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Expression of SYK and its splice variants was significantly lower in tumors with MSI, and in KRAS wild type, BRAF mutant and PTEN mutant tumors
combined use of butyrate and highly specific Syk inhibitor BAY61-3606 does not enhance differentiation and apoptosis of colonocytes. Instead, BAY completely abolishes butyrate-induced differentiation and apoptosis in a Syk- and ERK1/2 (Montrer MAPK1/3 Kits ELISA)-dependent manner.
Study demonstrates that redundant complexes formed by the mutant SYK(Y3F) protein allow it to maintain signaling to receptor-proximal interaction partners, resulting in proper initiation of BCR (Montrer BCR Kits ELISA)-proximal signals.
The study identified the criteria for the design of binders that specifically address either the Syk or the Zap-70 (Montrer ZAP70 Kits ELISA) Tandem Src (Montrer SRC Kits ELISA) Homology 2 Domains, tSH2 (Montrer tshz2 Kits ELISA). While Syk tSH2 (Montrer tshz2 Kits ELISA) has a rather broad substrate scope, ZAP-70 (Montrer ZAP70 Kits ELISA) tSH2 (Montrer tshz2 Kits ELISA) required a proximal arrangement of the phosphotyrosine ligands in defined strand orientation.
SYK mediates the actions of EPO (Montrer EPO Kits ELISA) and GM-CSF (Montrer CSF2 Kits ELISA) and coordinates with TGF-beta (Montrer TGFB1 Kits ELISA) in erythropoiesis.
study demonstrates that high SYK expression is a common feature of CD21 (Montrer CR2 Kits ELISA)(low) B cells independent of the underlying disorder, and that this high expression is sufficient to drive constitutive phosphorylation of SYK and its immediate targets Bruton's tyrosine kinase (Montrer BTK Kits ELISA) and phospholipase Cgamma2
IgG (mAb)-opsonized, inactivated Francisella tularensis LVS enhances macrophage and dendritic cell IL-1beta (Montrer IL1B Kits ELISA) responses in a TLR2 (Montrer TLR2 Kits ELISA)- and FcgammaR-dependent fashion. FcgammaR-mediated Syk activation leads to NLRP3 (Montrer NLRP3 Kits ELISA) inflammasome-dependent IL-1beta (Montrer IL1B Kits ELISA) production in macrophages.
High SYK expression is associated with lymphangioleiomyomatosis.
NKp65 utilizes a hemi-immunoreceptor tyrosine-based activation motif -like motif for cellular activation that requires Syk, although Syk appears not to be recruited to NKp65.
Syk is a key regulator of Hoxa9 (Montrer HOXA9 Kits ELISA)/Meis1 (Montrer MEIS1 Kits ELISA)-driven acute myeloid leukemia (Montrer BCL11A Kits ELISA).
SYK could induce HO-1 (Montrer HMOX1 Kits ELISA) expression by regulating the Akt (Montrer AKT1 Kits ELISA) phosphorylation level in H9c2 with A/H injury, protecting H9c2 from the injury induced by A/H treatment.
identified both Syk and Src (Montrer SRC Kits ELISA) signaling pathways as ones that participate in Borrelia burgdorferi phagocytosis and the resulting cytokine activation.
These results identify Syk as a critical component of skin inflammation in a mouse model of epidermolysis bullosa acquisita
Syk was identified as the target enzyme most strongly inhibited by water extract of Cordyceps bassiana.
The downmodulation of Syk expression and phosphorylation in intestinal DCs could be important mechanisms through which helminths induce regulatory DCs that limit colitis.
ephrin B3 (Montrer EFNB3 Kits ELISA)/EphB2 (Montrer EPHB2 Kits ELISA) are obvious candidates for driving the Syk-dependent repulsive response.
The effect of Smad4 (Montrer SMAD4 Kits ELISA) was at least partially mediated by the downstream effectors Syk and ROCK2 (Montrer ROCK2 Kits ELISA) transcription in megakaryocytes.
Gene expression analysis of lung tissues revealed that HDM (Montrer HDAC3 Kits ELISA)-induced expression of IL-17 (Montrer IL17A Kits ELISA) and CXCL-1 (Montrer CXCL1 Kits ELISA) was significantly attenuated in both Sykdel/del and GSK143-treated mice. CONCLUSION: Syk inhibitors may play a role in the management of neutrophilic asthma
These data suggest that Syk mRNA expression dynamics is closely related to bovine leukemia virus-induced disease.
This gene encodes a member of the family of non-receptor type Tyr protein kinases. This protein is widely expressed in hematopoietic cells and is involved in coupling activated immunoreceptors to downstream signaling events that mediate diverse cellular responses, including proliferation, differentiation, and phagocytosis. It is thought to be a modulator of epithelial cell growth and a potential tumour suppressor in human breast carcinomas. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.
Tyrosine-protein kinase SYK
, tyrosine-protein kinase SYK
, protein-tyrosine kinase