding Domain Protein 2 (MBD2) interaction partners

  1. Mbd2 has a key role regulating expression of a range of genes that are associated with optimal dendritic cell activation and function.

  2. MBD2 targets short interspersed nuclear elements, but does not exclude RNA Polymerase III.

  3. methyl-CpG-binding domain protein 2 (MBD2), an epigenetic regulator, controls autoimmunity and EAE through T-bet/Hlx (Montrer HLX Anticorps).

  4. Biophysical analyses show that the MBD2IDR is an intrinsically disordered region (IDR). However, despite this inherent disorder, MBD2IDR increases the overall binding affinity of MBD2 for methylated DNA.

  5. miR (Montrer MLXIP Anticorps)-290/371-Mbd2-Myc (Montrer MYC Anticorps) circuit regulates glycolytic metabolism to promote pluripotency.

  6. these findings suggest that CpG methylation and MBD2 are involved in altering Scn3a (Montrer SCN3A Anticorps) expression during postnatal development and seizure condition.

  7. Data suggest that methyl-CpG binding domain protein 2 (MBD2) gene knockout may lead to accumulation of more deposits on the Bruch's membrane (BM) and influence the pathogenesis of age-related macular degeneration (AMD (Montrer AMD1 Anticorps)).

  8. In metastatic colorectal cancer cells, reduced levels of miR (Montrer MLXIP Anticorps)-221* and miR (Montrer MLXIP Anticorps)-224 increase levels of MBD2, thereby decreasing expression of the metastasis suppressor maspin (Montrer SERPINB5 Anticorps).

  9. Mbd2 has a key role in promoting the Treg-specific demethylation region demethylation, Foxp3 (Montrer FOXP3 Anticorps) expression, and Treg-suppressive function.

  10. Our results strengthen the possibility that MeCP2 (Montrer MECP2 Anticorps) and MBD2 direct interactions could crosslink chromatin fibers and therefore give novel insight into the molecular mechanism of MBD (Montrer DPEP1 Anticorps) mediated global heterochromatin architecture.

MBD2 profil antigène

Profil protéine

DNA methylation is the major modification of eukaryotic genomes and plays an essential role in mammalian development. Human proteins MECP2, MBD1, MBD2, MBD3, and MBD4 comprise a family of nuclear proteins related by the presence in each of a methyl-CpG binding domain (MBD). Each of these proteins, with the exception of MBD3, is capable of binding specifically to methylated DNA. MECP2, MBD1 and MBD2 can also repress transcription from methylated gene promoters. The protein encoded by this gene may function as a mediator of the biological consequences of the methylation signal. It is also reported that the this protein functions as a demethylase to activate transcription, as DNA methylation causes gene silencing. Two transcript variants encoding different isoforms have been found for this gene.

Gene names and symbols associated with MBD2

  • methyl-CpG binding domain protein 2 (MBD2) anticorps
  • methyl-CpG binding domain protein 2 (LOC100345590) anticorps
  • methyl-CpG binding domain protein 2 (Mbd2) anticorps
  • methyl-CpG binding domain protein 2 (mbd2) anticorps
  • DMTase anticorps
  • MBD2 anticorps
  • MBD2a anticorps
  • NY-CO-41 anticorps
  • wu:fa97f06 anticorps
  • zgc:111862 anticorps

Protein level used designations for MBD2

methyl-CpG binding domain protein 2 , demethylase , methyl-CpG-binding domain protein 2 , methyl-CpG-binding protein MBD2 , methyl-CpG binding protein MBD2

GENE ID SPECIES
455427 Pan troglodytes
100345590 Oryctolagus cuniculus
693801 Macaca mulatta
8932 Homo sapiens
17191 Mus musculus
337105 Danio rerio
399118 Xenopus laevis
497269 Gallus gallus
483975 Canis lupus familiaris
100337206 Bos taurus
680172 Rattus norvegicus
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