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Core binding factor (CBF) is a heterodimeric transcription factor that binds to the core element of many enhancers and promoters. De plus, nous expédions RUNX1 Kits (14) et RUNX1 Protéines (8) et beaucoup plus de produits pour cette protéine.
Showing 10 out of 271 products:
Human Polyclonal RUNX1 Primary Antibody pour EIA, WB - ABIN500646
Lee, Jenner, Boyer, Guenther, Levine, Kumar, Chevalier, Johnstone, Cole, Isono, Koseki, Fuchikami, Abe, Murray, Zucker, Yuan, Bell, Herbolsheimer, Hannett, Sun, Odom, Otte, Volkert, Bartel, Melton, Gifford, Jaenisch, Young: Control of developmental regulators by Polycomb in human embryonic stem cells. dans Cell 2006
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Human Polyclonal RUNX1 Primary Antibody pour FACS, IF - ABIN650732
Moosavi, Sanchez, Adeyinka: Marker chromosomes are a significant mechanism of high-level RUNX1 gene amplification in hematologic malignancies. dans Cancer genetics and cytogenetics 2009
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Cow (Bovine) Polyclonal RUNX1 Primary Antibody pour WB - ABIN2792567
Takeshita, Ichikawa, Nitta, Goyama, Asai, Ogawa, Chiba, Kurokawa: AML1-Evi-1 specifically transforms hematopoietic stem cells through fusion of the entire Evi-1 sequence to AML1. dans Leukemia 2008
Human Polyclonal RUNX1 Primary Antibody pour ELISA, WB - ABIN1532121
Nucifora, Birn, Espinosa, Erickson, LeBeau, Roulston, McKeithan, Drabkin, Rowley: Involvement of the AML1 gene in the t(3,21) in therapy-related leukemia and in chronic myeloid leukemia in blast crisis. dans Blood 1993
Chicken Polyclonal RUNX1 Primary Antibody pour WB - ABIN2780380
Ghozi, Bernstein, Negreanu, Levanon, Groner: Expression of the human acute myeloid leukemia gene AML1 is regulated by two promoter regions. dans Proceedings of the National Academy of Sciences of the United States of America 1996
the Acute Myeloid Leukemia-1a (AML-1a) transcription factor, a regulator of immune gene expression, was identified as potentially sensitive to nucleosomal regulation within the Ly49 gene family. This result was confirmed in RMA, a cell line with natural expression of Ly49, using MNase-Seq to generate a nucleosome map of chromosome 6, where the Ly49 gene family is located
Data show that immature Runx1-deficient CD4 (Montrer CD4 Anticorps)(+) T cells are eliminated in the periphery by the activation and fixation of the classical complement pathway.
Runx1 deficiency enhanced CGRP expression and disrupted BMP4-induced neurite outgrowth inhibition in DRG.
Runx1 could be manipulated after injury to promote neuronal differentiation to facilitate repair of the CNS.
Runx1 haploinsufficiency appears to predispose FPD patients to MM by expanding the pool of stem/progenitor cells and blocking myeloid differentiation in response to G-CSF (Montrer CSF3 Anticorps).
Runx1 has an important role in Nf1 (Montrer NF1 Anticorps) neurofibroma initiation
RUNX1 and ER occupy adjacent elements in AXIN1 (Montrer AXIN1 Anticorps)'s second intron, and RUNX1 antagonizes oestrogen-mediated AXIN1 (Montrer AXIN1 Anticorps) suppression.
A high level of Runx1 mRNA expression was detected on days 6-8 of pregnancy and under artificial decidualization. Data suggest that Runx1 may play an important role during mouse decidualization.
Results suggest that Runx1 is involved in targeting ventrocaudal hypoglossal neurons to specific muscles but is not necessary for neuronal survival, motoneuron specification, or synaptic development
Setbp1 (Montrer SETBP1 Anticorps) overexpression also causes transcriptional repression of critical hematopoiesis regulator gene Runx1
In the PPI network, genes may be involved in Down syndrome (DS) by interacting with others, including nuclear receptor subfamily 4 group A member 2 (NR4A2 (Montrer NR4A2 Anticorps))early growth response (EGR)2 (Montrer EGR2 Anticorps) and NR4A2EGR3. Therefore, RUNX1, NR4A2 (Montrer NR4A2 Anticorps), EGR2 (Montrer EGR2 Anticorps), EGR3 (Montrer EGR3 Anticorps) and ID4 (Montrer ID4 Anticorps) may be key genes associated with the pathogenesis of DS.
Study shows that AML1 gene overexpression characterizes a broader range of leukemic subtypes than previously thought, including various maturation stages of B-cell acute lymphoblastic leukemia and cytogenetic types additional to those involving the AML1 gene.
the effects of various aberrations in ETV6 (Montrer ETV6 Anticorps) and RUNX1 gene copy number on disease prognosis were evaluated in 21 pediatric patients diagnosed with B-cell ALL with/without t(12;21).
