CD47 Protéines (CD47)

CD47 encodes a membrane protein, which is involved in the increase in intracellular calcium concentration that occurs upon cell adhesion to extracellular matrix. De plus, nous expédions CD47 Anticorps (294) et CD47 Kits (17) et beaucoup plus de produits pour cette protéine.

afficher tous les protéines Gène GeneID UniProt
CD47 16423 Q61735
CD47 961 Q08722
CD47 29364 P97829
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Top CD47 Protéines sur anticorps-enligne.fr

Showing 10 out of 61 products:

Catalogue No. Origin Source Conjugué Images Quantité Livraison Prix Détails
HEK-293 Cells Humain His tag 10 μg 2 to 3 Days
$200.00
Détails
HEK-293 Cells Humain Fc Tag Human CD47, Fc Tag (HPLC-verified) on SDS-PAGE under reducing (R) condition. The gel was stained overnight with Coomassie Blue. The purity of the protein is greater than 95%. Immobilized Human CD47, Fc Tag (HPLC-verified)  with a linear range of 16-250 ng/mL. 100 μg 5 Days
$319.00
Détails
Cellules d'insectes Humain rho-1D4 tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 0.5 mg 50 to 55 Days
$7,493.38
Détails
Cellules d'insectes Souris rho-1D4 tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 0.25 mg 50 to 55 Days
$5,262.31
Détails
Escherichia coli (E. coli) Souris His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg 30 to 35 Days
$5,370.21
Détails
HEK-293 Cells Humain AVI tag,Biotin,His tag Biotinylated Human CD47, His Tag on SDS-PAGE under reducing (R) condition. The gel was stained overnight with Coomassie Blue. The purity of the protein is greater than 95%. Immobilized Anti-CD47 MAb, Human IgG4 at 2μg/mL (100 μL/well) can bind Biotinylated Human CD47, His Tag  with a linear range of 0.07-0.84 ng/mL. 200 μg 5 Days
$1,518.00
Détails
Human Cells Humain Fc Tag 100 μg 14 to 16 Days
$440.65
Détails
Escherichia coli (E. coli) Souris His tag 100 μg 15 to 18 Days
$560.00
Détails
Human Cells Humain His tag   50 μg 4 Days
$280.50
Détails
Human Cells Rat His tag 100 μg 14 to 16 Days
$440.65
Détails

CD47 Protéines protéines par origine et source

Origin Exprimée danse Conjugué
Mouse (Murine) , , , ,
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Human , , , , , , ,
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Rat (Rattus) ,
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CD47 Protéines mieux référencés

  1. Human CD47 Protein expressed in HEK-293 Cells - ABIN2180805 : Piccio, Vermi, Boles, Fuchs, Strader, Facchetti, Cella, Colonna: Adhesion of human T cells to antigen-presenting cells through SIRPbeta2-CD47 interaction costimulates T-cell proliferation. dans Blood 2005 (PubMed)
    Show all 4 Pubmed References

  2. Human CD47 Protein expressed in HEK-293 Cells - ABIN2180804 : Lindberg, Gresham, Schwarz, Brown: Molecular cloning of integrin-associated protein: an immunoglobulin family member with multiple membrane-spanning domains implicated in alpha v beta 3-dependent ligand binding. dans The Journal of cell biology 1993 (PubMed)
    Show all 4 Pubmed References

  3. Human CD47 Protein expressed in HEK-293 Cells - ABIN2870532 : Weiskopf: Cancer immunotherapy targeting the CD47/SIRPα axis. dans European journal of cancer (Oxford, England : 1990) 2017 (PubMed)

Plus protéines pour CD47 partenaires d'interaction

Mouse (Murine) CD47 interaction partners

  1. these results demonstrate that CD47-SIRPalpha signaling prevents excess microglial phagocytosis and show that molecular brakes can be regulated by activity to protect specific inputs

  2. this study shows that miR-378a modulates macrophage phagocytosis and differentiation through targeting CD47-SIRPalpha axis in atherosclerosis

  3. Herein, we reported a novel dual-targeting therapy for glioblastoma through simultaneous blockade of VEGF and CD47 signaling.

