ATF2 anticorps (Activating Transcription Factor 2) (pSer480) (HRP)

Details for Product anti-ATF2 Antibody No. ABIN1712621, Fournisseur: Connectez-vous pour afficher
Antigène
  • CHN1
  • CG12850
  • CG3749
  • dATF-2
  • DmelCG30420
  • CG30420
  • CRE-BP1
  • CREB2
  • HB16
  • TREB7
  • Atf-2
  • CRE-BP
  • Creb2
  • D130078H02Rik
  • D18875
  • Tg(Gzma-Klra1)7Wum
  • mXBP
  • atf2-A
  • atf2l
  • ATF1
  • ATF2
  • HFB1-GDNF
  • HSCR3
  • activating transcription factor 2
  • Activating transcription factor-2
  • glial cell derived neurotrophic factor
  • ATF2
  • Atf-2
  • Atf2
  • atf2
  • LOC100355367
  • GDNF
Alternatives
anti-Souris ATF2 anticorps pour ELISA
Épitope
pSer480
76
50
43
37
36
36
35
33
31
30
28
25
22
18
15
14
12
11
11
10
10
8
7
6
6
6
6
5
4
4
3
3
3
3
3
3
3
2
2
2
2
2
2
2
2
2
2
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
Reactivité
Humain, Souris
644
401
362
30
21
14
14
12
10
8
5
5
2
2
2
2
1
1
Hôte
Lapin
567
56
19
4
Clonalité
Polyclonal
Conjugué
Cet anticorp ATF2 est conjugé à/à la HRP
15
15
15
10
10
9
9
9
9
9
9
9
9
9
7
6
6
1
1
1
1
1
1
1
1
1
1
1
Application
Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Western Blotting (WB)
442
244
157
131
118
99
83
22
21
11
8
6
6
3
2
2
1
1
Options
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Immunogène KLH conjugated synthetic phosphopeptide derived from mouse ATF2 around the phosphorylation site of Ser480
Isotype IgG
Purification Purified by Protein A.
Autre désignation Atf2 (ATF2 Antibody Extrait)
Sujet

ATF2 is a member of the ATF/CREB family of basic region leucine zipper DNA binding proteins that regulates transcription by binding to a consensus cAMP response element (CRE) in the promoter of various viral and cellular genes. Many of these genes are important in cell growth and differentiation, and in stress and immune responses. ATF2 is a nuclear protein that binds DNA as a dimer and can form dimers with members of the ATF/CREB and Jun/Fos families. It is a stronger activator as a heterodimer with cJun than as a homodimer. Several isoforms of ATF2 arise by differential splicing. The stable native full length ATF2 is transcriptionally inactive as a result of an inhibitory direct intramolecular interaction of its carboxy terminal DNA binding domain with the amino terminal transactivation domain. Following dimerization ATF2 becomes a short lived protein that undergoes ubiquitination and proteolysis, seemingly in a protein phosphatase-dependent mechanism. Stimulation of the transcriptional activity of ATF2 occurs following cellular stress induced by several genotoxic agents, inflammatory cytokines, and UV irradiation. This activation requires phosphorylation of two threonine residues in ATF2 by both JNK/SAP kinase and p38 MAP kinase. ATF2 is abundantly expressed in brain.

Synonyms: ATF2 phospho S480, p-ATF2 phospho S480, p-ATF2 phospho Ser480, ATF2Ser480, CREB 2, HB 16, Activating Transcription Factor 2, ATF 2, Atf-2, ATF2 protein, cAMP Response Element Binding Protein 2, cAMP response element binding protein CRE BP1, cAMP-dependent transcription factor ATF-2, cAMP-responsive element-binding protein 2, CRE BP1, CRE-BP, CREB 2, CREB2, CREBP1, Cyclic AMP dependent transcription factor ATF 2, Cyclic AMP-responsive, ATF2_HUMAN.

ID gène 11909
Domaine de recherche Immunology, Innate Immunity, Transcription Factors
Pathways Signalisation MAPK, Signalisation RTK, Thyroid Hormone Synthesis, Activation of Innate immune Response, Chromatin Binding, Myometrial Relaxation and Contraction, Synaptic Membrane, Tube Formation, Toll-Like Receptors Cascades
Indications d'application WB 1:100-1000
IHC-P 1:100-500
Restrictions For Research Use only
Format Liquid
Concentration 1 μg/μL
Buffer Aqueous buffered solution containing 1 % BSA, 50 % glycerol and 0.09 % Gentamicin.
Agent conservateur Gentamicin sulfate
Précaution d'utilisation This product contains Gentamicin sulfate: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Conseil sur la manipulation Do NOT add Sodium Azide! Use of Sodium Azide will inhibit enzyme activity of horseradish peroxidase.
Stock 4 °C
Stockage commentaire Store at 4°C
Date de péremption 12 months