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CHRDL1 encodes an antagonist of bone morphogenetic protein 4.
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Finally, in vivo experiments confirmed that CHRDL1 acted as a tumor suppressor gene in suppressing tumor growth and metastasis
Results show that Chrdl1 expression is upregulated in numerous breast cancer cells following TGF-beta (Montrer TGFB1 Anticorps) stimulation and demonstrated that Chrdl1 acts as an inhibitor of BMP4 (Montrer BMP4 Anticorps)-induced migration and invasion.
These studies have identified and validated new factors enriched in juvenile chondrocytes as compared to adult chondrocytes including secreted extracellular matrix factors chordin-like 1 (CHRDL1) and microfibrillar-associated protein 4 (MFAP4 (Montrer MFAP4 Anticorps)).
We provide the initial confirmation that X-linked megalocornea is associated with mutations in the CHRDL1 gene.
CHRDL1 plays a key role in cornea homeostasis as evidenced by disease causing mutations in X-linked megalocornea.
The detection of mutations in the CHRDL1 gene is useful for differential diagnosis with different forms of megalocornea.
Novel CHRDL1 mutations in ten families with X-linked megalocornea, are reported.
CHRDL1 is expressed in the developing human cornea and anterior segment in addition to the retina.
Hypoxia-induced upregulation of CHL-1 (Montrer DDX11 Anticorps) alters the homeostatic balance between BMP-4 (Montrer BMP4 Anticorps) and VEGF (Montrer VEGFA Anticorps) to synergize with VEGF (Montrer VEGFA Anticorps) in driving retinal angiogenesis.
reports the cloning of chick ventroptin and its importance in topographic retinotectal projection
CHRDL-1 is a new regulatory target of miR (Montrer MLXIP Anticorps)-134 during cortical neuronal differentiation; this is a novel role for miR (Montrer MLXIP Anticorps)-134 in the modulation of cortical development.
Reperfusion injury of proximal kidney tubules causes a reduction of Chrdl1 expression.
This gene encodes an antagonist of bone morphogenetic protein 4. The encoded protein may play a role in topographic retinotectal projection and in the regulation of retinal angiogenesis in response to hypoxia. Alternatively spliced transcript variants encoding different isoforms have been described.
chordin-like protein 1
, neuralin 1
, likely ortholog of mouse neuralin 1
, chordin-like 1
, chordin-like protein 1-like
, neurogenesin 1