TRADD anticorps (Middle Region)
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- Antigène Voir toutes TRADD Anticorps
- TRADD (TNFRSF1A-Associated Via Death Domain (TRADD))
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Épitope
- Middle Region
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Reactivité
- Humain, Chien, Cheval
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Hôte
- Lapin
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Clonalité
- Polyclonal
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Conjugué
- Cet anticorp TRADD est non-conjugé
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Application
- Western Blotting (WB)
- Séquence
- YEQAFQLLRR FVQAEGRRAT LQRLVEALEE NELTSLAEDL LGLTDPNGGL
- Homologie
- Dog: 76%, Horse: 76%, Human: 100%
- Attributs du produit
- This is a rabbit polyclonal antibody against TRADD. It was validated on Western Blot using a cell lysate as a positive control.
- Purification
- Affinity Purified
- Immunogène
- The immunogen is a synthetic peptide directed towards the middle region of human TRADD
- Top Product
- Discover our top product TRADD Anticorps primaire
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- Indications d'application
- Optimal working dilutions should be determined experimentally by the investigator.
- Commentaires
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Antigen size: 312 AA
- Restrictions
- For Research Use only
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- Format
- Liquid
- Concentration
- Lot specific
- Buffer
- Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.
- Agent conservateur
- Sodium azide
- Précaution d'utilisation
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Conseil sur la manipulation
- Avoid repeated freeze-thaw cycles.
- Stock
- -20 °C
- Stockage commentaire
- For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.
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- Antigène
- TRADD (TNFRSF1A-Associated Via Death Domain (TRADD))
- Autre désignation
- TRADD (TRADD Produits)
- Synonymes
- anticorps TRADD, anticorps Hs.89862, anticorps 9130005N23Rik, anticorps AA930854, anticorps wu:fc59e02, anticorps zgc:103556, anticorps tradd, anticorps TNFRSF1A associated via death domain, anticorps conjugal transfer protein D, anticorps TNFRSF1A-associated via death domain, anticorps TNFRSF1A-associated via death domain L homeolog, anticorps tnfrsf1a-associated via death domain, anticorps TRADD, anticorps traDd, anticorps Tradd, anticorps tradd.L, anticorps tradd
- Sujet
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TRADD is the adapter molecule for TNFRSF1A/TNFR1 that specifically associates with the cytoplasmic domain of activated TNFRSF1A/TNFR1 mediating its interaction with FADD. Overexpression of TRADD leads to two major TNF-induced responses, apoptosis and activation of NF-kappa-B.The protein encoded by this gene is a death domain containing adaptor molecule that interacts with TNFRSF1A/TNFR1 and mediates programmed cell death signaling and NF-kappaB activation. This protein binds adaptor protein TRAF2, reduces the recruitment of inhibitor-of-apoptosis proteins (IAPs) by TRAF2, and thus suppresses TRAF2 mediated apoptosis. This protein can also interact with receptor TNFRSF6/FAS and adaptor protein FADD/MORT1, and is involved in the Fas-induced cell death pathway. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Entrez Gene record to access additional publications.
Alias Symbols: Hs.89862, MGC11078
Protein Interaction Partner: FADD, UBC, TNF, RIPK1, TNFRSF1A, ZMYND11, TOMM70A, PDLIM7, LRRK2, OPTN, TRADD, TRAF2, TRAF1, TNFRSF1B, GFRA1, CHUK, FAS, DAB2IP, EDAR, CDKN2A, TRIP12, LMP1, CASP8, SH3KBP1, USP2, TNFRSF25, PPP2R1A, TRPC4AP, HIPK2, TNFRSF21, CNTRL, TNFRSF10B, TNFRSF10A, BC
Protein Size: 312 - Poids moléculaire
- 34 kDa
- ID gène
- 8717
- NCBI Accession
- NM_003789, NP_003780
- UniProt
- Q15628
- Pathways
- Signalisation NF-kappaB, Apoptose, Caspase Cascade in Apoptosis, Positive Regulation of Endopeptidase Activity, Hepatitis C
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