anti-Runt-Related Transcription Factor 1 (RUNX1) Anticorps

Core binding factor (CBF) is a heterodimeric transcription factor that binds to the core element of many enhancers and promoters. De plus, nous expédions RUNX1 Kits (14) et RUNX1 Protéines (8) et beaucoup plus de produits pour cette protéine.

afficher tous les anticorps Gène GeneID UniProt
RUNX1 12394 Q03347
RUNX1 861 Q01196
RUNX1 50662 Q63046
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Top anti-RUNX1 Anticorps sur anticorps-enligne.fr

Showing 10 out of 279 products:

Catalogue No. Reactivité Hôte Conjugué Application Images Quantité Fournisseur Livraison Prix Détails
Boeuf (Vache) Lapin Inconjugué WB WB Suggested Anti-RUNX1 Antibody Titration: 0.2-1 ug/mlELISA Titer: 1:12500Positive Control: Jurkat cell lysate WB Suggested Anti-RUNX1  Antibody Titration: 0.2-1 µg/mL ELISA Titer: 1:12500  Positive Control: Jurkat cell lysate  RUNX1 is strongly supported by BioGPS gene expression data to be expressed in Human Jurkat cells 100 μL Connectez-vous pour afficher 6 to 8 Days
358,51 €
Détails
Boeuf (Vache) Lapin Inconjugué IHC, WB Sample Type : Mouse, post-natal day (p) 0 retinal ganglion cells Primary Antibody Dilution : 1:1500 Secondary Antibody : Donkey anti rabbit IgG Alexa 594 Secondary Antibody Dilution : 1:1000 Gene Name : RUNX1  Submitted by : Anonymous WB Suggested Anti-RUNX1 Antibody Titration: 0.2-1 ug/ml ELISA Titer: 1:12500 Positive Control: PANC1 cell lysate There is BioGPS gene expression data showing that RUNX1 is expressed in PANC1 100 μL Connectez-vous pour afficher 6 to 8 Days
358,51 €
Détails
Boeuf (Vache) Lapin Inconjugué WB WB Suggested Anti-RUNX1 Antibody Titration: 0.2-1 ug/mlELISA Titer: 1:62500Positive Control: Jurkat cell lysate WB Suggested Anti-RUNX1  Antibody Titration: 0.2-1 µg/mL ELISA Titer: 1:.2500  Positive Control: Jurkat cell lysate  RUNX1 is strongly supported by BioGPS gene expression data to be expressed in Human Jurkat cells 100 μL Connectez-vous pour afficher 6 to 8 Days
358,51 €
Détails
Boeuf (Vache) Lapin Inconjugué WB WB Suggested Anti-RUNX1 Antibody Titration: 0.2-1 ug/mlELISA Titer: 1:7812500Positive Control: Human Small Intestine 100 μL Connectez-vous pour afficher 6 to 8 Days
358,51 €
Détails
Boeuf (Vache) Lapin Inconjugué IHC, WB WB Suggested Anti-RUNX1 Antibody Titration: 0.2-1 ug/mlELISA Titer: 1:1562500Positive Control: SH-SYSY cell lysate 100 μL Connectez-vous pour afficher 6 to 8 Days
358,51 €
Détails
Boeuf (Vache) Lapin Inconjugué WB WB Suggested Anti-RUNX1 Antibody Titration: 0.2-1 ug/mlELISA Titer: 1:62500Positive Control: 721_B cell lysate 100 μL Connectez-vous pour afficher 6 to 8 Days
358,51 €
Détails
Humain Lapin Inconjugué FACS, IF, IHC (p), WB Western blot analysis of RUNX1-S276 (ABIN650732) in K562 cell line lysates (35 µg/lane). RUNX1 (arrow) was detected using the purified polyclonal antibody. Formalin-fixed and paraffin-embedded human brain tissue reacted with RUNX1 Antibody (S276) (ABIN650732), which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. 400 μL Connectez-vous pour afficher 14 to 16 Days
335,24 €
Détails
Humain Lapin Inconjugué ELISA, WB Western blot analysis of extracts from HepG2 cells treated with PMA 125ng/ml 30', using AML1 (Phospho-Ser435) Antibody. The lane on the right is treated with the synthesized peptide. 100 μg Connectez-vous pour afficher 6 to 8 Days
342,86 €
Détails
Humain Lapin Inconjugué ELISA, WB Western blot analysis of extracts from HepG2 cells, treated with PMA 125ng/ml 30', using AML1 (Ab-435) Antibody. The lane on the right is treated with the synthesized peptide. 100 μg Connectez-vous pour afficher 6 to 8 Days
342,86 €
Détails
Humain Lapin Inconjugué WB AML-1/Runx1 antibody tested by Western blot. Detection of AML-1/Runx1 by Western blot analysis. Positive detection of AML-1/Runx1 in nuclear extracts derived from Jurkat cells at 1:500 (lane 1) and 1:1,000 (lane 2) dilutions. 100 μL Connectez-vous pour afficher 1 to 3 Days
497,22 €
Détails

