ATP Citrate Lyase (ACLY) Kits ELISA

ATP citrate lyase is the primary enzyme responsible for the synthesis of cytosolic acetyl-CoA in many tissues. De plus, nous expédions ACLY Anticorps (141) et ACLY Protéines (4) et beaucoup plus de produits pour cette protéine.

list all ELISA KIts Gène GeneID UniProt
ACLY 47 P53396
ACLY 104112 Q91V92
ACLY 24159 P16638
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Catalogue No. Reactivité Sensibilité Gamme Images Quantité Livraison Prix Détails
Humain 11.75 pg/mL 47-3000 pg/mL Typical standard curve 96 Tests 15 to 18 Days
  96 Tests 2 to 3 Days
  96 Tests 2 to 3 Days
  2 x 96 Tests 2 to 3 Days
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  96 Tests 15 to 18 Days

Plus Kits ELISA pour ACLY partenaires d'interaction

Human ATP Citrate Lyase (ACLY) interaction partners

  1. regulation of ACL activity is a potentially important point of control for cell cycle regulation in the myeloid lineage.

  2. Genetic variants that mimic the effect of ATP citrate lyase inhibitors and statins appeared to lower plasma LDL cholesterol levels by the same mechanism of action and were associated with similar effects on the risk of cardiovascular disease per unit decrease in the LDL cholesterol level.

  3. Increased ACLY activity in osteoarthritis chondrocytes increased nucleocytosolic acetyl-CoA, leading to increased matrix catabolism via dysregulated histone and transcription factor acetylation.

  4. SLC25A1 and ACLY upregulation suggests that metabolic reprogramming in Behcet's syndrome involves the citrate pathway dysregulation.

  5. ACL regulates the net amount of acetyl groups available, leading to alterations in acetylation of H3(K9/14) and H3(K27) at the MYOD locus, thus increasing MYOD expression.

  6. Results show that ACLY was up-regulated in human gastric cancer (GC) tissues and cell lines and a critical downstream target of the tumor suppressor activity of miR-133b in GC.

  7. ACLY and ACSS2 are both activated to produce cytosolic Ac-CoA from glucose carbon for lipogenesis during human cytomegalovirus infection.

  8. ACLY facilitates histone acetylation at double-strand break (DSB) sites, impairing 53BP1 localization and enabling BRCA1 recruitment and DNA repair by homologous recombination. ACLY phosphorylation and nuclear localization are necessary for its role in promoting BRCA1 recruitment.

  9. The protein crystallized consisted of residues 2-425-ENLYFQ and S-488-810 of human ATP-citrate lyase. (2S,3S)-2-Hydroxycitrate binds in the same orientation as citrate, but the citrate-binding domain (residues 248-421) adopts a different orientation with respect to the rest of the protein (residues 4-247, 490-746 and 748-809) from that previously seen.

  10. CUL3 interacts with ACLY through its adaptor protein, KLHL25 (Kelch-like family member 25), to ubiquitinate and degrade ACLY in cells

  11. we found that depletion of ATP citrate lyase suppressed tumor growth, which suggests that ATP citrate lyase-related inhibitors might be potential therapeutic approaches for breast cancer.

  12. Results show that ACLY is a key phosphoprotein effector of IL-2-mediated T-cell responses. ACLY becomes phosphorylated on serine 455 in T lymphocytes upon IL-2-driven activation of AKT, and depletion or inactivation of ACLY compromises IL-2-promoted T-cell growth.

  13. ACLY was also required for LMW-E-mediated transformation, migration, and invasion of breast cancer cells in vitro along with tumor growth in vivo In clinical specimens of breast cancer, the absence of LMW-E and low expression of adipophilin (PLIN2), a marker of lipid droplet formation, associated with favorable prognosis

  14. ACC1 and ACLY regulate the levels of ETV4 under hypoxia via increased alpha-ketoglutarate. These results reveal that the ACC1/ACLY-alpha-ketoglutarate-ETV4 axis is a novel means by which metabolic states regulate transcriptional output

  15. ACL activity is associated with increased ATP. Activation of this IGF1/ACL/cardiolipin pathway combines anabolic signaling with induction of mechanisms needed to provide required ATP.

  16. These results suggest that the combined expression of GLUT1 and ACLY could be a more valuable prognostic factor than their individual expression in node-negative patients with NSCLC.

  17. Polymorphisms of ATP citrate lyase gene is associated with recurrence in colorectal cancer.

  18. SNP rs9912300 in ACLY gene was significantly associated with response to therapy in hepatocellular carcinoma

  19. The activation of AMPK under ACLY knockdown conditions may lead to p53 activation, ultimately leading to cellular senescence.

  20. ATP citrate lyase mediates resistance of colorectal cancer cells to SN38.

Mouse (Murine) ATP Citrate Lyase (ACLY) interaction partners

  1. ACL regulates the net amount of acetyl groups available, leading to alterations in acetylation of H3(K9/14) and H3(K27) at the MYOD locus, thus increasing MYOD expression.

  2. We propose that D2-HG promotes cardiac dysfunction by impairing alpha-ketoglutarate dehydrogenase and induces histone modifications in an ACL-dependent manner

  3. these data indicate that engagement of acetate metabolism is a crucial, although partial, mechanism of compensation for ACLY deficiency.

  4. ACL plays a critical role in epigenetic regulation of diabetic renal fibrosis.

  5. ATP-citrate lyase inhibitor bempedoic acid effectively prevents plasma and tissue lipid elevations and attenuates the onset of inflammation, leading to the prevention of atherosclerotic lesion development in a Ldlr knockout mouse model of metabolic dysregulation.

