TBK1 anticorps (pSer172)
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- Antigène Voir toutes TBK1 Anticorps
- TBK1 (TANK-Binding Kinase 1 (TBK1))
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Épitope
- pSer172
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Reactivité
- Humain, Souris
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Hôte
- Souris
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Clonalité
- Monoclonal
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Conjugué
- Cet anticorp TBK1 est non-conjugé
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Application
- Western Blotting (WB)
- Marque
- BD Pharmingen™
- Réactivité croisée (Details)
- Predicted: Mouse
- Attributs du produit
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1. Since applications vary, each investigator should titrate the reagent to obtain optimal results.
2. Please refer to us for technical protocols.
3. Caution: Sodium azide yields highly toxic hydrazoic acid under acidic conditions. Dilute azide compounds in running water before discarding to avoid accumulation of potentially explosive deposits in plumbing. - Purification
- The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography.
- Immunogène
- Phosphorylated Human TBK1
- Clone
- J133-1171
- Isotype
- IgG2b kappa
- Top Product
- Discover our top product TBK1 Anticorps primaire
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- Restrictions
- For Research Use only
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- Format
- Liquid
- Concentration
- 0.5 mg/mL
- Buffer
- Aqueous buffered solution containing ≤0.09 % sodium azide.
- Agent conservateur
- Sodium azide
- Précaution d'utilisation
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Stock
- 4 °C
- Stockage commentaire
- Store undiluted at 4°C.
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Phosphorylation of NF-kappaB and IkappaB proteins: implications in cancer and inflammation." dans: Trends in biochemical sciences, Vol. 30, Issue 1, pp. 43-52, (2005) (PubMed).
: "IKK-i and TBK-1 are enzymatically distinct from the homologous enzyme IKK-2: comparative analysis of recombinant human IKK-i, TBK-1, and IKK-2." dans: The Journal of biological chemistry, Vol. 277, Issue 16, pp. 13840-7, (2002) (PubMed).
: "
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Phosphorylation of NF-kappaB and IkappaB proteins: implications in cancer and inflammation." dans: Trends in biochemical sciences, Vol. 30, Issue 1, pp. 43-52, (2005) (PubMed).
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- Antigène
- TBK1 (TANK-Binding Kinase 1 (TBK1))
- Autre désignation
- TBK1 (TBK1 Produits)
- Synonymes
- anticorps nak, anticorps t2k, anticorps TBK1, anticorps wu:fk70c05, anticorps zgc:136548, anticorps NAK, anticorps T2K, anticorps 1200008B05Rik, anticorps AI462036, anticorps AW048562, anticorps TANK binding kinase 1 L homeolog, anticorps TANK binding kinase 1, anticorps TANK-binding kinase 1, anticorps tbk1.L, anticorps TBK1, anticorps tbk1, anticorps Tbk1
- Sujet
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NF-kB is a ubiquitously expressed transcription factor that regulates many cytokine and Ig genes. It is involved in immune, inflammatory, viral, and acute phase responses. In most cells, NF-kB is sequestered in an inactive cytoplasmic form via interactions with the inhibitory proteins IkBalpha, IkBbeta, and IkBepsilon. Stimulation induces the release, activation, and nuclear translocation of NF-kB. Release of NF-kB results from the phosphorylation and proteolytic degradation of the IkB proteins. Two cytokine-inducible IkappaB kinases (IKKa and IKKb) phosphorylate and target the IkB proteins for degradation via the ubiquitin pathway. IKKg/NEMO, a third member of the IKK complex, functions as a regulatory subunit and interacts directly with IKKb. TBK1 (TANK-binding kinase 1, also known as T2K or NAK), a protein of 729 amino acids, is another member of the IKK family of kinases regulating NF-kB downstream of the tumor necrosis factor and Toll-like receptor pathways. TBK1 forms a complex with the adaptor proteins TANK (TRAF-associated NF-kB activator) and TRAF2 (TNF-receptor-associated factor 2), and this oligomer is required for activation and phosphorylation of TBK1 at serine 172 (S172).
The J133-1171 monoclonal antibody recognizes the phosphorylated S172 of human TBK1.
Synonyms: T2K, NAK - Poids moléculaire
- 80 kDa
- Pathways
- Signalisation TLR, Activation of Innate immune Response, Hepatitis C, Toll-Like Receptors Cascades, SARS-CoV-2 Protein Interactome
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