Aperçu des produits pour anti-MAP3K8 (MAP3K8) Anticorps

Full name:
anti-Mitogen-Activated Protein Kinase Kinase Kinase 8 Anticorps (MAP3K8)
Chez www.anticorps-enligne.fr sont 101 Mitogen-Activated Protein Kinase Kinase Kinase 8 (MAP3K8) Anticorps de 16 de différents fournisseurs disponibles. De plus, nous expédions MAP3K8 Protéines (9) et MAP3K8 Kits (5) et beaucoup plus de produits pour cette protéine. Un total de 128 MAP3K8 produits sont actuellement listés.
Synonymes:
c-COT, Cot, Cot/Tpl2, D17TPL2, Est, Estf, MAP3K8, MEKK8, Tpl-2, Tpl2

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anti-Human MAP3K8 Anticorps:

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anti-MAP3K8 Anticorps mieux référencés

  1. Human Polyclonal MAP3K8 Primary Antibody pour EIA, IHC (p) - ABIN360360 : Shlomchik, Zharhary, Saunders, Camper, Weigert: A rheumatoid factor transgenic mouse model of autoantibody regulation. dans International immunology 1994 (PubMed)
    Show all 5 references for 360360

  2. Human Polyclonal MAP3K8 Primary Antibody pour EIA - ABIN358351 : Sánchez-Góngora, Lisbona, de Gregorio, Ballester, Calvo, Pérez-Jurado, Alemany: COT kinase proto-oncogene expression in T cells: implication of the JNK/SAPK signal transduction pathway in COT promoter activation. dans The Journal of biological chemistry 2000 (PubMed)
    Show all 5 references for 358351

  3. Human Polyclonal MAP3K8 Primary Antibody pour IHC, ELISA - ABIN1532057 : Chan, Chedid, McGovern, Popescu, Miki, Aaronson: Expression cDNA cloning of a serine kinase transforming gene. dans Oncogene 1993 (PubMed)

  4. Cow (Bovine) Polyclonal MAP3K8 Primary Antibody pour WB - ABIN2779366 : Wittwer, Schmitz: NIK and Cot cooperate to trigger NF-kappaB p65 phosphorylation. dans Biochemical and biophysical research communications 2008 (PubMed)

  5. Cow (Bovine) Polyclonal MAP3K8 Primary Antibody pour WB - ABIN2779365 : Jia, Quinn, Bump, Clark, Clabbers, Hardman, Gagnon, Kamens, Tomlinson, Wishart, Allen: Purification and kinetic characterization of recombinant human mitogen-activated protein kinase kinase kinase COT and the complexes with its cellular partner NF-kappa B1 p105. dans Archives of biochemistry and biophysics 2005 (PubMed)

Plus d’anticorps contre MAP3K8 partenaires d’interaction

Human Mitogen-Activated Protein Kinase Kinase Kinase 8 (MAP3K8) interaction partners

  1. rs1042058 GG Crohn's disease -risk polymorphism in TPL2 results in a gain-of-function by increasing TPL2 expression and signalling, thereby amplifying Pattern recognition receptor -initiated outcomes.

  2. MAP3K8 is a direct target of miR (Montrer MLXIP Anticorps)-144-3p, and miR (Montrer MLXIP Anticorps)-144-3p downregulation is a factor in renal cell carcinoma (Montrer MOK Anticorps) progression through potentiation of MAP3K8 expression.

  3. Taken together, these results suggest that Cot kinase might play a critical role in Helicobacter pylori type IV secretion apparatus-dependent early IL-8 (Montrer IL8 Anticorps) secretion and CagA (Montrer S100A8 Anticorps)-dependent late IL-8 (Montrer IL8 Anticorps) secretion as an alternative signaling molecule in the Erk (Montrer EPHB2 Anticorps) pathway.

  4. Studies indicate that Tpl2, a MAP3K, participates in a broad range of cancer-related signaling pathways and induces tumorigenesis and progression of many cancers.

  5. the results of the present study demonstrated that the miR (Montrer MLXIP Anticorps)-509-3p RCC (Montrer XRCC1 Anticorps) suppressor was a significant regulator of the MAP3K8 oncogene (Montrer RAB1A Anticorps), suggesting that it may have a potential therapeutic role in the treatment of renal cell carcinoma (Montrer MOK Anticorps)

  6. findings provide a novel perspective on the role of the IL-33 (Montrer IL33 Anticorps)/ST2 (Montrer SULT2A1 Anticorps)/COT signaling pathway in supporting cancer-associated inflammation in the tumor microenvironment

  7. structurally versatile active site significantly impacts the design of potent, low molecular weight COT kinase inhibitors

  8. TPL2 mediates the phosphorylation of a fraction of nucleophosmin (Montrer NPM1 Anticorps) at threonine 199, an event required for its proteasomal degradation and maintenance of steady-state nucleophosmin (Montrer NPM1 Anticorps) levels.

