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Bleomycin hydrolase (BMH) is a cytoplasmic cysteine peptidase that is highly conserved through evolution\; however, the only known activity of the enzyme is metabolic inactivation of the glycopeptide bleomycin (BLM), an essential component of combination chemotherapy regimens for cancer. De plus, nous expédions BLMH Protéines (20) et BLMH Kits (15) et beaucoup plus de produits pour cette protéine.
Showing 10 out of 89 products:
Human Polyclonal BLMH Primary Antibody pour ELISA, WB - ABIN560067
Englert, Kliment, Ramsgaard, Milutinovic, Crum, Tobolewski, Oury: Paradoxical function for the receptor for advanced glycation end products in mouse models of pulmonary fibrosis. dans International journal of clinical and experimental pathology 2011
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Human Polyclonal BLMH Primary Antibody pour WB - ABIN1881112
Ferrando, Velasco, Campo, Lopez-Otin: Cloning and expression analysis of human bleomycin hydrolase, a cysteine proteinase involved in chemotherapy resistance. dans Cancer research 1996
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Human Polyclonal BLMH Primary Antibody pour WB - ABIN1881113
Brömme, Rossi, Smeekens, Anderson, Payan: Human bleomycin hydrolase: molecular cloning, sequencing, functional expression, and enzymatic characterization. dans Biochemistry 1996
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Blmh interacts with diverse cellular processes--lipoprotein, amino acid and protein, carbohydrate, and energy metabolisms, detoxification, antioxidant defenses--that are essential for normal kidney homeostasis.
Bleomycin hydrolase protects against neurodegeneration associated with elevated homocysteine thiolactone levels in hyperhomocysteinemia and Alzheimer's disease.
bleomycin hydrolase functions as an MHC class I epitope-processing protease
BH does not play a major role either in generating or destroying class I major histocompatibility antigen (MHC)-presented peptides that bind to the MHC in living cells. These results point to redundant functions between peptidases.
the BLMH gene single nucleotide polymorphism A1450G (rs1050565) influences BLMH activity and late pulmonary toxicity.
Ubc9 (Montrer UBE2I Anticorps) plays different roles of action in antitumor agents in chemotherapy. The process requires bleomycin hydrolase and poly(ADP-ribose) polymerase-1 (Montrer PARP1 Anticorps). The results are beneficial to deeply understanding of Ubc9 (Montrer UBE2I Anticorps) functions and for precise prediction of chemotherapy outcomes in tumors.
Bleomycin hydrolase downregulation in lesional skin of adult atopic dermatitis patients is independent of filaggrin (Montrer FLG Anticorps) gene mutations
This study findings suggest that Blmh interacts with diverse cellular processes from energy metabolism and anti-oxidative defenses to cell cycle, cytoskeleton dynamics, and synaptic plasticity essential for normal brain homeostasis.
We also detected significant association between XRCC1 (Montrer XRCC1 Anticorps), XRCC3 (Montrer XRCC3 Anticorps), and BLHX polymorphisms and a high frequency of chromosomal damage
The caspase (Montrer CASP3 Anticorps)-dependent cleavage of BLH was confirmed by cleavage of partly-purified human bleomycin hydrolase with caspase-3 (Montrer CASP3 Anticorps).
present study suggests that our new method can detect novel genes of interest and that BLMH is a suppressor gene in HCC (Montrer FAM126A Anticorps)
This first report on BLMH carrier status in Tunisia shows o association between carrying the BLMH-G genotype and Alzheimer's disease in epsilon4 negative or positive subjects.
Cysteine proteases bleomycin hydrolase and cathepsin Z (Montrer CTSZ Anticorps) mediate N-terminal proteolysis and toxicity of mutant huntingtin (Montrer HTT Anticorps).
BH activity and expression were markedly decreased in AD lesional skin, suggesting a defect of the filaggrin (Montrer FLG Anticorps) degradation pathway in AD.
Bleomycin hydrolase (BMH) is a cytoplasmic cysteine peptidase that is highly conserved through evolution\; however, the only known activity of the enzyme is metabolic inactivation of the glycopeptide bleomycin (BLM), an essential component of combination chemotherapy regimens for cancer. The protein contains the signature active site residues of the cysteine protease papain superfamily.
, bleomycin hydrolase
, BLM hydrolase
, aminopeptidase H