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MSH3 anticorps (AA 136-349)

MSH3 Reactivité: Humain WB, IF Hôte: Souris Monoclonal 52-MSH3 unconjugated
N° du produit ABIN968513
  • Antigène Voir toutes MSH3 Anticorps
    MSH3 (MutS Homolog 3 (MSH3))
    Épitope
    • 15
    • 6
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 136-349
    Reactivité
    • 29
    • 3
    • 2
    Humain
    Hôte
    • 29
    Souris
    Clonalité
    • 28
    • 1
    Monoclonal
    Conjugué
    • 15
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Cet anticorp MSH3 est non-conjugé
    Application
    • 13
    • 13
    • 13
    • 9
    • 7
    • 4
    • 4
    • 4
    • 4
    • 2
    Western Blotting (WB), Immunofluorescence (IF)
    Attributs du produit
    1. Since applications vary, each investigator should titrate the reagent to obtain optimal results.
    2. Source of all serum proteins is from USDA inspected abattoirs located in the United States.
    3. Caution: Sodium azide yields highly toxic hydrazoic acid under acidic conditions. Dilute azide compounds in running water before discarding to avoid accumulation of potentially explosive deposits in plumbing.
    4. Please refer to us for technical protocols.
    Purification
    The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography.
    Immunogène
    Human MSH3 aa. 136-349
    Clone
    52-MSH3
    Isotype
    IgG1
    Top Product
    Discover our top product MSH3 Anticorps primaire
  • Commentaires

    Related Products: ABIN967389, ABIN968535

    Restrictions
    For Research Use only
  • Format
    Liquid
    Concentration
    250 μg/mL
    Buffer
    Aqueous buffered solution containing BSA, glycerol, and ≤0.09 % sodium azide.
    Agent conservateur
    Sodium azide
    Précaution d'utilisation
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Stock
    -20 °C
    Stockage commentaire
    Store undiluted at -20°C.
  • Wilson, Guerrette, Fishel: "Dissociation of mismatch recognition and ATPase activity by hMSH2-hMSH3." dans: The Journal of biological chemistry, Vol. 274, Issue 31, pp. 21659-64, (1999) (PubMed).

    Umar, Risinger, Glaab, Tindall, Barrett, Kunkel: "Functional overlap in mismatch repair by human MSH3 and MSH6." dans: Genetics, Vol. 148, Issue 4, pp. 1637-46, (1998) (PubMed).

    Watanabe, Ikejima, Suzuki, Shimada: "Genomic organization and expression of the human MSH3 gene." dans: Genomics, Vol. 31, Issue 3, pp. 311-8, (1997) (PubMed).

    New, Liu, Crouse: "The yeast gene MSH3 defines a new class of eukaryotic MutS homologues." dans: Molecular & general genetics : MGG, Vol. 239, Issue 1-2, pp. 97-108, (1993) (PubMed).

  • Antigène
    MSH3 (MutS Homolog 3 (MSH3))
    Autre désignation
    MSH3 (MSH3 Produits)
    Synonymes
    anticorps ATMSH3, anticorps M7J2.90, anticorps M7J2_90, anticorps homolog of DNA mismatch repair protein MSH3, anticorps DUP, anticorps MRP1, anticorps D13Em1, anticorps Rep-3, anticorps Rep3, anticorps mutS homolog 3, anticorps DNA mismatch repair protein MSH3, anticorps homolog of DNA mismatch repair protein MSH3, anticorps mismatch repair protein, anticorps MSH3, anticorps Msh3
    Sujet
    Bacterial mismatch DNA repair involves the MutL, MutH, and MutS proteins, which forms a complex that mediates excision repair. Mutations in or deficiencies of any of these proteins results in a mutator phenotype that is characterized by genetic instability. Human homologs of MutS include MSH2, MSH3, and MSH6. MSH2 forms heterodimers with MSH6 (hMutSalpha) or MSH3 (hMutSbeta) that specifically bind single-mispaired nucleotides and a subset of insertion-deletion mismatches. In addition, these heterodimers have intrinsic ATPase activity that is regulated by mismatch binding. ADP-bound heterodimers bind mismatched nucleotides, while ATP-bound heterodimers do not. The role of MSH3 in genetic stability in human cells in unclear. However, MSH3 and MSH6 share roles in the control of mutation rates. Both participate in repair of replication errors containing base-base mismatches or 1-4 extra bases. The MSH3 gene is located upstream of the dihydrofolate reductase (DHFR) gene and is expressed at low levels in a variety of human tissues. Thus, MSH3 is a component of an adenosine nucleotide-regulated molecular switch whose activity is essential for classical nucleotide mismatch repair.
    Poids moléculaire
    127 kDa
    Pathways
    Réparation de l'ADN, Production of Molecular Mediator of Immune Response
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