  6. IL-4 signaling co-opts the Akt-mTORC1 pathway to regulate Acly, a key enzyme in acetyl-CoA synthesis, leading to increased histone acetylation and macrophage gene induction.

  7. These data demonstrate that ACLY mediates glucose-dependent de novo lipogenesis in response to LPS signaling and identify a role for ACLY in several phenotypic changes that define plasma cell differentiation

  8. Results suggest a role for DNA methyltransferase 1 (DNMT1) in modulating the timing of differentiation and describe a novel ATP-citrate lyase (ACL)-miR-148a-dependent mechanism for regulating DNMT1 during adipogenesis.

  9. Differences between human and rodent pancreatic islets: low pyruvate carboxylase, atp citrate lyase, and pyruvate carboxylation and high glucose-stimulated acetoacetate in human pancreatic islets.

  10. Results demonstrate that hepatic ATP-citrate lyase suppression exerts profound effects on triglyceride mobilization as well as fatty acid compositions in the liver, suggesting an important role for ACL in lipid metabolism.

  11. Data suggest that ATP-citrate lyase (ACLY) expression and activity can be suppressed by exogenous lipids and demonstrate a critical role for ACLY in pancreatic beta cell survival.

  12. crucial role of hepatic ATP-citrate lyase in lipid and glucose metabolism

  13. findings suggest that ATP-citrate lyase activity is required to link growth factor-induced increases in nutrient metabolism to the regulation of histone acetylation and gene expression

Pig (Porcine) ATP Citrate Lyase (ACLY) interaction partners

  1. The results of this study indicate that a C/T mutation affects ACL mRNA expression, probably via the activator protein 2.

Cow (Bovine) ATP Citrate Lyase (ACLY) interaction partners

  1. we identified three non-synonymous mutations in ACLY exons in five beef cattle populations. Single nucleotide polymorphism (SNP) g.17127C>T is significantly associated with chest girth and body height, and with body slanting length. SNP g.40427T>C is significantly associated with an increase in chest girth. ACLY gene are associated with growth traits in beef cattle in northwest China

ACLY profil antigène

Antigen Summary

ATP citrate lyase is the primary enzyme responsible for the synthesis of cytosolic acetyl-CoA in many tissues. The enzyme is a tetramer (relative molecular weight approximately 440,000) of apparently identical subunits. It catalyzes the formation of acetyl-CoA and oxaloacetate from citrate and CoA with a concomitant hydrolysis of ATP to ADP and phosphate. The product, acetyl-CoA, serves several important biosynthetic pathways, including lipogenesis and cholesterogenesis. In nervous tissue, ATP citrate-lyase may be involved in the biosynthesis of acetylcholine. Two transcript variants encoding distinct isoforms have been identified for this gene.

Gene names and symbols associated with ATP Citrate Lyase (ACLY) Kits ELISA

  • ATP citrate lyase (ACLY) anticorps
  • ATP citrate lyase S homeolog (acly.S) anticorps
  • ATP-citrate synthase (LOC587157) anticorps
  • ATP citrate lyase (acly) anticorps
  • ATP citrate lyase (ATPCL) anticorps
  • ATP-citrate synthase (LOC5564509) anticorps
  • citrate synthase, mitochondrial (CpipJ_CPIJ010291) anticorps
  • ATP-citrate synthase (Bm1_26245) anticorps
  • atp-citrate synthase (ACL) anticorps
  • ATP citrate lyase (Acly) anticorps
  • ATP citrate lyase a (aclya) anticorps
  • A730098H14Rik anticorps
  • ACL anticorps
  • acly anticorps
  • anon-WO0140519.179 anticorps
  • ATPCL anticorps
  • AW538652 anticorps
  • BcDNA:LD21334 anticorps
  • cb722 anticorps
  • CG8322 anticorps
  • Clatp anticorps
  • dATPCL anticorps
  • DDBDRAFT_0205389 anticorps
  • DDBDRAFT_0235360 anticorps
  • DDB_0205389 anticorps
  • DDB_0235360 anticorps
  • DmATPCL anticorps
  • Dmel\\CG8322 anticorps
  • l(2)01466 anticorps
  • l(2)k09217 anticorps
  • n(2)k09217 anticorps
  • zgc:92008 anticorps

Protein level used designations for ATP Citrate Lyase (ACLY) Kits ELISA

ATP citrate lyase , ATP citrate synthase , ATP-citrate synthase-like , ATP-citrate lyase , ATPCL-PD , ATPCL-PE , ATPCL-PF , CG8322-PD , CG8322-PE , CG8322-PF , ATP-citrate synthase , citrate synthase, mitochondrial , atp-citrate synthase , ATP-citrate (pro-S-)-lyase , citrate cleavage enzyme

100053195 Equus caballus
454672 Pan troglodytes
495086 Xenopus laevis
587157 Strongylocentrotus purpuratus
708501 Macaca mulatta
8621508 Dictyostelium discoideum AX4
100405725 Callithrix jacchus
100422779 Felis catus
100439535 Pongo abelii
100467494 Ailuropoda melanoleuca
36760 Drosophila melanogaster
5564509 Aedes aegypti
6042632 Culex quinquefasciatus
6100149 Brugia malayi
7201075 Phaeodactylum tricornutum CCAP 1055/1
47 Homo sapiens
104112 Mus musculus
24159 Rattus norvegicus
100125957 Sus scrofa
511135 Bos taurus
395373 Gallus gallus
607852 Canis lupus familiaris
654404 Ovis aries
436922 Danio rerio
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