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anti-Rat (Rattus) MAP3K1 Anticorps:
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Human Polyclonal MAP3K1 Primary Antibody pour DB - ABIN389719
Mokhtari, Myers, Welsh: MAPK kinase kinase-1 is essential for cytokine-induced c-Jun NH2-terminal kinase and nuclear factor-kappaB activation in human pancreatic islet cells. dans Diabetes 2008
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let-7g induces porcine granulosa cells apoptosis by inhibiting the MAP3K1 gene, which promotes FoxO1 (Montrer FOXO1 Anticorps) expression and dephosphorylation with nuclear accumulation.
These results reveal the importance of the MEKK1 (Montrer MAP2K1 Anticorps)-calponin-3 (Montrer CNN3 Anticorps) signaling pathway to cell contractility.
Map3k1 regulates iNKT cell proliferative expansion in response to glycolipid antigen
goya and kinase-deficient Map3k1 homozygotes initially develop supernumerary cochlear outer hair cells (OHCs) that subsequently degenerate.
These data highlight the crucial role of MAP3K1 in the development and function of the mouse inner ear and hearing.
Dioxin exposure markedly inhibited c-Jun (Montrer JUN Anticorps) phosphorylation in Map3k1-deficient embryonic eyelid epithelium, suggesting that dioxin-induced AHR (Montrer AHR Anticorps) pathways can synergize with gene mutations to inhibit MAP3K1 signaling.
Both the MEKK1 (Montrer MAP2K1 Anticorps) PHD (Montrer PDC Anticorps) and TAB1 (Montrer TAB1 Anticorps) are critical for ES-cell differentiation
Results suggest that proto-oncogene (Montrer RAB1A Anticorps) protiins c-Jun (Montrer JUN Anticorps) and mitogen-activated protein 3 (Montrer HSPB3 Anticorps) kinase 1 (MAP3K1) represent parallel pathways in the control of eyelid closure.
Aberrant expression of Map3k1 enabled growth factor-autonomous proliferation and drove BRAF (Montrer BRAF Anticorps)-independent ERK (Montrer EPHB2 Anticorps) signaling, thus shedding light on alternative means of activating this prominent signaling pathway in melanoma.
analysis of the gene expression program of MAP3K1 in mouse eyelid morphogenesis
Proximal to the RING domain is a SWIM (SWI2/SNF2 (Montrer SMARCA4 Anticorps) and MuDR) domain. The MEKK1 (Montrer MAP2K1 Anticorps) SWIM domain, but not the RING domain, directly associates with the c-Jun (Montrer JUN Anticorps) DNA-binding domain, and the SWIM domain is required for MEKK1 (Montrer MAP2K1 Anticorps)-dependent c-Jun (Montrer JUN Anticorps) ubiquitylation.
double mekk1/camta3 mutant positioned CAMTA3 downstream of MEKK1 and verified their distinct roles in GSR (Montrer GSR Anticorps) regulation. mekk1-5 displays programmed cell death and overaccumulates reactive oxygen species and salicylic acid
Treatment of Arabidopsis with a membrane rigidifier, DMSO, causes MPK4 (Montrer MAPK4 Anticorps) activation concomitantly with MEKK1 and MKK2 (Montrer MAP2K2 Anticorps) phosphorylation.
Ca(2 (Montrer CA2 Anticorps)+) signaling occurred upstream of the MEKK1-MKK2 (Montrer MAP2K2 Anticorps) pathway. MEKK1 was phosphorylated by calcium/calmodulin (Montrer CALM Anticorps)-regulated receptor-like kinase (CRLK1), which suggested that CRLK1 is one of candidates located upstream of MEKK1.
MEKK1 plays a key role in transducing the l-Glu (Montrer DCTN1 Anticorps) signal that elicits large-scale changes in root architecture, and provide genetic evidence for the existence in plants of an external glutamate (Montrer GRIN2A Anticorps) (l-Glu (Montrer DCTN1 Anticorps)) signalling pathway analogous to that found in animals.