  4. Microglia are effector cells of CD47-SIRPalpha antiphagocytic axis disruption against glioblastoma.

  5. These results establish that CD36 and CD47 both participate in mediating the actions of TSP-1 in osteoclasts and establish a physiologically relevant cross-talk in bone tissue between these two molecules.

  6. CD11c and its partner Itgb2 were required for DC capture of CD47-deficient cells. CD11b was not necessary for this process but could partially compensate in the absence of CD11c. Mice with DCs lacking Talin1, Itgb2, or CD11c were defective in supporting T-cell proliferation and differentiation induced by CD47-deficient cell associated antigen.

  7. this study shows that inhibition of IAP represses inflammatory status via nuclear factor-kappa B pathway in murine endometriosis lesions

  8. Our results support an intrinsic role of CD47 in ovarian cancer progression and immune evasion

  9. Mechanistic studies suggest a PKC-Syk-mediated signaling pathway, to which IL-10 conversely inhibits, is required for activating macrophage self-targeting, followed by phagocytosis independent of calreticulin Moreover, we identified spleen red pulp to be one specific tissue that provides stimuli constantly activating macrophage phagocytosis albeit lacking in Cd47(-/-) or Sirpalpha(-/-) mice.

  10. mice deficient in CD47 (CD47 Knockout) had significantly less brain neutrophil infiltration at 24h, upregulated VEGF expression in peri-lesion cortex at 7 and 14day

  11. TSP1 significantly accelerates replicative senescence and associated cell cycle arrest in a CD47-dependent manner.

  12. CD47, TSP1, and to a lesser extent SIRPalpha facilitate exosome-mediated myeloid-derived suppressor cells chemotaxis and migration.

  13. In pulmonary hypertension TSP1-CD47 is upregulated, and contributes to pulmonary arterial vasculopathy and dysfunction.

  14. thrombospondin-1 via CD47 inhibits renal tubular epithelial cell recovery after ischemia reperfusion injury through inhibition of proliferation/self-renewal.

  15. these findings have demonstrated how tumor cells inhibit innate sensing in dendritic cells and suggested that the CD47-SIRPalpha axis is critical for dendritic cell-driven antitumor immunity

  16. this study shows that CD47 deficiency in tumor stroma promotes tumor progression by enhancing angiogenesis

  17. the results obtained by combining bioinformatics and preclinical studies strongly suggest that targeting TSP-1/CD47 axis may represent a valuable therapeutic alternative for hampering melanoma spreading.

  18. These results identify CD47 as an important regulator of LFA-1 and VLA-4 integrin-adhesive functions in T cell proliferation.

  19. Treg cells protect dopaminergic neurons against MPP+ neurotoxicity by a cell-to-cell contact mechanism underlying CD47-SIRPA interaction and Rac1/Akt activation.

  20. CD47 deficient mice with vaccination showed greater protective efficacy against lethal challenge.

Human CD47 interaction partners

  1. CD47 and PD-L1 serve as critical innate and adaptive checkpoints, respectively, both of them are critical to the immune system. Therefore, we believe this dual-targeting strategy will provide insight into tumor immunotherapy for better tumor control.

  2. QPCTL is critical for pyroglutamate formation on CD47 at the SIRPalpha binding site shortly after biosynthesis.

  3. These results suggest that CD47 might be a useful predictor of poor prognosis and metastasis and a potential target for treating glioblastomas.

  4. CD47 blockade enhances therapeutic activity of TCR mimic antibodies to ultra-low density cancer epitopes.

  5. cancer cell expression of SLAMF7 is not required for phagocytosis and, in contrast to CD47 expression, should not be used as selection criterion for CD47-targeted therapy.

  6. PD1/PDL1 and CD47 may be involved in the disease progression and prognosis of T-lymphoblastic lymphoma/leukemia

  7. this study shows that CD47 blockade inhibits tumor progression through promoting phagocytosis of tumor Cells by M2 polarized macrophages in endometrial cancer

  8. Therefore, the differential responses observed with CD47 blockade are due to autonomous activation of protective autophagy in normal tissue and enhancement immune cytotoxicity against cancer cells.

  9. results suggest that cancers can evolve SE to drive CD47 overexpression to escape immune surveillance

  10. overexpression of human CD200 in donor pigs could constitute a promising strategy for overcoming xenograft rejection.

