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NKp65 utilizes a hemi-immunoreceptor tyrosine-based activation motif -like motif for cellular activation that requires Syk, although Syk appears not to be recruited to NKp65.
Syk is a key regulator of Hoxa9 (Montrer HOXA9 Kits ELISA)/Meis1 (Montrer MEIS1 Kits ELISA)-driven acute myeloid leukemia (Montrer BCL11A Kits ELISA).
Data show that spleen tyrosine kinase (SYK) and proto-oncogene (Montrer RAB1A Kits ELISA) protein c (Montrer PROC Kits ELISA)-akt (AKT1 (Montrer AKT1 Kits ELISA)) proteins were increased in the cytoplasm of the cells forming Mallory-Denk bodies.
B cell receptor signaling component, SYK, caused PAX5 (Montrer PAX5 Kits ELISA) tyrosine phosphorylation in vitro and in cells. Transcriptional repression on the BLIMP1 (Montrer PRDM1 Kits ELISA) promoter by PAX5 (Montrer PAX5 Kits ELISA) was attenuated by this phosphorylation.
Pharmacological inhibitors of SYK activity significantly reduced the engulfment of oxLDL microbeads in the presence of serum factors, but had little effect on IgG phagocytosis.
our data strongly suggest that AQCA-mediated suppression of inflammatory responses could be managed by a direct interference of signaling cascades including IRAK (Montrer IRAK1 Kits ELISA) and Syk, linked to the activation of NF-kappaB (Montrer NFKB1 Kits ELISA) and AP-1 (Montrer FOSB Kits ELISA).
a potential link between the upregulation of Syk and VEGF-C (Montrer VEGFC Kits ELISA) expression and lung adenocarcinoma.
The lack of Syk mRNA expression in lung cancer play an important role in angiogenesis.
Overall novel mutations in SYK gene and in silico analysis revealed that these mutations are crucial and might be responsible for altered expression of SYK.
this study shows that SYK increased MUC5AC expression via ERK2 (Montrer MAPK1 Kits ELISA) and p38 MAPK (Montrer MAPK14 Kits ELISA) signaling pathways in airway epithelial cells
Pharmacological Syk inhibition might provide a safe therapeutic strategy to prevent arterial thrombosis and to limit infarct progression in acute stroke.
Studies indicate that SHP1 (Montrer PTPN6 Kits ELISA) and SYK crosstalk as a critical regulator of MyD88 (Montrer MYD88 Kits ELISA) post-translational modifications and IL-1 (Montrer IL1A Kits ELISA)-driven inflammation.
dephosphorylation of Tyr (Montrer TYR Kits ELISA)(P)(346) may be considered an important "checkpoint" in the regulation of Syk activation process. Putative biological functions of TULA-2 (Montrer STS1 Kits ELISA)-mediated dephosphorylation of Tyr (Montrer TYR Kits ELISA)(P)(346) may include deactivation of receptor-activated Syk or suppression of Syk activation by suboptimal stimulation.
These studies define a pathologic role for myeloid Syk signaling in renal ischemia/reperfusion injury
Torreya nucifera butanol fraction exhibits anti-inflammatory activities by direct inhibition of macrophage Src (Montrer SRC Kits ELISA)/Syk/NF-kappaB (Montrer NFKB1 Kits ELISA) and IRAK1 (Montrer IRAK1 Kits ELISA)/AP-1 (Montrer JUN Kits ELISA) signaling.
Dectin-1 (Montrer CLEC7A Kits ELISA) and Dectin-2 (Montrer CLEC6A Kits ELISA) seem not to play a major role in Borrelia recognition or Borrelia-induced inflammation. However, Syk seems to be involved in Borrelia-induced cytokine production
TNF (Montrer TNF Kits ELISA) activates Mule by inducing the dissociation of Mule from its inhibitor ARF. Inhibition of Mule phosphorylation by silencing Syk prevents this, thereby inhibiting Mule E3 ligase activity and TNF (Montrer TNF Kits ELISA)-induced JNK (Montrer MAPK8 Kits ELISA) activation and cell death.
The effects of OXSI-2 identified in this study provide context for the role of Syk in inflammasome signaling and demonstrate its importance in oxidative signaling upstream of inflammasome activation and downstream of ion flux.
Mincle (Montrer CLEC4E Kits ELISA) Activation and the Syk/Card9 (Montrer CARD9 Kits ELISA) Signaling Axis Are Central to the Development of Autoimmune Disease of the Eye
Syk deletion in myeloid cells is protective in mouse nephrotoxic serum nephritis.
These data suggest that Syk mRNA expression dynamics is closely related to bovine leukemia virus-induced disease.
This gene encodes a member of the family of non-receptor type Tyr protein kinases. This protein is widely expressed in hematopoietic cells and is involved in coupling activated immunoreceptors to downstream signaling events that mediate diverse cellular responses, including proliferation, differentiation, and phagocytosis. It is thought to be a modulator of epithelial cell growth and a potential tumour suppressor in human breast carcinomas. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.
Tyrosine-protein kinase SYK
, tyrosine-protein kinase SYK
, protein-tyrosine kinase