ATP-Binding Cassette, Sub-Family A (ABC1), Member 7 (ABCA7) Kits ELISA

The protein encoded by ABCA7 is a member of the superfamily of ATP-binding cassette (ABC) transporters. De plus, nous expédions ABCA7 Anticorps (60) et ABCA7 Protéines (6) et beaucoup plus de produits pour cette protéine.

list all ELISA KIts Gène GeneID UniProt
ABCA7 27403 Q91V24
ABCA7 10347 Q8IZY2
ABCA7 299609 Q7TNJ2
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Top ABCA7 Kits ELISA sur

Showing 3 out of 12 products:

Catalogue No. Reactivité Sensibilité Gamme Images Quantité Livraison Prix Détails
Humain 0.045 ng/mL 0.156-10 ng/mL   96 Tests 2 to 3 Days
  96 Tests 2 to 3 Days
Rat < 0.071 ng/mL 0.156 ng/mL - 10 ng/mL   96 Tests 11 to 18 Days

Plus Kits ELISA pour ABCA7 partenaires d'interaction

Mouse (Murine) ATP-Binding Cassette, Sub-Family A (ABC1), Member 7 (ABCA7) interaction partners

  1. Study demonstrates that changes in surface CD1d expression and intracellular trafficking, as well as reduced CD1d localization to lipid rafts, are all caused by the absence of the ATP binding cassette transporter ABCA7.

  2. ABCA7 does not play a significant role in the regulation of cell proliferation or neurogenesis in the adult mouse.

  3. This study demonstrated that novel mechanism underlying how dysfunctions of ABCA7 contribute to the risk for alzheimer disease.

  4. ABCA7 has a role in Alzheimer amyloid processing

  5. Theresults of this study suggested that ABCA7 plays a role in the regulation of Abeta homeostasis in the brain and that this may be related to altered phagocyte function.

  6. Male knockout mice exhibited significantly impaired novel object recognition memory.Female knockout mice exhibited impaired spatial reference memory.

  7. ABCA7 may play a role in T cell proliferation and erythropoeisis in spleen

  8. concluded that statins enhance macrophage phagocytosis through the SREBP-ABCA7 pathway.

  9. Data suggest that extracellular helical apolipoproteins augment ABCA7-associated phagocytosis by stabilizing ABCA7, and show direct enhancement of the host defense system by HDL components.

  10. ABCA7 has the ability to bind apolipoproteins and promote efflux of cellular phospholipids without cholesterol, and has a possible role of ABCA7 in cellular phospholipid metabolism in peripheral tissues

  11. genetic knockdown of ABCA7 in mouse peritoneal macrophages did not affect phospholipid or cholesterol efflux to apoA-I

  12. ABCA7 plays a novel role in lipid and fat metabolism

  13. Mouse spermatozoa in the seminiferous tubules and epididymis express ABCA1, ABCA7 and ABCG1.

Human ATP-Binding Cassette, Sub-Family A (ABC1), Member 7 (ABCA7) interaction partners

  1. Study observed strong association between VNTR length and a genome-wide associated signal for Alzheimer's disease (AD) in the ABCA7 locus. Expanded VNTR alleles were highly enriched in AD patients. VNTR length inversely correlated with amyloid beta1-42 in cerebrospinal fluid and ABCA7 expression. Also identified three novel ABCA7 alternative splicing events.

  2. This study showed that ABCA7 genetic variants, especially the loss-of-function mutations, were significantly associated with the risk of Alzheimer's Disease.

  3. this meta-analysis suggested that ABCA7 rs3764650 polymorphism is significantly associated with Alzheimer's disease risk

  4. Study investigated the association between ABCA7 rs3764650 SNP and blood lipid levels in Southern Chinese Han sporadic Alzheimer's disease population, and found GG genotype was a risk factor of sporadic Alzheimer's disease as well as lipid homeostasis.