  11. High CD47 expression is associated with the increase in the ability of surviving breast cancer cells to evade innate and adaptive immunity.

  12. CD47 expression is decreased on the surface of erythrocytes in obese subjects. These changes in CD47 expression on the erythrocytes surface may be an adaptive response to hyperfibrinogenemia associated with obesity.

  13. Results show that the thrombospondin 1 (TSP1) and its receptor CD47 (CD47) axis selectively regulates NADPH oxidase 1 (Nox1) in the regulation of endothelial senescence and suggest potential targets for controlling the aging process at the molecular level.

  14. CD47 is overexpressed in primary non-small cell lung cancer (NSCLC) tissues and cell lines, suggesting that CD47 is a promising therapeutic target for NSCLC.

  15. Among the various candidate genes involved in acute rejection, CD47 inhibits monocyte/macrophage-mediated phagocytosis by identifying the CD47 signal regulatory protein alpha (SIRP-alpha) as self/non-self. Tissue factor pathway inhibitor (TFPI) is involved in the regulation of the coagulation pathway and is able to bind to another ligand of CD47, thrombospondin-1 (TSP-1).

  16. Blocking CD47 using antibodies could efficiently induce macrophage-mediated phagocytosis of tumor cells and treat cancers.

  17. High CD47 expression is not associated with Fibrolamellar Hepatocellular Carcinoma.

  18. TTI-621 (SIRPalphaFc) is a fully human recombinant fusion protein that blocks the CD47-SIRPalpha axis by binding to human CD47 and enhancing phagocytosis of malignant cells..These data indicate that TTI-621 is active across a broad range of human tumors.

  19. this review highlights the various functions of CD47, discusses anti-tumor responses generated by both the innate and adaptive immune systems as a consequence of administering anti-CD47 blocking antibody, and finally elaborates on the clinical potential of CD47 blockade.

  20. we observed neutrophilic infiltration was slightly increased in anti-CD47 treated tumors compared to IgG control.

Pig (Porcine) CD47 interaction partners

  1. Amyloid-beta inhibits No-cGMP signaling in a CD36- and CD47-dependent manner

  2. Genetic induction of human CD47 on porcine cells could provide inhibitory signaling to SIRPalpha on human macrophages, providing a novel approach to preventing macrophage-mediated xenograft rejection.

Cow (Bovine) CD47 interaction partners

  1. temporal expression and localization pattern of the thrombospondins and their specific receptors in the antral follicles and corpora lutea during the different physiological phases of the estrous cycle and induced luteolysis appear to be compatible with their inhibitory role in the control of ovarian angiogenesis

Profil protéine CD47

Profil protéine

This gene encodes a membrane protein, which is involved in the increase in intracellular calcium concentration that occurs upon cell adhesion to extracellular matrix. The encoded protein is also a receptor for the C-terminal cell binding domain of thrombospondin, and it may play a role in membrane transport and signal transduction. This gene has broad tissue distribution, and is reduced in expression on Rh erythrocytes. Alternatively spliced transcript variants have been found for this gene.

Gene names and symbols associated with CD47 Protéines (CD47)

  • CD47 antigen (Rh-related antigen, integrin-associated signal transducer) (Cd47)
  • CD47 molecule (CD47)
  • Cd47 molecule (Cd47)
  • 9130415E20Rik Protéine
  • AA407862 Protéine
  • AI848868 Protéine
  • AW108519 Protéine
  • B430305P08Rik Protéine
  • CD47/IAP Protéine
  • IAP Protéine
  • Itgp Protéine
  • MER6 Protéine
  • OA3 Protéine

Protein level used designations for CD47 Protéines (CD47)

Rh-related antigen , integrin-associated protein , leukocyte surface antigen CD47 , CD47 antigen (Rh-related antigen, integrin-associated signal transducer) , CD47 glycoprotein , antigen identified by monoclonal antibody 1D8 , antigenic surface determinant protein OA3 , integrin associated protein , integrin-associated signal transducer , CD47 antigen , IAP

GENE ID SPECIES
16423 Mus musculus
961 Homo sapiens
478552 Canis lupus familiaris
397042 Sus scrofa
282661 Bos taurus
101111153 Ovis aries
29364 Rattus norvegicus
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