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The protein encoded by AMOTL1 is a peripheral membrane protein that is a component of tight junctions or TJs.
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Cow (Bovine) Polyclonal AMOTL1 Primary Antibody pour WB - ABIN2775636
Mehrle, Rosenfelder, Schupp, del Val, Arlt, Hahne, Bechtel, Simpson, Hofmann, Hide, Glatting, Huber, Pepperkok, Poustka, Wiemann: The LIFEdb database in 2006. dans Nucleic acids research 2005
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HECW2 (Montrer HECW2 Anticorps), a novel EC ubiquitin E3 ligase, plays a critical role in stabilizing endothelial cell-to-cell junctions by regulating AMOT (Montrer AMOT Anticorps)-like 1 (AMOTL1) stability.
AMOTL1 Promotes Breast Cancer Progression and Is Antagonized by Merlin (Montrer NF2 Anticorps).
phosphorylation-deficient S793Ala mutant of AMOTL1 showed a shorter half-life and conferred resistance to energy-stress-induced YAP (Montrer YAP1 Anticorps) inhibition.
study defined eight additional recurrently mutated genes in SMZL; these genes are CREBBP (Montrer CREBBP Anticorps), CBFA2T3 (Montrer CBFA2T3 Anticorps), AMOTL1, FAT4 (Montrer FAT4 Anticorps), FBXO11 (Montrer FBXO11 Anticorps), PLA2G4D (Montrer PLA2G4D Anticorps), TRRAP (Montrer TRRAP Anticorps) and USH2A (Montrer USH2A Anticorps).
miR (Montrer MLXIP Anticorps)-124 binds AmotL1 3'UTR (Montrer UTS2R Anticorps) and down-regulates its expression repressing vasculogenic mimicry and cell motility in cervical cancer cells.
Scaffold proteins angiomotin (Amot (Montrer AMOT Anticorps)) and angiomotin (Montrer AMOT Anticorps)-related AmotL1 and AmotL2 (Montrer AMOTL2 Anticorps) were recently identified as negative regulators of YAP (Montrer YAP1 Anticorps) and TAZ (Montrer TAZ Anticorps) by preventing their nuclear translocation.
These results suggested that IFN-gamma exhibits anti-angiogenesis effects by regulating the expression of TNF-alpha-induced AmotL1 via NFkappaB in emphysema lungs.
AmotL1 and ZO-2 (Montrer TJP2 Anticorps) are two candidates that could be harnessed to control the oncogenic function of YAP (Montrer YAP1 Anticorps).
By yeast two-hybrid screening, angiomotin-like 1 (AmotL1) was identified as a host factor that interacts with the M protein (Montrer MYOM2 Anticorps) of parainfluenza virus 5 (PIV5).
The angiomotin-like 1 is involved in actin-cytoskeleton-based processes, in part, via its interaction with a p80-angiomotin-containing complex and the actin cytoskeleton
Amot (Montrer AMOT Anticorps) and AmotL1 have similar effects on endothelial migration and tight junction formation in vitro. In vivo Amot (Montrer AMOT Anticorps) appears to control the cell polarity and AmotL1 affects the stability of cell-cell junctions.
The authors propose that AmotL1 is an essential effector of the N-cadherin (Montrer CDH2 Anticorps) mediated endothelial/pericyte junctional complex.
Amot (Montrer AMOT Anticorps), Amotl1, and Amotl2 (Montrer AMOTL2 Anticorps) are differentially expressed in uterine cells during the peri (Montrer POSTN Anticorps)-implantation period.
Data show that MUPP1 (Montrer MPDZ Anticorps) interacts with angiomotin (Amot (Montrer AMOT Anticorps)), JEAP/Amot (Montrer AMOT Anticorps)-like 1 and MASCOT/Amot (Montrer AMOT Anticorps)-like 2, and that all the Amot (Montrer AMOT Anticorps)/JEAP family proteins also interacted with Patj (Montrer INADL Anticorps), a close relative of MUPP1 (Montrer MPDZ Anticorps).
The protein encoded by this gene is a peripheral membrane protein that is a component of tight junctions or TJs. TJs form an apical junctional structure and act to control paracellular permeability and maintain cell polarity. This protein is related to angiomotin, an angiostatin binding protein that regulates endothelial cell migration and capillary formation.
angiomotin like 1
, angiomotin-like protein 1-like
, angiomotin-like protein 1
, junction-enriched and associated protein
, junction-enriched and -associated protein