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anti-Runt-Related Transcription Factor 1, Translocated To, 1 (Cyclin D-Related) (RUNX1T1) Anticorps

RUNX1T1 encodes a member of the myeloid translocation gene family which interact with DNA-bound transcription factors and recruit a range of corepressors to facilitate transcriptional repression. De plus, nous expédions RUNX1T1 Protéines (6) et RUNX1T1 Kits (2) et beaucoup plus de produits pour cette protéine.

afficher tous les anticorps Gène GeneID UniProt
RUNX1T1 862 Q06455
RUNX1T1 12395 Q61909
RUNX1T1 362489  
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Top anti-RUNX1T1 Anticorps sur anticorps-enligne.fr

Showing 10 out of 38 products:

Catalogue No. Reactivité Hôte Conjugué Application Images Quantité Fournisseur Livraison Prix Détails
Poulet Lapin Inconjugué WB WB Suggested Anti-RUNX1T1 Antibody Titration: 0.2-1 ug/mlELISA Titer: 1:312500Positive Control: 293T cell lysate 100 μL Connectez-vous pour afficher 6 to 8 Days
358,51 €
Détails
Poulet Lapin Inconjugué WB WB Suggested Anti-RUNX1T1 Antibody Titration: 1.25ug/mlPositive Control: HepG2 cell lysate 100 μL Connectez-vous pour afficher 6 to 8 Days
288,68 €
Détails
Xenopus laevis Lapin Inconjugué WB Human 721_B; Host: Rabbit. Target Name: WT1 . Sample Tissue: 721_B . Antibody Dilution: 1.0ug/ml. RUNX1T1 is supported by BioGPS gene expression data to be expressed in 721_B.; RUNX1T1 antibody - middle region in Human 721_B cells using Western Blot Human HepG2; WB Suggested Anti-RUNX1T1 Antibody Titration: 1.25ug/ml. Positive Control: HepG2 cell lysate. There is BioGPS gene expression data showing that RUNX1T1 is expressed in HepG2.; RUNX1T1 antibody - middle region in Human HepG2 cells using Western Blot 0.1 mg Connectez-vous pour afficher 8 to 10 Days
357,50 €
Détails
Humain Souris Inconjugué IF, WB Anti-RUNX1T1 mouse monoclonal antibody (ABIN2455775) immunofluorescent staining of COS7 cells transiently transfected by pCMV6-ENTRY RUNX1T1 (RC222426). HEK293T cells were transfected with the pCMV6-ENTRY control (Left lane) or pCMV6-ENTRY RUNX1T1 (Right lane) cDNA for 48 hrs and lysed. Equivalent amounts of cell lysates (5 µg per lane) were separated by SDS-PAGE and immunoblotted with anti-RUNX1T1. 100 μL Connectez-vous pour afficher 6 to 8 Days
418,10 €
Détails
Humain Lapin Inconjugué WB 100 μg Connectez-vous pour afficher 11 to 14 Days
583,17 €
Détails
Humain Souris Inconjugué ELISA, WB Western Blot detection against Immunogen (38.21 KDa) . 50 μL Connectez-vous pour afficher 8 to 9 Days
241,60 €
Détails
Humain Lapin Inconjugué WB 100 μL Connectez-vous pour afficher 6 to 8 Days
358,51 €
Détails
Humain Lapin Inconjugué WB 50 μg Connectez-vous pour afficher 11 to 14 Days
653,02 €
Détails
Humain Souris Inconjugué WB Western Blot analysis of RUNX1T1 expression in transfected 293T cell line by RUNX1T1 monoclonal antibody (M01), clone 5A12. Lane 1: RUNX1T1 transfected lysate(67.566 KDa). Lane 2: Non-transfected lysate. Detection limit for recombinant GST tagged RUNX1T1 is approximately 0.3 ng/mL as a capture antibody. 0.1 mg Connectez-vous pour afficher 12 to 16 Days
454,76 €
Détails
Souris Lapin Inconjugué WB 50 μg Connectez-vous pour afficher 11 to 14 Days
653,02 €
Détails

RUNX1T1 Anticorps par réactivité, application, clonalité et conjugué

Attributs Application Hôte Clonalité
Human , , , ,
,
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Mouse (Murine) ,