  9. MAP3K8 and miR-17-5p expression were inversely correlated with treatment response

  10. COT interacts with and phosphorylates Pin1 (Montrer PIN1 Anticorps) on Ser16. Consequently, Pin1 (Montrer PIN1 Anticorps) Ser16 phosphorylation by COT increases cyclin D1 (Montrer CCND1 Anticorps) abundance and enhances tumorigenecity of MCF7 cells.

Mouse (Murine) Mitogen-Activated Protein Kinase Kinase Kinase 8 (MAP3K8) interaction partners

  1. this study shows that TPL-2 deficiency leads to severe house duct mite-induced airway allergy, when compared with wild-type mice

  2. The kinase TPL2 activates ERK (Montrer EPHB2 Anticorps) and p38 (Montrer CRK Anticorps) signaling to promote neutrophilic inflammation

  3. TPL2 kinase is a crucial signaling factor in iNKT cells and major mediator of hepatic inflammation.

  4. Taken together this study identified that TPL-2 regulated TH2-mediated inflammation by supporting lipolysis and M2 macrophage activation, preventing TH2 cell expansion and downstream immunopathology and fibrosis.

  5. Map3k8 decreases apoptosis of monocytes and enhances CCR2 (Montrer CCR2 Anticorps) expression on Ly6C(high)CD11c (Montrer ITGAX Anticorps)(low) monocytes of atherosclerotic ApoE (Montrer APOE Anticorps)(-/-) mice fed an high fat diet.

  6. results demonstrate that Tpl2 promotes inflammation in part by constraining FoxP3 (Montrer FOXP3 Anticorps) expression and Treg immunosuppressive functions.

  7. Tpl2 plays a significant role in promoting HCC (Montrer FAM126A Anticorps) development by its pro-inflammatory effect, which suggested that Tpl2 could be a molecular target for HCC (Montrer FAM126A Anticorps) prevention.

  8. Tpl2 null mice displayed low COX-2 (Montrer COX2 Anticorps) mRNA induction in adipose tissue.

  9. The stimulating effect of estradiol on progesterone synthesis relies on the estrogen no-classical protein-coupled receptor 30, and MAP3K8.

  10. these findings establish an essential role for Tpl2 in antiviral host defense mechanisms.

MAP3K8 profil antigène

Antigen Summary

This gene is an oncogene that encodes a member of the serine/threonine protein kinase family. The encoded protein localizes to the cytoplasm and can activate both the MAP kinase and JNK kinase pathways. This protein was shown to activate IkappaB kinases, and thus induce the nuclear production of NF-kappaB. This protein was also found to promote the production of TNF-alpha and IL-2 during T lymphocyte activation. This gene may also utilize a downstream in-frame translation start codon, and thus produce an isoform containing a shorter N-terminus. The shorter isoform has been shown to display weaker transforming activity. Alternate splicing results in multiple transcript variants that encode the same protein.

Alternative names and synonyms associated with MAP3K8

  • mitogen-activated protein kinase kinase kinase 8 (MAP3K8) anticorps
  • mitogen-activated protein kinase kinase kinase 8 (map3k8) anticorps
  • mitogen-activated protein kinase kinase kinase 8 (Map3k8) anticorps
  • c-COT anticorps
  • Cot anticorps
  • Cot/Tpl2 anticorps
  • D17TPL2 anticorps
  • Est anticorps
  • Estf anticorps
  • MAP3K8 anticorps
  • MEKK8 anticorps
  • Tpl-2 anticorps
  • Tpl2 anticorps

Protein level used designations for MAP3K8

mitogen-activated protein kinase kinase kinase 8 , Ewing sarcoma transformant , cot (cancer Osaka thyroid) oncogene , proto-oncogene c-Cot , proto-oncogene serine/threoine protein kinase , tumor progression locus 2 , COT proto-oncogene serine/threonine-protein kinase , cancer Osaka thyroid oncogene , cancer Osaka thyroid, oncogene , mitogen activated protein kinase kinase kinase 8 , serine/threonine-protein kinase cot , serine/threonine kinase (Tpl-2)

GENE ID SPECIES
450384 Pan troglodytes
100018684 Monodelphis domestica
100063602 Equus caballus
100355566 Oryctolagus cuniculus
100385107 Callithrix jacchus
100480593 Ailuropoda melanoleuca
100541097 Meleagris gallopavo
100562883 Anolis carolinensis
100579516 Nomascus leucogenys
420479 Gallus gallus
1326 Homo sapiens
487085 Canis lupus familiaris
535622 Bos taurus
26410 Mus musculus
116596 Rattus norvegicus
449002 Sus scrofa
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