anti-ADAM Metallopeptidase with Thrombospondin Type 1 Motif, 13 (ADAMTS13) Anticorps

ADAMTS13 encodes a member of the ADAMTS (a disintegrin and metalloproteinase with thrombospondin motif) protein family. De plus, nous expédions ADAMTS13 Kits (42) et ADAMTS13 Protéines (8) et beaucoup plus de produits pour cette protéine.

afficher tous les anticorps Gène GeneID UniProt
ADAMTS13 11093 Q76LX8
ADAMTS13 279028 Q769J6
ADAMTS13 102554393  
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Top anti-ADAMTS13 Anticorps sur anticorps-enligne.fr

Showing 10 out of 91 products:

Catalogue No. Reactivité Hôte Conjugué Application Images Quantité Fournisseur Livraison Prix Détails
Humain Lapin Inconjugué EIA, IHC (p), WB Immunohistochemistry: ADAMTS13 antibody staining of Formalin-Fixed Paraffin-Embedded Human hepatocarcinoma followed by peroxidase-conjugation to the secondary antibody and DAB staining. Western blot analysis: ADAMTS13 antibody staining of CEM cell line lysates (35 µg/lane). ADAMTS13 (arrow) was detected using the purified Pab. 0.4 mL Connectez-vous pour afficher 6 to 8 Days
$390.50
Détails
Humain Lapin Inconjugué WB Detection of Recombinant Human Adam-TS13 by Western Blot. Samples: Purified recombinant Adam-TS13. Antibody: ABIN152016 used at the indicated concentrations. Detection: Chemiluminescence with an exposure time of approximately 30 seconds. Western Blot: ADAMTS13 Antibody  - Purified recombinant Adam-TS13. Antibody used at the indicated concentrations. 100 μL Connectez-vous pour afficher 7 to 9 Days
$559.35
Détails
Humain Lapin Inconjugué ELISA, WB Western blot analysis of ADAMTS13 expression in rat brain extract ( Lane 1), mouse liver extract ( Lane 2) and HEPG2 whole cell lysates ( Lane 3). ADAMTS13 at 154KD was detected using rabbit anti- ADAMTS13 Antigen Affinity purified polyclonal antibody (Catalog # ) at 0.5 ??g/mL. The blot was developed using chemiluminescence (ECL) method (Catalog # EK1002). 100 μg Connectez-vous pour afficher 4 to 6 Days
$240.00
Détails
Humain Lapin Inconjugué IHC (p), WB Western blot analysis of anti-ADAMTS13 Antibody (Center)(ABIN391641) in CEM cell line lysates (35 µg/lane). ADAMTS13 (arrow) was detected using the purified polyclonal antibody. Formalin-fixed and paraffin-embedded human hepatocarcinoma with ADAMTS13 Antibody (Center), which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. 400 μL Connectez-vous pour afficher 10 to 11 Days
$385.00
Détails
Humain Chèvre Inconjugué IP, WB 100 μL Connectez-vous pour afficher 7 to 9 Days
$559.35
Détails
Humain Chèvre Inconjugué WB 100 μL Connectez-vous pour afficher 7 to 9 Days
$559.35
Détails
Humain Lapin Inconjugué ELISA, IHC, WB Western blot analysis of ADAMTS13 using HeLa whole cell lysates ABIN6279085 at 1/100 staining Human melanoma tissue by IHC-P. The sample was formaldehyde fixed and a heat mediated antigen retrieval step in citrate buffer was performed. The sample was then blocked and incubated with the antibody for 1.5 hours at 22¡ãC. An HRP conjugated goat anti-rabbit antibody was used as the secondary 100 μL Connectez-vous pour afficher 11 to 12 Days
$390.77
Détails
Humain Souris Inconjugué CyTOF, FACS, IP, WB Detection of ADAMTS13 in HUVEC Human Cells by Flow Cytometry. HUVEC human umbilical vein endothelial cells were stained with Mouse Anti-Human ADAMTS13 Monoclonal Antibody. To facilitate intracellular staining, cells were fixed with paraformaldehyde and permeabilized with saponin. 100 μg Connectez-vous pour afficher 8 to 9 Days
$250.86
Détails
Humain Lapin Inconjugué IHC (p), WB Western blot analysis of anti-ADAMTS13 Antibody in CEM cell line lysates (35ug/lane) Formalin-fixed and paraffin-embedded human hepatocarcinoma with ADAMTS13 Antibody , which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. 400 μL Connectez-vous pour afficher 2 to 3 Days
$515.63
Détails
Humain Chèvre Inconjugué IHC, IHC (p), WB Anti-ADAMTS13 antibody IHC staining of human liver. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml. 50 μL Connectez-vous pour afficher 11 to 14 Days
$639.83
Détails

