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ADAMTS13 encodes a member of the ADAMTS (a disintegrin and metalloproteinase with thrombospondin motif) protein family. De plus, nous expédions ADAMTS13 Kits (38) et ADAMTS13 Protéines (6) et beaucoup plus de produits pour cette protéine.
Showing 10 out of 101 products:
Human Polyclonal ADAMTS13 Primary Antibody pour WB - ABIN152016
Tao, Wang, Choi, Bernardo, Nishio, Sadler, López, Dong: Cleavage of ultralarge multimers of von Willebrand factor by C-terminal-truncated mutants of ADAMTS-13 under flow. dans Blood 2005
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Human Polyclonal ADAMTS13 Primary Antibody pour ELISA, IHC - ABIN4278265
Ganburged, Suda, Saito, Yamazaki, Isokawa, Moriyama: Dilated capillaries, disorganized collagen fibers and differential gene expression in periodontal ligaments of hypomorphic fibrillin-1 mice. dans Cell and tissue research 2010
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Human Polyclonal ADAMTS13 Primary Antibody pour IP, WB - ABIN251718
Feng, Eyler, Zhang, Maga, Nester, Kroll, Smith, Afshar-Kharghan: Partial ADAMTS13 deficiency in atypical hemolytic uremic syndrome. dans Blood 2013
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Human Polyclonal ADAMTS13 Primary Antibody pour WB - ABIN251717
Turner, Nolasco, Ruggeri, Moake: Endothelial cell ADAMTS-13 and VWF: production, release, and VWF string cleavage. dans Blood 2009
ADAMTS13 haplotype had an independent protective effect on CAD (Montrer CAD Anticorps) and genetic variation of vWF (Montrer VWF Anticorps) V1565L polymorphism modulates ADAMTS13 activity.
The relative deficiency of plasma ADAMTS13 activity in subarachnoid haemorrhage patients may associate with worse outcome.
Low ADAMTS13 was associated with increased mortality in patients with severe sepsis and septic shock and was comparable to APACHE II scores for predicting mortality.
These observations support the hypothesis that a significantly reduced ADAMTS13/VWF (Montrer VWF Anticorps) ratio in the coronary artery flow plays a pathogenic role in acute coronary syndromes (ACS (Montrer PLA2G15 Anticorps)) and suggest that transition from laminar to turbulent flow at sites of coronary stenosis further enhances VWF (Montrer VWF Anticorps) activation and deposition.
Low ADAMTS-13 activity is associated with an increased risk of coronary heart disease in the elderly, independently of VWF (Montrer VWF Anticorps) and established cardiovascular risk factors
As folding stability was progressively disrupted, proteolysis by ADAMTS13 increased. Due to the range of folding stabilities and wide distribution of VWF (Montrer VWF Anticorps) A2 domain mutations studied, we conclude that these mutations disrupt regulated folding of the VWF (Montrer VWF Anticorps) A2 domain
The 'closed' conformation of ADAMTS-13 restricts its specificity and protects against fibrinogenolysis
Our results indicate that the secondary TMA syndrome and its poor outcome is characterized by relative ADAMTS13 deficiency, inflammation, and complement activation with consumption via the classical and alternative pathways.
Diagnosis of thrombotic thrombocytopenic purpura among patients with ADAMTS13 Activity 10%-20.
Rare genetic variants in the ADAMTS13 on Willebrand factor-binding domain contribute to pediatric stroke.
Adamts13 deficiency in obese mice promotes hepatic microthrombosis.
results suggest that ADAMTS13 controls key steps of ischemic vascular remodeling and that recombinant ADAMTS13 is a putative therapeutic avenue for promoting stroke recovery.
ADAMTS13 retards progression of diabetic nephropathy, most likely by inhibiting VWF (Montrer VWF Anticorps)-dependent intrarenal thrombosis.
administration of ADAMTS13 5 minutes after occlusion dose-dependently dissolved these t-PA (Montrer PLAT Anticorps)-resistant thrombi resulting in fast restoration of MCA (Montrer RSPH1 Anticorps) patency and consequently reduced cerebral infarct sizes
Sleeping beauty transposon-mediated gene therapy achieved sustained expression of transgene ADAMTS13 and long-term prophylaxis against congenital thrombotic thrombocytopenic purpura in Adamts13(-/-) mice.
Results also suggest that Toxoplasma gondii-mediated apoptosis might play a pivotal role and a different type of role in the mechanism of neurodegeneration and neuropathology in the process of toxoplasma encephalitis. Furthermore, expression of ADAMTS-13 might give an idea of the progress and is critical for diagnosis of this disease.
Letter: deficiency of ADAMTS13 results in increased formation of venous thrombosis in mice.
ADAMTS13 substrate specificity
Data indicate that the p.D187H mutation impairs ADAMTS13 activity and secretion and may contribute to thrombotic thrombocytopenic purpura.
Data show that metalloendopeptidase (Montrer THOP1 Anticorps) ADAMTS13 does not directly promote development of adipose tissue.
This gene encodes a member of the ADAMTS (a disintegrin and metalloproteinase with thrombospondin motif) protein family. Members of the family share several distinct protein modules, including a propeptide region, a metalloproteinase domain, a disintegrin-like domain, and a thrombospondin type 1 (TS) motif. Individual members of this family differ in the number of C-terminal TS motifs, and some have unique C-terminal domains. The enzyme encoded by this gene is the von Willebrand Factor (vWF)-cleaving protease, which is responsible for cleaving at the site of Tyr842-Met843 of the vWF molecule. A deficiency of this enzyme is associated with thrombotic thrombocytopenic purpura. Alternative splicing of this gene generates multiple transcript variants encoding different isoforms.
ADAM metallopeptidase with thrombospondin type 1 motif, 13
, A disintegrin and metalloproteinase with thrombospondin motifs 13
, a disintegrin-like and metalloprotease (reprolysin type) with thrombospondin type 1 motif, 13
, vWF-cleaving protease
, von Willebrand factor-cleaving protease
, ADAM-TS 13
, ADAMTS13 isoform IAP-b
, vWF-CP mRNA for von Willebrand factor-cleaving
, ADAM metallopeptidase with thrombospondin type 1 motif, 13 isoform 1 preproprotein-like
, ADAM metallopeptidase with thrombospondin type 1 motif, 12
, A disintegrin and metalloproteinase with thrombospondin motifs 12
, A disintegrin and metalloproteinase with thrombospondin motifs 13-like
, a disintegrin-like and metallopeptidase (reprolysin type) with thrombospondin type 1 motif, 13