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Inhibition of Snapin enhanced localization of HIV-1 with TLR8 (Montrer TLR8 Kits ELISA)(+) early endosomes, triggered a pro-inflammatory response, and inhibited trans-infection of CD4 (Montrer CD4 Kits ELISA)(+) T cells.
Taken together, these results suggest that Snapin, the pUL130 interacting protein, has a role in modulating HCMV DNA synthesis.
Disruption of Snapin-PKR2 (Montrer PROKR2 Kits ELISA) interaction did not affect PKR2 (Montrer PROKR2 Kits ELISA) signaling, but increased the ligand-induced degradation, implying a role of Snapin in the trafficking of PKR2 (Montrer PROKR2 Kits ELISA).
Authors propose that Snapin connects chlamydial inclusions with the microtubule network by interacting with both Chlamydia psittaci IncB and dynein.
Snapin, a SNAP (Montrer NAPA Kits ELISA)-25 (synaptosomal-associated protein-25 (Montrer SNAP25 Kits ELISA)) interacting protein, interacts with LRRK2 (Montrer LRRK2 Kits ELISA).
Our findings reveal that Atg14L, previously considered to be solely a Beclin 1 (Montrer BECN1 Kits ELISA)-binding autophagy protein, plays a novel role in the late stage of endocytic trafficking in conjunction with Snapin
These observations identify Snapin as a novel endogenous TLR2 (Montrer TLR2 Kits ELISA) ligand in rheumatoid arthritis, and thus support a role for persistent TLR2 (Montrer TLR2 Kits ELISA) signalling in pathogenesis.
These results suggest that Snapin may play a key role in regulating the cellular localization of human cytomegalovirus UL70, leading to modulation of viral DNA synthesis and progeny production.
PKA-dependent phosphorylation of snapin increases interaction among insulin (Montrer INS Kits ELISA) secretory vesicle-associated proteins, thereby potentiating glucose-stimulated insulin (Montrer INS Kits ELISA) secretion.
results suggest that RGS7 (Montrer RGS7 Kits ELISA) could play a role in synaptic vesicle exocytosis through its interaction with snapin
Snapin-dysbindin interaction regulates synaptic vesicle positional priming through BLOC-1/AP-3-dependent sorting.
Snapin reduces APP (Montrer APP Kits ELISA) processing by enhancing BACE1 (Montrer BACE Kits ELISA) lysosomal degradation.
Transmembrane prostatic acid phosphatase (Montrer ACPP Kits ELISA) (TMPAP) interacts with snapin and deficient mice develop prostate adenocarcinoma.
Snapin accelerates exocytosis at low intracellular calcium concentration in mouse chromaffin cells.
Snapin-dynein coupling is one of the primary mechanisms driving BDNF (Montrer BDNF Kits ELISA)-TrkB (Montrer NTRK2 Kits ELISA) retrograde transport, thus providing mechanistic insights into the regulation of neuronal growth and survival.
AC6 (Montrer ADCY6 Kits ELISA)-mediated inhibition of neurite outgrowth was reversed by the overexpression of Snap25 (Montrer SNAP25 Kits ELISA) or a Snapin mutant that could not be phosphorylated.
Snapin has a role in regulating autophagy-lysosomal function
Snapin deficiency leads to reduced cell density in cortical plates, apoptotic death in the cortex & third ventricle, enhanced membrane-bound LC3 (Montrer MAP1LC3A Kits ELISA)-II staining, and accumulation of polyubiquitinated proteins in the cortex and hippocampus in knockout mice
highlights new mechanistic insights into how Snapin-intermediate chain coordinates retrograde transport and late endosomal-lysosomal trafficking critical for autophagy-lysosomal function, and thus neuronal homeostasis.
The protein encoded by this gene is a coiled-coil-forming protein that associates with the SNARE (soluble N-ethylmaleimide-sensitive fusion protein attachment protein receptor) complex of proteins and the BLOC-1 (biogenesis of lysosome-related organelles) complex. Biochemical studies have identified additional binding partners. As part of the SNARE complex, it is required for vesicle docking and fusion and regulates neurotransmitter release. The BLOC-1 complex is required for the biogenesis of specialized organelles such as melanosomes and platelet dense granules. Mutations in gene products that form the BLOC-1 complex have been identified in mouse strains that are models of Hermansky-Pudlak syndrome. Alternative splicing results in multiple transcript variants.
, SNARE-associated protein Snapin
, BLOC-1 subunit 7
, SNAP-25-binding protein
, SNARE associated protein snapin
, biogenesis of lysosomal organelles complex-1, subunit 7
, biogenesis of lysosome-related organelles complex 1 subunit 7
, synaptosomal-associated protein 25-binding protein
, synaptosomal-associated protein 25 binding protein
, synaptosomal-associated protein, 25 kDa, binding protein