Rhodopsin anticorps (C-Term)
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- Antigène Voir toutes Rhodopsin (RHO) Anticorps
- Rhodopsin (RHO)
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Épitope
- C-Term
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Reactivité
- Humain
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Hôte
- Lapin
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Clonalité
- Polyclonal
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Conjugué
- Cet anticorp Rhodopsin est non-conjugé
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Application
- Western Blotting (WB), Immunohistochemistry (IHC)
- Specificité
- Specific for Rhodopsin.
- Immunogène
- A synthetic peptide from c-terminal region of human Rhodopsin (OPSD, Opsin-2) conjugated to an immunogenic carrier protein was used as the antigen. The antigen is homologous in mouse and rat.
- Isotype
- IgG
- Top Product
- Discover our top product RHO Anticorps primaire
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- Indications d'application
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A concentration of 10-50 µg/ml is recommended.
The optimal concentration should be determined by the end user.
Not yet tested in other applications. - Restrictions
- For Research Use only
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- Format
- Lyophilized
- Reconstitution
- Reconstitute in 500 µL of sterile water. Centrifuge to remove any insoluble material.
- Conseil sur la manipulation
- Avoid freeze and thaw cycles.
- Stock
- 4 °C/-20 °C
- Stockage commentaire
- Maintain the lyophilised/reconstituted antibodies frozen at -20°C for long term storage and refrigerated at 2-8°C for a shorter term. When reconstituting, glycerol (1:1) may be added for an additional stability. Avoid freeze and thaw cycles.
- Date de péremption
- 12 months
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- Antigène
- Rhodopsin (RHO)
- Autre désignation
- Rhodopsin (RHO Produits)
- Synonymes
- anticorps CSNBAD1, anticorps OPN2, anticorps RP4, anticorps RH1, anticorps Rh, anticorps fi06d11, anticorps wu:fi06d11, anticorps zfo2, anticorps zfrho, anticorps Noerg1, anticorps Opn2, anticorps Ops, anticorps opn2, anticorps rh1, anticorps rp4, anticorps xrho, anticorps PIGRHO1, anticorps ops, anticorps RDP1, anticorps RHO, anticorps rhodopsin, anticorps rhodopsin L homeolog, anticorps RHO, anticorps Rho, anticorps rho, anticorps rho.L
- Classe de substances
- Chemical
- Sujet
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Function: Photoreceptor required for image-forming vision at low light intensity. Required for photoreceptor cell viability after birth. Light-induced isomerization of 11-cis to all-trans retinal triggers a conformational change leading to G-protein activation and release of all-trans retinal. BIOPHYSICOCHEMICAL PROPERTIES: Absorption: Abs(max)=495 nm,
Subcellular location: Membrane, Multi-pass membrane protein.
Tissue specificity: Rod shaped photoreceptor cells which mediates vision in dim light. PTM: Phosphorylated on some or all of the serine and threonine residues present in the C-terminal region. DISEASE: Defects in RHO are the cause of retinitis pigmentosa type 4 (RP4). RP leads to degeneration of retinal photoreceptor cells. Patients typically have night vision blindness and loss of midperipheral visual field. As their condition progresses, they lose their far peripheral visual field and eventually central vision as well. RP4 inheritance is autosomal dominant. DISEASE: Defects in RHO are a cause of retinitis pigmentosa autosomal recessive (ARRP). DISEASE: Defects in RHO are a cause of autosomal dominant congenital stationary night blindness 1 (CSNBAD1), also known as rhodopsin-related congenital stationary night blindness. Congenital stationary night blindness is a nonprogressive retinal disorder characterized by impaired night vision and ocular symptoms such as myopia, hyperopia, nystagmus and reduced visual acuity. Also known as: Rhodopsin, opsin-2, RHO, OPN2, RP4, MGC138309, MGC138311. - Pathways
- Signalisation WNT, Sensory Perception of Sound, Regulation of G-Protein Coupled Receptor Protein Signaling, Phototransduction
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