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CARD6 encodes a protein that contains a caspase recruitment domain (CARD), an antiparallel six-helical bundle that mediates homotypic protein-protein interactions.
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these data indicated that CARD6 serves as a novel cardioprotective factor via negative regulation of MEK kinase-1 (Montrer MAP3K1 Kits ELISA)-dependent MEK (Montrer MDK Kits ELISA)-ERK1/2 (Montrer MAPK1/3 Kits ELISA) and JNK1 (Montrer MAPK8 Kits ELISA)/2 signaling
CARD6 is a regulator of NF-kappaB (Montrer NFKB1 Kits ELISA) activation that modulates the functions of RICK protein
Data show that NOD-like receptor signaling genes NOD2 (Montrer NOD2 Kits ELISA), PYCARD (Montrer PYCARD Kits ELISA), CARD6, and IFI16 (Montrer IFI16 Kits ELISA) are upregulated in psoriatic epidermis.
The increased expression of CARD6 in esophageal squamous cell carcinoma,gastric and colorectal adenocarcinoma suggested that neoexpression of CARD6 might be related to activation of NF-kappaB (Montrer NFKB1 Kits ELISA) pathway.
identification as a modulator of NF-kappa B (Montrer NFKB1 Kits ELISA) activation by Nod1 (Montrer NOD1 Kits ELISA)- and Cardiak-mediated pathways
review of the regulation of interactions of CARD6 with RICK and microtubules [review]
This gene encodes a protein that contains a caspase recruitment domain (CARD), an antiparallel six-helical bundle that mediates homotypic protein-protein interactions. The encoded protein is a microtubule-associated protein that has been shown to interact with receptor-interacting protein kinases and positively modulate signal transduction pathways converging on activation of the inducible transcription factor NF-kB.
caspase recruitment domain family, member 6
, caspase recruitment domain-containing protein 6
, caspase recruitment domain-containing protein 6-like
, CARD-containing inhibitor of Nod1 and Cardiak-induced NF-kB activation
, caspase recruitment domain protein 6