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our data strongly suggest that AQCA-mediated suppression of inflammatory responses could be managed by a direct interference of signaling cascades including IRAK (Montrer IRAK1 Kits ELISA) and Syk, linked to the activation of NF-kappaB (Montrer NFKB1 Kits ELISA) and AP-1 (Montrer FOSB Kits ELISA).
a potential link between the upregulation of Syk and VEGF-C (Montrer VEGFC Kits ELISA) expression and lung adenocarcinoma.
The lack of Syk mRNA expression in lung cancer play an important role in angiogenesis.
Overall novel mutations in SYK gene and in silico analysis revealed that these mutations are crucial and might be responsible for altered expression of SYK.
this study shows that SYK increased MUC5AC expression via ERK2 (Montrer MAPK1 Kits ELISA) and p38 MAPK (Montrer MAPK14 Kits ELISA) signaling pathways in airway epithelial cells
SYK, LYN (Montrer LYN Kits ELISA) and PTPN6 (Montrer PTPN6 Kits ELISA) were markedly elevated in atherosclerotic plaques of carotid atherosclerosis patients.
Syk inhibitor suppressed the phosphorylation of band 3 (Montrer SLC4A1 Kits ELISA) also preventing serine phosphorylation changes and hemolysis.
SYK expression was down-regulated in laryngeal squamous cell carcinoma, which was closely correlated with cancer growth and lymph node metastasis. SYK up-regulation was able to inhibit the invasion and metastasis of LSCC.
TNF (Montrer TNF Kits ELISA) activates Mule (Montrer HUWE1 Kits ELISA) by inducing the dissociation of Mule (Montrer HUWE1 Kits ELISA) from its inhibitor ARF. Inhibition of Mule (Montrer HUWE1 Kits ELISA) phosphorylation by silencing Syk prevents this, thereby inhibiting Mule (Montrer HUWE1 Kits ELISA) E3 ligase activity and TNF (Montrer TNF Kits ELISA)-induced JNK (Montrer MAPK8 Kits ELISA) activation and cell death.
Study establishes P-SYK as a critical biomarker in AML (Montrer RUNX1 Kits ELISA) that identifies tumors sensitive to SYK inhibition, identifies an at-risk patient population, and allows for the monitoring of target inhibition during treatment.
Torreya nucifera butanol fraction exhibits anti-inflammatory activities by direct inhibition of macrophage Src (Montrer SRC Kits ELISA)/Syk/NF-kappaB (Montrer NFKB1 Kits ELISA) and IRAK1 (Montrer IRAK1 Kits ELISA)/AP-1 (Montrer JUN Kits ELISA) signaling.
Dectin-1 (Montrer CLEC7A Kits ELISA) and Dectin-2 (Montrer CLEC6A Kits ELISA) seem not to play a major role in Borrelia recognition or Borrelia-induced inflammation. However, Syk seems to be involved in Borrelia-induced cytokine production
TNF (Montrer TNF Kits ELISA) activates Mule by inducing the dissociation of Mule from its inhibitor ARF. Inhibition of Mule phosphorylation by silencing Syk prevents this, thereby inhibiting Mule E3 ligase activity and TNF (Montrer TNF Kits ELISA)-induced JNK (Montrer MAPK8 Kits ELISA) activation and cell death.
The effects of OXSI-2 identified in this study provide context for the role of Syk in inflammasome signaling and demonstrate its importance in oxidative signaling upstream of inflammasome activation and downstream of ion flux.
Mincle (Montrer CLEC4E Kits ELISA) Activation and the Syk/Card9 (Montrer CARD9 Kits ELISA) Signaling Axis Are Central to the Development of Autoimmune Disease of the Eye
Syk deletion in myeloid cells is protective in mouse nephrotoxic serum nephritis.
Src (Montrer SRC Kits ELISA)/Syk-dependent signalling stabilises platelet adhesion to podoplanin (Montrer PDPN Kits ELISA)
These results provide new insights into the mechanisms by which SYK regulates MHC-II expression via autophagy in macrophages.
Syk mediates airway contractility in the normal and allergic airways, independent of its role and function in leukocytes, and supports a paracrine role for airway epithelial Syk in modulating airway smooth muscle activity.
Syk expression by DCs is necessary for IL-23p19 (Montrer IL23A Kits ELISA) production in response to C. albicans
These data suggest that Syk mRNA expression dynamics is closely related to bovine leukemia virus-induced disease.
This gene encodes a member of the family of non-receptor type Tyr protein kinases. This protein is widely expressed in hematopoietic cells and is involved in coupling activated immunoreceptors to downstream signaling events that mediate diverse cellular responses, including proliferation, differentiation, and phagocytosis. It is thought to be a modulator of epithelial cell growth and a potential tumour suppressor in human breast carcinomas. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.
Tyrosine-protein kinase SYK
, tyrosine-protein kinase SYK
, protein-tyrosine kinase