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Polyamines are ubiquitous polycationic alkylamines which include spermine, spermidine, putrescine, and agmatine. De plus, nous expédions Spermine Oxidase Kits (10) et Spermine Oxidase Protéines (7) et beaucoup plus de produits pour cette protéine.
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A novel enzyme with spermine oxidase properties in bovine liver mitochondria has been isolated and characterized.
AtPAO1 is the first plant Polyamine oxidase (Montrer PAOX Anticorps) reported to be involved in a polyamine back-conversion pathway.
effect of Tat (Montrer TAT Anticorps) on Nrf2 (Montrer GABPA Anticorps) activation in human neuroblastoma (Montrer ARHGEF16 Anticorps) cells and the role of NMDA receptor and spermine oxidase on Tat (Montrer TAT Anticorps)-induced nuclear factor erythroid 2-related factor 2 (Nrf2 (Montrer NFE2L2 Anticorps)) activation
During H. pylori infection, the enzyme spermine oxidase (SMOX) is induced, which generates hydrogen peroxide from the catabolism of the polyamine spermine, and increases gastric cancer risk.
study postulates a mechanism for SAT1 (Montrer SAT1 Anticorps) and SMOX down-regulation by post-transcriptional activity of miRNAs.
Tat (Montrer TAT Anticorps) was found to induce reactive oxygen species production and to affect cell viability in SH-SY5Y cells, these effects being mediated by spermine oxidase (SMO)
Spermine oxidase mediates the gastric cancer risk associated with Helicobacter pylori CagA (Montrer S100A8 Anticorps).
each gene was associated with at least one main outcome: anxiety (SAT1 (Montrer SAT1 Anticorps), SMS (Montrer SMS Anticorps)), mood disorders (SAT1 (Montrer SAT1 Anticorps), SMOX), and suicide attempts (SAT1 (Montrer SAT1 Anticorps), OATL1 (Montrer TBC1D25 Anticorps)).
Spermine oxidase (SMO) has a role in response to BENSpm and CPENSpm in breast tumor cells
Increased expression of spermine oxidase is associated with ulcerative colitis.
the genetic and epigenetic factors examined in this study show little influence on the expression level of SMOX in suicide completers.
Knockdown studies suggest that induction of SSAT (Montrer SAT1 Anticorps) and SMO is correlated with the antiproliferative effects of BENSpm with 5-FU or paclitaxel in MDA-MB-231 cells.
Spermine oxidase is an important regulator of muscle gene expression and fiber size.
Data (including data from studies using recombinant mutant proteins) suggest that Glu216-Ser218 is a hot spot responsible for Smox substrate specificity; Smox with mutation E216L/S218A exhibits specificity for N'-acetylspermine rather than spermine.
ROS (Montrer ROS1 Anticorps) overexposure by mSMOX delivers an earlier adaptive response to radiation
Spermine oxidase binds spermine in a similar conformation as that observed in the yeast polyamine oxidase (Montrer PAOX Anticorps) FMS1-spermine complex and demonstrate a major role for residues His82 and Lys367 in substrate binding and catalysis.
expression and characterization of mouse spermine oxidase
we identified a second domain that is necessary for nuclear localization of the spermine oxidase splice variant
Polyamines are ubiquitous polycationic alkylamines which include spermine, spermidine, putrescine, and agmatine. These molecules participate in a broad range of cellular functions which include cell cycle modulation, scavenging reactive oxygen species, and the control of gene expression. These molecules also play important roles in neurotransmission through their regulation of cell-surface receptor activity, involvement in intracellular signalling pathways, and their putative roles as neurotransmitters. This gene encodes an FAD-containing enzyme that catalyzes the oxidation of spermine to spermadine and secondarily produces hydrogen peroxide. Multiple transcript variants encoding different isoenzymes have been identified for this gene, some of which have failed to demonstrate significant oxidase activity on natural polyamine substrates. The characterized isoenzymes have distinctive biochemical characteristics and substrate specificities, suggesting the existence of additional levels of complexity in polyamine catabolism.
, flavin containing amine oxidase
, flavin-containing spermine oxidase
, polyamine oxidase 1
, putative cyclin G1 interacting protein