anti-ADAMTS13 Anticorps mieux référencés

  1. Human Polyclonal ADAMTS13 Primary Antibody pour WB - ABIN152016 : Tao, Wang, Choi, Bernardo, Nishio, Sadler, López, Dong: Cleavage of ultralarge multimers of von Willebrand factor by C-terminal-truncated mutants of ADAMTS-13 under flow. dans Blood 2005 (PubMed)
    Show all 5 Pubmed References

  2. Human Polyclonal ADAMTS13 Primary Antibody pour IP, WB - ABIN251718 : Feng, Eyler, Zhang, Maga, Nester, Kroll, Smith, Afshar-Kharghan: Partial ADAMTS13 deficiency in atypical hemolytic uremic syndrome. dans Blood 2013 (PubMed)
    Show all 2 Pubmed References

  3. Human Polyclonal ADAMTS13 Primary Antibody pour WB - ABIN251717 : Turner, Nolasco, Ruggeri, Moake: Endothelial cell ADAMTS-13 and VWF: production, release, and VWF string cleavage. dans Blood 2009 (PubMed)

Plus d’anticorps contre ADAMTS13 partenaires d’interaction

Human ADAM Metallopeptidase with Thrombospondin Type 1 Motif, 13 (ADAMTS13) interaction partners

  1. acute myeloid leukemia patients with low activity of ADAMTS-13 had worse prognosis after bone morrow transplantation.

  2. The Plasma Levels of ADAMTS-13, von Willebrand Factor, VWFpp, and Fibrin-Related Markers in Patients With Systemic Sclerosis Having Thrombosis

  3. The aim of the study was to investigate the role of von Willebrand factor (vWF), the vWF-cleaving protease, ADAMTS13, the composition of thrombus, and patient outcome following mechanical cerebral artery thrombectomy in patients with acute ischemic stroke.

  4. ADAMTS 1, 4, 12, and 13 levels in the maternal and cord blood were lower in the preeclampsia group than in the control group. ADAMTS 1, 4, and 12 levels in placental tissues were higher in the preeclampsia group.

  5. Decreased ADAMTS-13 activity was found in patients with proliferative lupus nephritis, and plasma ADAMTS-13 activity was closely associated with renal injury indices.

  6. These results suggest that highly elevated plasma VWF might accelerate platelet thrombus formation not only in the circulation but also on the surface of vascular endothelial cells in the setting of ADAMTS13 deficiency in Upshaw-Schulman syndrome.

  7. Prothrombotic state and systemic inflammation status might contribute to explaining the high incidence of concealed chronic renal failure in COPD, and plasma ADAMTS-13 levels may serve as a strong predictor.

  8. VWF, GMP-140, ADAMTS13 and the cerebral vasospasm, delayed cerebral ischemia, tumor diameter and prognosis of aneurysmal subarachnoid hemorrhage patients are closely related

  9. The levels of ADAMTS13 among neonates were higher as compared with healthy adults, despite a significant elevation of VWF antigen (Ag) and Ristocetin cofactor (RiCof) noted in all neonates.