Rat (Rattus) ,


anti-RUNX1T1 Anticorps mieux référencés

  1. Human Polyclonal RUNX1T1 Primary Antibody pour ELISA, WB - ABIN560189 : Abdelhaleem: RNA helicases: regulators of differentiation. dans Clinical biochemistry 2005 (PubMed)
    Show all 4 references for ABIN560189

  2. Chicken Polyclonal RUNX1T1 Primary Antibody pour WB - ABIN2787562 : Salat, Liefke, Wiedenmann, Borggrefe, Oswald: ETO, but not leukemogenic fusion protein AML1/ETO, augments RBP-Jkappa/SHARP-mediated repression of notch target genes. dans Molecular and cellular biology 2008 (PubMed)

  3. Xenopus laevis Polyclonal RUNX1T1 Primary Antibody pour WB - ABIN1108915 : Lausen, Cho, Liu, Werner: The nuclear receptor co-repressor (N-CoR) utilizes repression domains I and III for interaction and co-repression with ETO. dans The Journal of biological chemistry 2004 (PubMed)

Plus d’anticorps contre RUNX1T1 partenaires d’interaction

Human Runt-Related Transcription Factor 1, Translocated To, 1 (Cyclin D-Related) (RUNX1T1) interaction partners

  1. Our data revealed a novel role for RUNX1T1 as a tumor-suppressor gene in colorectal cancer through modulation of multiple cellular pathways affecting the cell cycle, DNA damage, DNA replication, estrogen signaling, and drug resistance

  2. Exon splicing patterns in the human RUNX1 (Montrer RUNX1 Anticorps)-RUNX1T1 fusion gene present in acute myeloid leukemia (Montrer BCL11A Anticorps) patients have been decoded.

  3. Data suggest that biosynthesis and folding of leukemogenic fusion oncoprotein AML1 (Montrer RUNX1 Anticorps)-ETO/RUNX1 (Montrer RUNX1 Anticorps)-RUNX1T1 is facilitated by interaction with the chaperonin (Montrer HSPD1 Anticorps) TRiC/CCT1/TCP1 and HSP70 (heat shock protein 70 (Montrer HSP70 Anticorps)).

  4. AML1/ETO transactivates gene expression through recruiting AP-1 to the AML1/ETO-AML1 complex.

  5. A substantial fraction of AML1 (Montrer RUNX1 Anticorps)-ETO/p300 (Montrer EP300 Anticorps) co-localization occurs near TSSs in promoter regions associated with transcriptionally active loci.

  6. minimal residual disease determined by RUNX1 (Montrer RUNX1 Anticorps)/RUNX1T1 transcript levels could identify allogeneic hematopoietic stem cell transplantation t(8;21) (q22;q22) acute myeloid leukemia (Montrer BCL11A Anticorps) patients who are at high risk for relapse, together with c-KIT (Montrer KIT Anticorps) mutations

  7. identify a high-frequency mutation in t(8;21)/RUNX1 (Montrer RUNX1 Anticorps)-RUNX1T1 acute myekoid leukemia (AML (Montrer RUNX1 Anticorps)) and identify the need for future studies to investigate the clinical and biological relevance of ASXL2 (Montrer ASXL2 Anticorps) mutations in this unique subset of AML (Montrer RUNX1 Anticorps)

  8. RUNX1 (Montrer RUNX1 Anticorps)/ETO-induced DNA damage and apoptosis in human primary CD34 (Montrer CD34 Anticorps)+ hematopoietic progenitors are rescued by activating c-Kit (Montrer KIT Anticorps) mutations

  9. In t(8;21) acute myelogenous leukemia (AML (Montrer RUNX1 Anticorps)), the acquisition of AML1 (Montrer RUNX1 Anticorps)/ETO is not sufficient, and the subsequent upregulation of AML1 (Montrer RUNX1 Anticorps)/ETO and the additional c-KIT (Montrer KIT Anticorps) mutant signaling are critical steps for transformation into leukemic stem cells.

  10. Our data shows that upregulated of the RUNX1 (Montrer RUNX1 Anticorps)-RUNX1T1 gene set maybe an important factor contributing to the etiology of ccRCC.