  5. The primary findings of this report are that abnormal ABCA7 exon 41 splicing is found in the brain of an individual carrying the minor C allele of rs200538373 and that rs200538373 is a functional SNP

  6. rs3764650 ABCA7 is not associated with late-onset Alzheimer's disease.

  7. Study uses targeted sequencing of ABCA7 to identify splicing, stop-gain and intronic risk variants for Alzheimer disease. Study shows that multiple variants in ABCA7 contribute to late-onset Alzheimer's disease risk.

  8. ABCA7 PTC mutations play a substantial role in early-onset Alzheimer disease, warranting genetic screening of ABCA7 in genetically unexplained patients.

  9. This study demonstrated that Genetic Variations in ABCA7 Can Increase Secreted Levels of Amyloid-beta40 and Amyloid-beta42 Peptides and ABCA7 Transcription in Cell Culture Models.

  10. Its genetic variation contributes to pathogenesis of Alzheimer disease.

  11. The major difference in the pattern of lipid peaks between ABCA7 and ABCA1 was the high lysoPC/PC ratio of ABCA7.

  12. It is a potential protective factor for Alzheimer's disease.(

  13. Results confirm that ABCA7 loss of function variants are enriched in patients with Alzheimer disease and extend this finding to predicted damaging missense variants

  14. A detailed clinicopathologic description of patients carrying an ABCA7 loss of function mutation: a classical Alzheimer disease phenotype, though with a striking wide onset age range, suggesting the influence of unknown modifying factors

  15. Results suggested that ABCA7 genotypes contribute to the AD risk through involvement in amyloid-beta deposition on in vivo imaging, but not in tau pathology, brain atrophy, or decreased glucose metabolism

  16. Common variants in ABCA7 and MS4A6A are associated with cortical and hippocampal atrophy.

  17. Studies indicate that ATP-binding cassette transporter A7 (ABCA7) single nucleotide polymorphisms (SNPs) that increase Alzheimer's disease (AD) risk.

  18. Study replicates the association of ABCA7 loss-of-function variants with Alzheimer's disease risk, and highlights the necessity of performing gene-based, rather than single-variant analyses to replicate the association in this type of studies

  19. ABCA7 has a role in Alzheimer amyloid processing

  20. The results are consistent with the view that assembly of HDL particles with extracellular apoA-I is primarily with the cellular phospholipid molecules being regulated in part by their physicochemical nature.

ABCA7 profil antigène

Antigen Summary

The protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the ABC1 subfamily. Members of the ABC1 subfamily comprise the only major ABC subfamily found exclusively in multicellular eukaryotes. This full transporter has been detected predominantly in myelo-lymphatic tissues with the highest expression in peripheral leukocytes, thymus, spleen, and bone marrow. The function of this protein is not yet known\; however, the expression pattern suggests a role in lipid homeostasis in cells of the immune system.

Gene names and symbols associated with ABCA7

  • ATP-binding cassette, sub-family A (ABC1), member 7 (Abca7) anticorps
  • ATP binding cassette subfamily A member 7 (ABCA7) anticorps
  • ATP binding cassette subfamily A member 7 (Abca7) anticorps
  • ATP-binding cassette sub-family A member 7 (LOC100088822) anticorps
  • Abc51 anticorps
  • ABCA-SSN anticorps
  • ABCA7 anticorps
  • ABCX anticorps

Protein level used designations for ABCA7

ATP-binding cassette sub-family A member 7 , autoantigen SS-N , macrophage ABC transporter , ATP-binding cassette, sub-family A (ABC1), member 7 , ATP-binding cassette, sub-family A, member 7

27403 Mus musculus
10347 Homo sapiens
299609 Rattus norvegicus
511762 Bos taurus
455538 Pan troglodytes
485090 Canis lupus familiaris
704976 Macaca mulatta
100088822 Ornithorhynchus anatinus
100623892 Sus scrofa
100726877 Cavia porcellus
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