RUNX1 Anticorps par réactivité, application, clonalité et conjugué

Attributs Application Hôte Clonalité Conjugué
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anti-RUNX1 Anticorps mieux référencés

  1. Human Polyclonal RUNX1 Primary Antibody pour WB - ABIN2668716 : Zaidi, Dowdy, van Wijnen, Lian, Raza, Stein, Croce, Stein: Altered Runx1 subnuclear targeting enhances myeloid cell proliferation and blocks differentiation by activating a miR-24/MKP-7/MAPK network. dans Cancer research 2009 (PubMed)
    Show all 19 references for 2668716

  2. Human Polyclonal RUNX1 Primary Antibody pour FACS, IF - ABIN650732 : Moosavi, Sanchez, Adeyinka: Marker chromosomes are a significant mechanism of high-level RUNX1 gene amplification in hematologic malignancies. dans Cancer genetics and cytogenetics 2009 (PubMed)
    Show all 2 references for 650732

  3. Human Polyclonal RUNX1 Primary Antibody pour ELISA, WB - ABIN1532121 : Nucifora, Birn, Espinosa, Erickson, LeBeau, Roulston, McKeithan, Drabkin, Rowley: Involvement of the AML1 gene in the t(3,21) in therapy-related leukemia and in chronic myeloid leukemia in blast crisis. dans Blood 1993 (PubMed)

  4. Cow (Bovine) Polyclonal RUNX1 Primary Antibody pour WB - ABIN2792628 : Takeshita, Ichikawa, Nitta, Goyama, Asai, Ogawa, Chiba, Kurokawa: AML1-Evi-1 specifically transforms hematopoietic stem cells through fusion of the entire Evi-1 sequence to AML1. dans Leukemia 2008 (PubMed)

  5. Cow (Bovine) Polyclonal RUNX1 Primary Antibody pour WB - ABIN2780380 : Ghozi, Bernstein, Negreanu, Levanon, Groner: Expression of the human acute myeloid leukemia gene AML1 is regulated by two promoter regions. dans Proceedings of the National Academy of Sciences of the United States of America 1996 (PubMed)

Plus d’anticorps contre RUNX1 partenaires d’interaction

Mouse (Murine) Runt-Related Transcription Factor 1 (RUNX1) interaction partners

  1. results demonstrate that RUNX1, when uncoupled from the requirement for cooperative ETS1 binding, is sufficient to drive long-range loop formation by the enhancer Ebeta, nucleosome clearance at its target promoters, and full transcriptional activation of the TCR beta recombination center

  2. hemogenic competency in recently specified endothelial progenitors is restrained through the active silencing of Runx1 expression.

  3. Leukaemogenesis by AML1-ETO (Montrer RUNX1T1 Anticorps) requires enhanced C/D box snoRNA/RNP (Montrer RNPC3 Anticorps) formation.

  4. In this study, we found upregulation of several hemostasis-related genes, including the thrombin (Montrer F2 Anticorps)-activatable receptor PAR-1 (protease-activated receptor-1 (Montrer F2R Anticorps)), in Runx1/Cbfb (Montrer CBFB Anticorps)-deleted MLL (Montrer MLL Anticorps)-AF9 (Montrer MLLT3 Anticorps) cells. Similar to the effect of Runx1/Cbfb (Montrer CBFB Anticorps) deletion, PAR-1 (Montrer MARK2 Anticorps) overexpression induced CDKN1A/p21 (Montrer CDKN1A Anticorps) expression and attenuated proliferation in MLL (Montrer MLL Anticorps)-AF9 (Montrer MLLT3 Anticorps) cells

  5. Immunohistochemical staining for RUNX1 showed reactivity in angiogenic tufts in the retina of mice with oxygen-induced retinopathy, suggesting that RUNX1 upregulation is a hallmark of aberrant retinal angiogenesis.

