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Probably catalytic subunit of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin- protein ligase complex that controls progression through mitosis and the G1 phase of the cell cycle.
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Human Polyclonal ANAPC11 Primary Antibody pour ELISA, IHC - ABIN4281020
Ohta, Michel, Xiong: Association with cullin partners protects ROC proteins from proteasome-dependent degradation. dans Oncogene 2000
Show all 2 Pubmed References
siRNA targeted against Apc11 could hamper entry into G2/M phase.
The authors showed, in vitro, a direct interaction between Orf virus anaphase promoting complex regulator and APC2 and its interference with interactions between APC11 and APC2.
Studies indicate that APC (Montrer APC Anticorps)/C(Cdh1 (Montrer CDH1 Anticorps)) is required to maintain genomic stability.
APC2 Cullin protein and APC11 RING protein comprise the minimal ubiquitin ligase module of the anaphase-promoting complex.
Inhibition of APC11 function by H(2)O(2) contributes to the delay in cell cycle progression through mitosis that is characteristic of cells subjected to oxidative stress
Probably catalytic subunit of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin- protein ligase complex that controls progression through mitosis and the G1 phase of the cell cycle. The APC/C is thought to confer substrate specificity and, in the presence of ubiquitin- conjugating E2 enzymes, it catalyzes the formation of protein- ubiquitin conjugates that are subsequently degraded by the 26S proteasome. In early mitosis, the APC/C is activated by CDC20 and targets securin PDS1, the B-type cyclin CLB5, and other anaphase inhibitory proteins for proteolysis, thereby triggering the separation of sister chromatids at the metaphase-to-anaphase transition. In late mitosis and in G1, degradation of CLB5 allows activation of the APC/C by CDH1, which is needed to destroy CDC20 and the B-type cyclin CLB2 to allow exit from mitosis and creating the low CDK state necessary for cytokinesis and for reforming prereplicative complexes in G1 prior to another round of replication. APC11 is required to recruit the ubiquitin- conjugating enzyme E2 to the APC/C.
APC11 anaphase promoting complex subunit 11 homolog
, anaphase promoting complex subunit 11 (yeast APC11 homolog)
, anaphase-promoting complex subunit 11
, cyclosome subunit 11
, hepatocellular carcinoma-associated RING finger protein
, anaphase promoting complex subunit 11
, anaphase promoting complex subunit 11 homolog
, Catalytic core subunit of the Anaphase-Promoting Complex/Cyclosome (APC/C), which is a ubiquitin-protein ligase required for degradation of anaphase inhibitors, including mitotic cyclins, during the metaphase/anaphase transition
, anaphase-promoting complex subunit Apc11
, potential anaphase-promoting complex subunit Apc11
, ubiquitin-protein ligase Anaphase Promoting Complex
, hypothetical protein
, anaphase-promoting complex/cyclosome 11