  10. investigated the roles of ADAMTS13 and VWF in thrombotic events of patients with Connective Tissue Diseases

  11. Studied the significance of the von Willebrand factor (VWF)/ ADAMTS-13 ratio in advanced non-small-cell lung cancer (NSCLC). Findings suggest that the imbalance between VWF secretion and ADAMTS-13 may play a role in the hypercoagulability state in advanced NSCLC, and increase of the plasma VWF/ADAMTS-13 ratio may serve as an independent predictive factor for mortality in patients with advanced NSCLC.

  12. vaso-occlusive crisis in sickle cell disease is associated with increased reactivity of VWF, without a pronounced ADAMTS-13 deficiency

  13. The endogenous plasmin activation alone is not sufficient to cause Thrombotic thrombocytopenic purpura (TTP), but plasmin activation with ADAMTS13 deficiency might increase the risk of TTP onset.

  14. the N-linked glycans of ADAMTS-13 play a crucial role in regulating ADAMTS-13 activity

  15. Complex VWF-ADAMTS13-mediated mechanisms disturb haemostasis in inflammatory bowel disease.

  16. Missense variant in ADAMTS13 gene in a patient with NCIPH decreases secretion and activity of ADAMTS13 protein.

  17. Deficiency of the von Willebrand factor-cleaving protease ADAMTS13 is central to the pathophysiology of thrombotic thrombocytopenic purpura. Reviewed is the evidence emerged from epidemiological studies of an inverse relationship between the plasma levels of ADAMTS13 and the risk of acute coronary syndrome. [review]

  18. Data indicate that in cultured endothelial cells, one role of endogenous ADAMTS-13 is regulation of angiogenesis, mediated through VEGF and AKT signaling pathway.

  19. ADAMTS13 haplotype had an independent protective effect on CAD and genetic variation of vWF V1565L polymorphism modulates ADAMTS13 activity.

  20. The relative deficiency of plasma ADAMTS13 activity in subarachnoid haemorrhage patients may associate with worse outcome.

Mouse (Murine) ADAM Metallopeptidase with Thrombospondin Type 1 Motif, 13 (ADAMTS13) interaction partners

  1. ADAMTS13-vWF axis is partially involved in the pathophysiology of kidney ischemic reperfusion injury.

  2. Adamts13 deficiency in obese mice promotes hepatic microthrombosis.

  3. results suggest that ADAMTS13 controls key steps of ischemic vascular remodeling and that recombinant ADAMTS13 is a putative therapeutic avenue for promoting stroke recovery.

  4. ADAMTS13 retards progression of diabetic nephropathy, most likely by inhibiting VWF-dependent intrarenal thrombosis.

  5. administration of ADAMTS13 5 minutes after occlusion dose-dependently dissolved these t-PA-resistant thrombi resulting in fast restoration of MCA patency and consequently reduced cerebral infarct sizes

  6. Sleeping beauty transposon-mediated gene therapy achieved sustained expression of transgene ADAMTS13 and long-term prophylaxis against congenital thrombotic thrombocytopenic purpura in Adamts13(-/-) mice.

  7. Results also suggest that Toxoplasma gondii-mediated apoptosis might play a pivotal role and a different type of role in the mechanism of neurodegeneration and neuropathology in the process of toxoplasma encephalitis. Furthermore, expression of ADAMTS-13 might give an idea of the progress and is critical for diagnosis of this disease.

  8. Letter: deficiency of ADAMTS13 results in increased formation of venous thrombosis in mice.

  9. ADAMTS13 substrate specificity

  10. Data indicate that the p.D187H mutation impairs ADAMTS13 activity and secretion and may contribute to thrombotic thrombocytopenic purpura.

  11. Data show that metalloendopeptidase ADAMTS13 does not directly promote development of adipose tissue.

  12. findings provide further evidence on the pathophysiological role for the ADAMTS13/VWF axis in atherosclerosis

  13. Carboxyl terminus of ADAMTS13 directly inhibits platelet aggregation and ultra large von Willebrand factor string formation under flow in a free-thiol-dependent manner.

