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CTCF is a member of the BORIS + CTCF gene family and encodes a transcriptional regulator protein with 11 highly conserved zinc finger (ZF) domains.
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Human Monoclonal CTCF Primary Antibody pour ELISA, WB - ABIN969071
Grbesa, Marinkovic, Ivkic, Kruslin, Novak-Kujundzic, Pegan, Bogdanovic, Bedekovic, Gall-Troselj: Loss of imprinting of IGF2 and H19, loss of heterozygosity of IGF2R and CTCF, and Helicobacter pylori infection in laryngeal squamous cell carcinoma. dans Journal of molecular medicine (Berlin, Germany) 2008
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Human Polyclonal CTCF Primary Antibody pour IP - ABIN153008
Lai, Fatemi, Dhasarathy, Malone, Sobol, Geigerman, Jaye, Mav, Shah, Li, Wade: DNA methylation prevents CTCF-mediated silencing of the oncogene BCL6 in B cell lymphomas. dans The Journal of experimental medicine 2010
Human Monoclonal CTCF Primary Antibody pour ELISA, WB - ABIN965942
Majumder, Gomez, Chadwick, Boss: The insulator factor CTCF controls MHC class II gene expression and is required for the formation of long-distance chromatin interactions. dans The Journal of experimental medicine 2008
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Human Polyclonal CTCF Primary Antibody pour ChIP, ICC - ABIN4300770
Martínez, Cruz, Lu, Plasschaert, Deng, Rivera-Molina, Bartolomei, Lieberman, Tang: CTCF binding to the first intron of the major immediate early (MIE) gene of human cytomegalovirus (HCMV) negatively regulates MIE gene expression and HCMV replication. dans Journal of virology 2014
Human Polyclonal CTCF Primary Antibody pour ChIPSeq, ChIP - ABIN2668282
Moriguchi, Yu, Takai, Hayashi, Satoh, Suzuki, Ohneda, Yamamoto: The Human GATA1 Gene Retains a 5' Insulator That Maintains Chromosomal Architecture and GATA1 Expression Levels in Splenic Erythroblasts. dans Molecular and cellular biology 2015
We propose that cohesin and CTCF have distinct functions in the regulation of runx1 (Montrer RUNX1 Anticorps) during zebrafish embryogenesis.
Data conclude that CTCF modulates MRF (Montrer C11orf9 Anticorps) functional interactions in the orchestration of myogenesis.
CCCTC-binding factor CTCF supports the homeostatic maintenance of hematopoietic stem cell (HSCs) pools by sustaining HSC (Montrer FUT1 Anticorps) quiescence in a reactive oxygen species ROS (Montrer ROS1 Anticorps)-dependent manner.
Authors show that mice devoid of an inducible CTCF binding element, located in the alpha constant gene, display a marked isotype-specific increase of GL transcription in developing and resting splenic B cells and altered CSR (Montrer SCARA3 Anticorps) in activated B cells.
The study provides evidence that CTCF regulates chromatin organization during spermiogenesis, contributing to the functional organization of mature sperm.
CTCF Binding Sites in the Herpes Simplex Virus 1 Genome Display Site-Specific CTCF Occupation, Protein Recruitment, and Insulator Function.
Both LDB1 (Montrer LDB1 Anticorps) and CTCF are required for enhancer-Car2 (Montrer CA2 Anticorps) looping, and the domain of LDB1 (Montrer LDB1 Anticorps) contacted by CTCF is necessary to rescue Car2 (Montrer CA2 Anticorps) transcription in LDB1 (Montrer LDB1 Anticorps)-deficient cells.
CTCF physically associates with Wdr5 (Montrer WDR5 Anticorps) and further transcriptionally controls its expression by directly targeting the Wdr5 (Montrer WDR5 Anticorps) gene promoter.
Since CTCF and cohesin are required for loop domain formation, our results suggest that chromatin loops are dynamic and frequently break and reform throughout the cell cycle.
Nearly half of all DNase (Montrer DNASE2 Anticorps) hypersensitivity sites (both constitutive and dynamic) overlap binding events of the bone-essential RUNX2 (Montrer RUNX2 Anticorps) and/or the chromatin-related CTCF transcription factors.
Chromatin immunoprecipitation-DNA sequence analysis was performed in adult cerebellum and Wiz (Montrer ZNF803 Anticorps) peaks were found at promoters and transcription factor CTCF binding sites.
CTCF knockdown attenuates fear-conditioning-induced hippocampal gene expression of key learning genes and loss of long-range interactions at the BDNF (Montrer BDNF Anticorps) and Arc (Montrer NOL3 Anticorps) loci.
This study confirms that haploinsufficiency of CTCF causes distinct clinical features, and that a microdeletion encompassing CTCF could cause a recognisable CTCF deletion syndrome. Perturbed DNA methylation (Montrer HELLS Anticorps) at CTCF binding sites, not at imprinted loci, may underlie the pathomechanism of the syndrome.
structural studies show that the sequence-specific interactions between zinc fingers and CTCF-binding sites determine the directionality and conservation of CTCF recognition.
CTCF may be a key factor that contributes to gene co-mutations in cancer.
results support a model in which YY1 (Montrer YY1 Anticorps) acts as an architectural protein to connect developmentally regulated looping interactions; the location of YY1 (Montrer YY1 Anticorps)-mediated interactions may be demarcated in development by a preexisting topological framework created by constitutive CTCF-mediated interactions.
The MeCP2, a protein whose mutated forms are involved in Rett syndrome; and CTCF, a constitutive transcriptional insulator.
The results show that cohesin has an essential genome-wide function in mediating long-range chromatin interactions and support the hypothesis that cohesin creates these by loop extrusion, until it is delayed by CTCF in a manner dependent on PDS5 proteins, or until it is released from DNA by WAPL (Montrer WAPAL Anticorps).
CTCF-FOXM1 (Montrer FOXM1 Anticorps) axis regulates tumour growth and metastasis in hepatocellular carcinoma cells.
we show CTCF binding site mutations to be functional by demonstrating allele-specific reduction of CTCF binding to mutant alleles. While topologically associating domains with mutated CTCF anchors in melanoma contain differentially expressed cancer-associated genes, CTCF motif mutations appear generally under neutral selection
CTCF-mediated long-range interactions are integral for a multitude of topological features of interphase chromatin, such as the formation of topologically associated domains, domain insulation, enhancer blocking and even enhancer function.
Authors have identified two novel pro-tumorigenic roles (promoting cell survival and altering cell polarity) for genetic alterations of CTCF in endometrial cancer.
This gene is a member of the BORIS + CTCF gene family and encodes a transcriptional regulator protein with 11 highly conserved zinc finger (ZF) domains. This nuclear protein is able to use different combinations of the ZF domains to bind different DNA target sequences and proteins. Depending upon the context of the site, the protein can bind a histone acetyltransferase (HAT)-containing complex and function as a transcriptional activator or bind a histone deacetylase (HDAC)-containing complex and function as a transcriptional repressor. If the protein is bound to a transcriptional insulator element, it can block communication between enhancers and upstream promoters, thereby regulating imprinted expression. Mutations in this gene have been associated with invasive breast cancers, prostate cancers, and Wilms' tumors. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.
transcriptional repressor CTCF
, CCCTC-binding factor (zinc finger protein)
, transcriptional repressor CTCF-like
, 11-zinc finger protein
, CTCFL paralog
, 11 zinc finger transcriptional repressor