  6. The Runx1-persistent group is involved in transmitting mechanical and thermal information, whereas the Runx1-transient group transmits pruriceptive information. Such hierarchical control mechanisms may provide a developmental solution for the formation of sensory circuits that transmit distinct modalities.

  7. RUNX1 was expressed in both mesenchymal and epithelial compartments of the developing and postnatal lung. Increased respiratory distress, inflammation, and proinflammatory cytokines were observed in the Runx1-deleted mice after pulmonary LPS (Montrer TLR4 Anticorps) exposure. RUNX1 deletion was associated with the activation of NF-kappaB (Montrer NFKB1 Anticorps) in respiratory epithelial cells. RUNX1 was required for the suppression of NF-kappaB (Montrer NFKB1 Anticorps) signaling pathway.

  8. both repressor and activator functions of Runx1 at multiple hematopoietic stages and lineages likely contribute to the tumor suppressor activity in MDS (Montrer MECOM Anticorps) and AML.

  9. Knock-down of PLC-gamma-1 (Montrer PLCG1 Anticorps) induced foreign body giant cell formation.PLC-gamma-1-deficiency caused a decrease in RUNX1 and subsequent PU.1 upregulation while subsequent rescue of RUNX1 in sh-PLC-gamma-1 (Montrer PLCG1 Anticorps)-transfected cells strongly inhibited foreign body giant cell formation.

  10. this study shows that distinct, asynchronous and stage-specific transcription factors (TCF-1 (Montrer HNF1A Anticorps), GATA-3 (Montrer GATA3 Anticorps) and Runx1) activate Bcl11b (Montrer BCL11B Anticorps) for T cell commitment

Human Runt-Related Transcription Factor 1 (RUNX1) interaction partners

  1. Our findings strengthen previous data concerning RUNX1 mutations in acute myeloid leukemia (Montrer BCL11A Anticorps) and support the notion that RUNX1 mutational status should be integrated into a diagnostic workup of acute myeloid leukemia (Montrer BCL11A Anticorps).

  2. Heterozygous germ line mutations in the RUNX1 gene are responsible genetic events for FPD/AML.

  3. Data suggest that RUNX1 pays dual roles in normal female sexual development/maturation and tumorigenesis in female-related cancers; "alterations" in RUNX1, either mutations in RUNX1 gene or variations in expression of RUNX1, appear to be associated with breast, ovarian, uterine, and cervical neoplasms. [REVIEW]

  4. The E3 ubiquitin ligase (Montrer MUL1 Anticorps) STUB1 (Montrer STUB1 Anticorps) is a negative regulator of both RUNX1 and RUNX1-RUNX1T1 (Montrer RUNX1T1 Anticorps). Activation of STUB1 (Montrer STUB1 Anticorps) could be a promising therapeutic strategy for RUNX1-RUNX1T1 (Montrer RUNX1T1 Anticorps) leukemia.

  5. The clinical significance of ETV6 (Montrer ETV6 Anticorps)-RUNX1.

  6. Deliver the necessary promotional drive for the progression of ETV6 (Montrer ETV6 Anticorps)-RUNX1+ pre-leukaemic cells.

  7. High RUNX1 expression is associated with pancreatic cancer.

  8. these findings have identified a novel function for Runx1 in sustaining normal mammary epithelial morphology and preventing epithelial-mesenchymal transition

  9. Leukaemogenesis by AML1-ETO (Montrer RUNX1T1 Anticorps) requires enhanced C/D box snoRNA/RNP (Montrer RNPC3 Anticorps) formation.

  10. In this study, we found upregulation of several hemostasis-related genes, including the thrombin (Montrer F2 Anticorps)-activatable receptor PAR-1 (protease-activated receptor-1 (Montrer F2R Anticorps)), in Runx1/Cbfb (Montrer CBFB Anticorps)-deleted MLL (Montrer MLL Anticorps)-AF9 (Montrer MLLT3 Anticorps) cells. Similar to the effect of Runx1/Cbfb (Montrer CBFB Anticorps) deletion, PAR-1 (Montrer MARK2 Anticorps) overexpression induced CDKN1A/p21 (Montrer CDKN1A Anticorps) expression and attenuated proliferation in MLL (Montrer MLL Anticorps)-AF9 (Montrer MLLT3 Anticorps) cells

Zebrafish Runt-Related Transcription Factor 1 (RUNX1) interaction partners

  1. Our data suggest that runx1 and cbfb are required at 2 different steps during early hematopoietic stem cell development

  2. We propose that cohesin and CTCF (Montrer CTCF Anticorps) have distinct functions in the regulation of runx1 during zebrafish embryogenesis.