  14. Three novel mutations in a homozygous state were identified in these patients: c.1308G>C, c.428T>C (p.Ile143Thr) and c.1709A>G (p.Tyr570Cys)

  15. The results indicate that the microvascular process induced by ADAMTS13 deficiency triggers complement activation on platelets and the endothelium, which may contribute to formation of thrombotic microangiopathy.

  16. model of acute myocardial infarction in ADAMTS13 gene deleted (Adamts13 -/-) mice

  17. We hypothesize that ADAMTS13 protects brain from ischemia-reperfusion injury by regulating von Willebrand factor -dependent inflammation as well as microvascular plugging

  18. Cyclophilin B activity regulated secretion and activity of ADAMTS13.

  19. Adamts13(-/-) mice developed larger myocardial infarctions than wild-type control mice.

  20. ADAMTS13 and VWF are causally involved in myocardial ischemia/reperfusion injury.

ADAMTS13 profil antigène

Profil protéine

This gene encodes a member of the ADAMTS (a disintegrin and metalloproteinase with thrombospondin motif) protein family. Members of the family share several distinct protein modules, including a propeptide region, a metalloproteinase domain, a disintegrin-like domain, and a thrombospondin type 1 (TS) motif. Individual members of this family differ in the number of C-terminal TS motifs, and some have unique C-terminal domains. The enzyme encoded by this gene is the von Willebrand Factor (vWF)-cleaving protease, which is responsible for cleaving at the site of Tyr842-Met843 of the vWF molecule. A deficiency of this enzyme is associated with thrombotic thrombocytopenic purpura. Alternative splicing of this gene generates multiple transcript variants encoding different isoforms.

Gene names and symbols associated with ADAMTS13

  • ADAM metallopeptidase with thrombospondin type 1 motif 13 (ADAMTS13) anticorps
  • a disintegrin-like and metallopeptidase (reprolysin type) with thrombospondin type 1 motif, 13 (Adamts13) anticorps
  • ADAM metallopeptidase with thrombospondin type 1 motif, 13 (adamts13) anticorps
  • ADAM metallopeptidase with thrombospondin type 1 motif, 13 (Adamts13) anticorps
  • ADAM metallopeptidase with thrombospondin type 1 motif 13 (Adamts13) anticorps
  • ADAM-TS13 anticorps
  • ADAMTS-13 anticorps
  • ADAMTS13 anticorps
  • C9orf8 anticorps
  • Gm710 anticorps
  • vWF-CP anticorps
  • VWFCP anticorps

Protein level used designations for ADAMTS13

ADAM metallopeptidase with thrombospondin type 1 motif, 13 , A disintegrin and metalloproteinase with thrombospondin motifs 13 , a disintegrin-like and metalloprotease (reprolysin type) with thrombospondin type 1 motif, 13 , vWF-cleaving protease , von Willebrand factor-cleaving protease , ADAM-TS 13 , ADAM-TS13 , ADAMTS-13 , ADAMTS13 isoform IAP-b , vWF-CP mRNA for von Willebrand factor-cleaving , ADAM metallopeptidase with thrombospondin type 1 motif, 13 isoform 1 preproprotein-like , A disintegrin and metalloproteinase with thrombospondin motifs 13-like , a disintegrin-like and metallopeptidase (reprolysin type) with thrombospondin type 1 motif, 13

GENE ID SPECIES
100069281 Equus caballus
11093 Homo sapiens
279028 Mus musculus
532272 Bos taurus
100320289 Danio rerio
100404947 Callithrix jacchus
100343027 Oryctolagus cuniculus
100481099 Ailuropoda melanoleuca
100226372 Taeniopygia guttata
100630922 Canis lupus familiaris
102554393 Rattus norvegicus
100727045 Cavia porcellus
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