Mouse (Murine) Runt-Related Transcription Factor 1, Translocated To, 1 (Cyclin D-Related) (RUNX1T1) interaction partners

  1. Data show that RUNX1 (Montrer RUNX1 Anticorps)-ETO;c-Kit (Montrer KIT Anticorps)(T417IDelta418-419) coexpression promoted exclusively acute myeloid leukemia (Montrer BCL11A Anticorps) (AML (Montrer RUNX1 Anticorps)) in a fraction (51%) of reconstituted mice.

  2. Self-renewal induced by AML1 (Montrer RUNX1 Anticorps)/ETO in primary murine progenitors was inhibited when Aes (Montrer AES Anticorps) was decreased or absent.

  3. AML1 (Montrer RUNX1 Anticorps)-ETO synergizes with an ICSBP (Montrer IRF8 Anticorps) deficiency to induce myeloblastic transformation in the bone marrow, reminiscent of acute myelogenous leukemia

  4. molecular role for ETO in normal physiology as an inhibitor of C/EBPbeta (Montrer CEBPB Anticorps) and a novel regulator of early adipogenesis

  5. the loss of the molecular events of AML1 (Montrer RUNX1 Anticorps)-ETO C-terminal NCoR (Montrer NCOR1 Anticorps)/SMRT (Montrer NCOR2 Anticorps)-interacting domain transforms AML1 (Montrer RUNX1 Anticorps)-ETO into a potent leukemogenic protein

  6. p15(Ink4b (Montrer CDKN2B Anticorps)) loss must be accompanied by additional oncogenic changes for RUNX1 (Montrer RUNX1 Anticorps)-ETO-associated AML (Montrer RUNX1 Anticorps) to develop

  7. AML1 DNA-binding domain and the ETO NHR2-dimerization domain, but not the ETO NHR1 domain, are critical for the induction of acute myeloid leukemia by AML1-ETO9a

  8. the eTAFH-E protein interaction appears to contribute relatively little to the activity of AML1 (Montrer RUNX1 Anticorps)-ETO

RUNX1T1 profil antigène

Profil protéine

This gene encodes a member of the myeloid translocation gene family which interact with DNA-bound transcription factors and recruit a range of corepressors to facilitate transcriptional repression. The t(8\;21)(q22\;q22) translocation is one of the most frequent karyotypic abnormalities in acute myeloid leukemia. The translocation produces a chimeric gene made up of the 5'-region of the runt-related transcription factor 1 gene fused to the 3'-region of this gene. The chimeric protein is thought to associate with the nuclear corepressor/histone deacetylase complex to block hematopoietic differentiation. Alternative splicing results in multiple transcript variants.

Gene names and symbols associated with RUNX1T1

  • runt-related transcription factor 1; translocated to, 1 (cyclin D-related) (runx1t1) anticorps
  • runt-related transcription factor 1; translocated to, 1 (cyclin D-related) (RUNX1T1) anticorps
  • runt-related transcription factor 1; translocated to, 1 (cyclin D-related) (Runx1t1) anticorps
  • AML1T1 anticorps
  • Cbfa2t1 anticorps
  • Cbfa2t1h anticorps
  • CDR anticorps
  • ETO anticorps
  • MTG8 anticorps
  • si:ch211-232j17.1 anticorps
  • wu:fi14b07 anticorps
  • zgc:154044 anticorps
  • ZMYND2 anticorps

Protein level used designations for RUNX1T1

protein CBFA2T1 , MTG8 , MTG8/ETOb , expressed during postmitotic spinal neurons, most likely in motorneurons , acute myelogenous leukemia 1 translocation 1, cyclin-D related , core-binding factor, runt domain, alpha subunit 2; translocated to, 1; cyclin D-related , eight twenty one protein , myeloid translocation gene on 8q22 , zinc finger MYND domain-containing protein 2 , CBFA2T1 identified gene homolog , acute myelogenous leukemia 1 translocation 1 protein , core-binding factor, runt domain, alpha subunit 2 , cyclin D-related , translocated to, 1

GENE ID SPECIES
767809 Danio rerio
733153 Xenopus laevis
395503 Gallus gallus
862 Homo sapiens
487044 Canis lupus familiaris
12395 Mus musculus
362489 Rattus norvegicus
100155449 Sus scrofa
Fournisseurs de qualité sélectionnés pour anti-RUNX1T1 (RUNX1T1) Anticorps
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