  3. Morpholino knockdown of Myef2 (Montrer MYEF2 Anticorps) or Runx1 in zebrafish results in reduced numbers of hematopoietic stem cells, suggesting that these two factors also interact in vivo to regulate hematopoiesis.

  4. Runx1 is induced by high Pu.1 level and in turn transrepresses pu.1 expression, thus constituting a negative feedback loop that fashions a favorable Pu.1 level required for balanced fate commitment to neutrophils versus macrophages.

  5. hematopoietic stem cell numbers depended on activity of the transcription factor Runx1, on blood flow, and on proper development of the dorsal aorta

  6. in zebrafish adult HSCs can be formed without an intact runx1.

  7. Zebrafish embryos lacking Rad21 (Montrer RAD21 Anticorps), or cohesin subunit Smc3 (Montrer SMC3 Anticorps), fail to express runx3 (Montrer RUNX3 Anticorps) and lose hematopoietic runx1 expression in early embryonic development.

Xenopus laevis Runt-Related Transcription Factor 1 (RUNX1) interaction partners

  1. Xaml1/Runx1 is required for the specification of Rohon-Beard sensory neurons in Xenopus.

  2. ETV6-RUNX1 (TEL-AML1) fusion and hyperdiploidy (>50 chromosomes) are favorable genetic features in childhood acute lymphoblastic leukemia (ALL).

  3. reveal a shift in Runx2 (Montrer RUNX2 Anticorps) function protein during vertebrate evolution towards its exclusive roles in cartilage hypertrophy and bone differentiation within the amniote lineage

RUNX1 profil antigène

Profil protéine

Core binding factor (CBF) is a heterodimeric transcription factor that binds to the core element of many enhancers and promoters. The protein encoded by this gene represents the alpha subunit of CBF and is thought to be involved in the development of normal hematopoiesis. Chromosomal translocations involving this gene are well-documented and have been associated with several types of leukemia. Three transcript variants encoding different isoforms have been found for this gene.

Gene names and symbols associated with RUNX1

  • runt-related transcription factor 1 (RUNX1) anticorps
  • runt-related transcription factor (runt) anticorps
  • runt related transcription factor 1 (Runx1) anticorps
  • runt-related transcription factor 1 (runx1) anticorps
  • runt-related transcription factor 1 (Runx1) anticorps
  • AI462102 anticorps
  • aml anticorps
  • aml-1 anticorps
  • Aml1 anticorps
  • aml1-evi-1 anticorps
  • amlcr1 anticorps
  • cbfa2 anticorps
  • evi-1 anticorps
  • Pebp2a2 anticorps
  • pebp2ab anticorps
  • Pebpa2b anticorps
  • Runx-1 anticorps
  • runx1 anticorps
  • runxa anticorps
  • XAML anticorps
  • Xaml1 anticorps

Protein level used designations for RUNX1

runt-related transcription factor 1 , runt-related transcription factor 1 (acute myeloid leukemia 1; aml1 oncogene) , runt-related transcription factor , runt protein , CBF-alpha-2 , PEA2-alpha B , PEBP2-alpha B , SL3-3 enhancer factor 1 alpha B subunit , SL3/AKV core-binding factor alpha B subunit , acute myeloid leukemia 1 protein , core binding factor alpha 2 , core-binding factor subunit alpha-2 , oncogene AML-1 , polyomavirus enhancer-binding protein 2 alpha B subunit , runt domain, alpha subunit 2 , AML1-EVI-1 fusion protein , core-binding factor, runt domain, alpha subunit 2 , aml1 , runt-related transcription factor a , runx1a , Acute myeloid leukemia 1 protein , Core-binding factor subunit alpha-2 , aml1 oncogene , ch-runtB2 , acute myeloid leukemia 1 , factor, runt domain, alpha subunit 2 , core-binding factor runt domain alpha subunit 2 (acute myeloid leukemia 1 oncogene) , runt related transcription factor 1

GENE ID SPECIES
473981 Pan troglodytes
100302713 Saccoglossus kowalevskii
12394 Mus musculus
861 Homo sapiens
58126 Danio rerio
379657 Xenopus laevis
396152 Gallus gallus
487746 Canis lupus familiaris
529631 Bos taurus
50662 Rattus norvegicus
100512633 Sus scrofa
100724149 Cavia porcellus
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