MAP3K8 anticorps (pSer400)

N° du produit ABIN7138601

Détail du produit anti-MAP3K8 anticorps

Antigène: MAP3K8 (Mitogen-Activated Protein Kinase Kinase Kinase 8 (MAP3K8))

Épitope: pSer400

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp MAP3K8 est non-conjugé

Application: ELISA, Immunohistochemistry (IHC)

Réactivité croisée: Humain, Souris, Rat

Purification: Antibodies were produced by immunizing rabbits with synthetic phosphopeptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific phosphopeptide. Non-phospho specific antibodies were removed by chromatogramphy usi

Immunogène: Peptide sequence around phosphorylation site of Serine 400(C-Q-S(p)-L-D) derived from HumanMAP3K8.

Isotype: IgG

Information d'application

Indications d'application: IHC:1:50-1:100,

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C,-80 °C

Stockage commentaire: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Détails sur MAP3K8

Antigène: MAP3K8 (Mitogen-Activated Protein Kinase Kinase Kinase 8 (MAP3K8))

Autre désignation: MAP3K8 (MAP3K8 Produits)

Synonymes: anticorps MAP3K8, anticorps COT, anticorps EST, anticorps ESTF, anticorps MEKK8, anticorps TPL2, anticorps Tpl-2, anticorps c-COT, anticorps Cot, anticorps Cot/Tpl2, anticorps Est, anticorps Estf, anticorps Tpl2, anticorps D17TPL2, anticorps mitogen-activated protein kinase kinase kinase 8, anticorps MAP3K8, anticorps map3k8, anticorps Map3k8

Sujet:

Background:

This gene was identified by its oncogenic transforming activity in cells. The encoded protein is a member of the serine/threonine protein kinase family. This kinase can activate both the MAP kinase and JNK kinase pathways. This kinase was shown to activate IkappaB kinases, and thus induce the nuclear production of NF-kappaB. This kinase was also found to promote the production of TNF-alpha and IL-2 during T lymphocyte activation. Studies of a similar gene in rat suggested the direct involvement of this kinase in the proteolysis of NF-kappaB1,p105 (NFKB1).

Miyoshi J., Mol. Cell. Biol. 11:4088-4096(1991).
Aoki M., J. Biol. Chem. 268:22723-22732(1993).
Chan A.M.,Oncogene 8:1329-1333(1993).

Aliases: AURA2 antibody, c COT antibody, Cancer Osaka thyroid oncogene antibody, CCOT antibody, COT antibody, COT proto oncogene serine/threonine protein kinase antibody, EST antibody, ESTF antibody, Ewing sarcoma transformant antibody, FLJ10486 antibody, M3K8_HUMAN antibody, MAP3K 8 antibody, MAP3K8 antibody, MEKK8 antibody, Mitogen activated protein kinase kinase kinase 8 antibody, Mitogen-activated protein kinase kinase kinase 8 antibody, Proto oncogene cCot antibody, Proto-oncogene c-Cot antibody, Serine/threonine protein kinase cot antibody, Serine/threonine-protein kinase cot antibody, TPL 2 antibody, TPL-2 antibody, TPL2 antibody, Tumor progression locus 2 antibody

UniProt: P41279

Pathways: Signalisation PI3K-Akt, TCR Signaling