The RUNX1 fusion transcript encodes a truncated protein containing the Runt homology domain responsible for both heterodimerization with CBFB (Montrer CBFB Anticorps) and DNA binding, but lacking the proline-, serine-, and threonine-rich (PST (Montrer SULT1A1 Anticorps)) region which is the transcription activation domain at the C terminal end
novel RUNX1 isoforms contribute in controlling CD56 (Montrer NCAM1 Anticorps) expression in acute myeloid leukemia (Montrer BCL11A Anticorps) cells.
this paper shows that RUNX1 is associated with the pathogenesis of immune thrombocytopenia possibly through regulation of Th17 cell differentiation
We show that RUNX1 P1 expression is associated with colon cancer free survival suggesting a role for RUNX1 in aspirin's protective effect in colon cancer. Our studies reveal an effect of aspirin on RUNX1 and gene expression that may additionally explain aspirin's effects in cardiovascular disease and cancer.
we identified rs2249650 and rs2268276 as new AML susceptibility-associated SNPs. Genome editing at rs2249650 and rs2268276 may be performed in future to uncover the effect of this potential RUNX1 enhancer region.
RUNX1 and FKBP7 (Montrer FKBP7 Anticorps), involved in erythropoesis and muscle protein synthesis, respectively, are related to change in cardiorespiratory fitness in response to exercise.
HTLF (Montrer FOXN2 Anticorps) is a RUNX1 target whose down-regulation promotes genomic instability and correlates with complex cytogenetic abnormalities in acute myeloid leukemia (Montrer BCL11A Anticorps) patients.
Our data suggest that runx1 and cbfb are required at 2 different steps during early hematopoietic stem cell development
We propose that cohesin and CTCF (Montrer CTCF Anticorps) have distinct functions in the regulation of runx1 during zebrafish embryogenesis.
Morpholino knockdown of Myef2 (Montrer MYEF2 Anticorps) or Runx1 in zebrafish results in reduced numbers of hematopoietic stem cells, suggesting that these two factors also interact in vivo to regulate hematopoiesis.
Runx1 is induced by high Pu.1 level and in turn transrepresses pu.1 expression, thus constituting a negative feedback loop that fashions a favorable Pu.1 level required for balanced fate commitment to neutrophils versus macrophages.
hematopoietic stem cell numbers depended on activity of the transcription factor Runx1, on blood flow, and on proper development of the dorsal aorta
in zebrafish adult HSCs can be formed without an intact runx1.
Zebrafish embryos lacking Rad21 (Montrer RAD21 Anticorps), or cohesin subunit Smc3 (Montrer SMC3 Anticorps), fail to express runx3 (Montrer RUNX3 Anticorps) and lose hematopoietic runx1 expression in early embryonic development.
Xaml1/Runx1 is required for the specification of Rohon-Beard sensory neurons in Xenopus.
ETV6-RUNX1 (TEL-AML1) fusion and hyperdiploidy (>50 chromosomes) are favorable genetic features in childhood acute lymphoblastic leukemia (ALL).
reveal a shift in Runx2 (Montrer RUNX2 Anticorps) function protein during vertebrate evolution towards its exclusive roles in cartilage hypertrophy and bone differentiation within the amniote lineage
Core binding factor (CBF) is a heterodimeric transcription factor that binds to the core element of many enhancers and promoters. The protein encoded by this gene represents the alpha subunit of CBF and is thought to be involved in the development of normal hematopoiesis. Chromosomal translocations involving this gene are well-documented and have been associated with several types of leukemia. Three transcript variants encoding different isoforms have been found for this gene.
runt-related transcription factor 1
, runt-related transcription factor 1 (acute myeloid leukemia 1; aml1 oncogene)
, runt-related transcription factor
, runt protein
, PEA2-alpha B
, PEBP2-alpha B
, SL3-3 enhancer factor 1 alpha B subunit
, SL3/AKV core-binding factor alpha B subunit
, acute myeloid leukemia 1 protein
, core binding factor alpha 2
, core-binding factor subunit alpha-2
, oncogene AML-1
, polyomavirus enhancer-binding protein 2 alpha B subunit
, runt domain, alpha subunit 2
, AML1-EVI-1 fusion protein
, core-binding factor, runt domain, alpha subunit 2
, runt-related transcription factor a
, Acute myeloid leukemia 1 protein
, Core-binding factor subunit alpha-2
, aml1 oncogene
, acute myeloid leukemia 1
, factor, runt domain, alpha subunit 2
, core-binding factor runt domain alpha subunit 2 (acute myeloid leukemia 1 oncogene)
, runt related transcription factor 1