Data indicate that MEKK2 (Montrer MAP3K2 Anticorps) is required for the mekk1, mkk1 (Montrer MAP2K1 Anticorps) mkk2 (Montrer MAP2K2 Anticorps), and mpk4 (Montrer MAPK4 Anticorps) autoimmune phenotypes.
Data suggest that the MEKK1-MKK1 (Montrer MAP2K1 Anticorps)/MKK2 (Montrer MAP2K2 Anticorps)-MPK4 (Montrer MAPK4 Anticorps) kinase cascade negatively regulates MEKK2 (Montrer MAP3K2 Anticorps) and activation of MEKK2 (Montrer MAP3K2 Anticorps) triggers SUMM2-mediated immune responses.
CRLK1 interacts with MEKK1 in vitro and in planta during cold treatment.
An analysis of the interation of MEKK1 and MEK1 (Montrer MAP2K1 Anticorps) in response to wounding stress in A. thaliana seedlings is presented.
MEKK1 is essential for activation of MPK4 and negatively regulates temperature-sensitive and tissue-specific cell death and H(2)O(2) accumulation that are dependent on both RAR1 (resistance protein function) and SID2 (isochorismate synthase)
This study demonstrated that analysis of plants carrying T-DNA knockout alleles indicated that MEKK1 is required for flg22-induced activation of MPK4 (Montrer MAPK4 Anticorps).
Polymorphism of MAP3K1 is associated with breast cancer.
SNP variants at the MAP3K1/SETD9 gene boundary associate with somatic PIK3CA (Montrer PIK3CA Anticorps) variants in breast cancers.
CSN6 (Montrer COPS6 Anticorps) positively regulates c-Jun (Montrer JUN Anticorps) in a MEKK1-dependent manner
Mekk1 mediates p53 protein stability in the presence of Mdm2 and reduces p53 ubiquitination, suggesting an interference with Mdm2-mediated degradation of p53 by the ubiquitin-proteasome pathway.
BAALC (Montrer BAALC Anticorps) conferred chemoresistance in acute myeloid leukemia (Montrer BCL11A Anticorps) cells by upregulating ATP-binding cassette proteins in an ERK (Montrer EPHB2 Anticorps)-dependent manner, which can be therapeutically targeted by MEK (Montrer MAP2K1 Anticorps) inhibitor
MiR (Montrer MLXIP Anticorps)-451 inhibited the proliferation of esophageal squamous cell carcinoma cells by targeting CDKN2D (Montrer CDKN2D Anticorps) and MAP3K1 expression.
There were 3 specimens with mutations in MAP3K1 (MEKK1), including two truncation mutants, T779fs and T1481fs; T1481fs encoded an unstable and nonfunctional protein when expressed in vitro.
Single nucleotide polymorphisms in ALDOB (Montrer ALDOB Anticorps), MAP3K1, and MEF2C (Montrer MEF2C Anticorps) are associated with cataract.
Results demonstrate that MAP3K1 rs889312 is closely correlated with outcome among diffuse-type gastric cancer in a Chinese population.
We propose that the cancer risk alleles act to increase MAP3K1 expression in vivo and might promote breast cancer cell survival.
The protein encoded by this gene is a serine/threonine kinase and is part of some signal transduction cascades, including the ERK and JNK kinase pathways as well as the NF-kappa-B pathway. The encoded protein is activated by autophosphorylation and requires magnesium as a cofactor in phosphorylating other proteins. This protein has E3 ligase activity conferred by a plant homeodomain (PHD) in its N-terminus and phospho-kinase activity conferred by a kinase domain in its C-terminus.
mitogen-activated protein kinase kinase kinase 1
, MAPK/ERK kinase kinase 1
, MEK kinase 1
, MEKK 1
, mitogen activated protein kinase kinase kinase 1
, MAP/ERK kinase kinase 1